Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Global Study Discovers Flurry of New Alzheimer’s Genes

Published: Wednesday, October 30, 2013
Last Updated: Wednesday, October 30, 2013
Bookmark and Share
An international study has uncovered 11 new genes that increase the chance of developing Alzheimer’s disease and provide new clues to ways of fighting it.

The study, which examined close to 75,000 people in 15 countries, doubles the number of known genes that increase Alzheimer’s risk in the elderly. “The international group identified as many new genes in this one study as have been found over the last 15 years combined,” says one of the study’s senior authors, Richard Mayeux, MD, chair of neurology at Columbia University Medical Center.

The study, which is being published in the Nov. issue of Nature Genetics, was conducted by dozens of researchers through the International Genomics of Alzheimer’s Project (IGAP), created in 2011.

None of the 11 new genes has as strong an  effect on Alzheimer’s as the APOE4 gene, which was linked to the disease in the 1990s. APOE4 accounts for about 20 percent of cases, while the strongest of the new genes accounts for, at most, 8 percent of cases.

The significance of the discovery lies instead in the number of possible new drug targets revealed by the study, including some that are involved in processes never before considered in Alzheimer’s.

“Six of our new genes suggest the existence of new pathways underlying Alzheimer’s,” Mayeux says. These areas include the junction between neurons in the hippocampus, the area of the brain where Alzheimer’s begins, and the activity of other cells in the brain surrounding the neurons.

Other new genes uncovered by the group are related to processes in the brain that are well-known contributors to Alzheimer’s, including the processes that lead to the build-up of toxic amyloid beta and tau deposits, or help confirm newer ideas such as inflammation. The identification of new genes involved in these processes may ultimately lead to new drugs.

What’s most needed now, the investigators say, is an intense effort to understand the precise roles of all 22 genes in the development of Alzheimer’s disease.

“At the end of the day, we want to find a way to halt or prevent the disease,” Mayeux says.  “The prospects of doing this are now somewhat greater, but we still have a lot of work to do.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Celiac Disease Risk Linked to Non-coding RNA
Suggests factors outside of protein-coding genes play a role in celiac disease.
Friday, April 01, 2016
Core Symptom of Schizophrenia Eliminated
Team uses chemical compound to restore affected brain regions; findings could lead to new treatment strategies.
Friday, February 19, 2016
Useful Colon Cancer Biomarker Discovered
Biomarker is detectable with simple, inexpensive test.
Monday, January 25, 2016
Link Between Congenital Heart, Brain Disorders
Tools of precision medicine may lead to earlier identification and treatment of children with neurodevelopmental disorders.
Thursday, December 10, 2015
DNA Abnormalities Found in Children with Chronic Kidney Disease
Routine genetic screening of children with CKD could lead to earlier, more precise diagnoses.
Tuesday, April 21, 2015
Patient-Specific Stem Cells and Personalized Gene Therapy
Patients’ own cells transformed into model for studying disease and developing potential treatment.
Saturday, July 12, 2014
Test Could Identify Which Prostate Cancers Require Treatment
3-gene biomarker gauges tumor’s aggressiveness.
Thursday, September 12, 2013
Scientific News
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Controlling RNA in Living Cells
Modular, programmable proteins can be used to track or manipulate gene expression.
Genetic Approach May Lead to New Treatments for Digestive Diseases
Researchers at UMass Medical School have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the digestive system.
Fructose Alters Hundreds of Brain Genes
UCLA scientists report that diet rich in omega-3 fatty acids can reverse the damage.
DNA Barcodes Gone Wild
A team of researchers at University of Toronto’s Donnelly Centre and Sinai Health System’s Lunenfeld-Tanenbaum Research Institute (LTRI) has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions.
New Genetic Risk Factors for Myopia Discovered
Genes and environment determine short-sightedness.
Targeting an ‘Undruggable’ Cancer Gene
RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers.
Biomarkers for Profiling Prostate Cancer Patients
Exiqon A/S has announced the publication of validation of prognostic microRNA biomarkers for the aggressiveness of prostate cancer in independent cohorts.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!