Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
Become a Member | Sign in
Home>News>This Article

Global Study Discovers Flurry of New Alzheimer’s Genes

Published: Wednesday, October 30, 2013
Last Updated: Wednesday, October 30, 2013
Bookmark and Share
An international study has uncovered 11 new genes that increase the chance of developing Alzheimer’s disease and provide new clues to ways of fighting it.

The study, which examined close to 75,000 people in 15 countries, doubles the number of known genes that increase Alzheimer’s risk in the elderly. “The international group identified as many new genes in this one study as have been found over the last 15 years combined,” says one of the study’s senior authors, Richard Mayeux, MD, chair of neurology at Columbia University Medical Center.

The study, which is being published in the Nov. issue of Nature Genetics, was conducted by dozens of researchers through the International Genomics of Alzheimer’s Project (IGAP), created in 2011.

None of the 11 new genes has as strong an  effect on Alzheimer’s as the APOE4 gene, which was linked to the disease in the 1990s. APOE4 accounts for about 20 percent of cases, while the strongest of the new genes accounts for, at most, 8 percent of cases.

The significance of the discovery lies instead in the number of possible new drug targets revealed by the study, including some that are involved in processes never before considered in Alzheimer’s.

“Six of our new genes suggest the existence of new pathways underlying Alzheimer’s,” Mayeux says. These areas include the junction between neurons in the hippocampus, the area of the brain where Alzheimer’s begins, and the activity of other cells in the brain surrounding the neurons.

Other new genes uncovered by the group are related to processes in the brain that are well-known contributors to Alzheimer’s, including the processes that lead to the build-up of toxic amyloid beta and tau deposits, or help confirm newer ideas such as inflammation. The identification of new genes involved in these processes may ultimately lead to new drugs.

What’s most needed now, the investigators say, is an intense effort to understand the precise roles of all 22 genes in the development of Alzheimer’s disease.

“At the end of the day, we want to find a way to halt or prevent the disease,” Mayeux says.  “The prospects of doing this are now somewhat greater, but we still have a lot of work to do.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

DNA Abnormalities Found in Children with Chronic Kidney Disease
Routine genetic screening of children with CKD could lead to earlier, more precise diagnoses.
Tuesday, April 21, 2015
Patient-Specific Stem Cells and Personalized Gene Therapy
Patients’ own cells transformed into model for studying disease and developing potential treatment.
Saturday, July 12, 2014
Test Could Identify Which Prostate Cancers Require Treatment
3-gene biomarker gauges tumor’s aggressiveness.
Thursday, September 12, 2013
Scientific News
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Personalized Drug Screening for Multiple Myeloma Patients
A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
New Way to Force Stem Cells to Become Bone Cells
Potential therapies based on this discovery could help people heal bone injuries or set hardware, such as replacement knees and hips.
Promise of Newborn Stem Cells to Revolutionize Clinical Practice
In this article Shweta Sharma, PhD, discusses the potential of an Umbilical Cord Blood bank as an untapped source of samples for research and clinical trials.
New Anti-Malarial Drug Screening Model
University of South Florida researchers demonstrate novel chemogenomic profiling to identify drug targets for the most lethal strain of malaria.
Coronavirus Breakthrough
Protein mutation affects spread and virulence of respiratory virus.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos