Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Genetic Mutation Helps Explain Development of Eczema

Published: Monday, November 04, 2013
Last Updated: Monday, November 04, 2013
Bookmark and Share
Researchers found that a mutation in the gene Matt/Tmem79 led to the development of spontaneous dermatitis in mice.

Scientists collaborating on an international research project led by Trinity College Dublin and the University of Dundee have identified a new genetic mutation linked to the development of a type of eczema known as atopic dermatitis (AD).

The gene, Matt/Tmem79, is involved in producing a protein, now called ‘mattrin’. However, protein expression was defective in individuals with the mutant gene, and this led to skin problems. In humans, mattrin is expressed within the cells that produce and maintain the skin’s function as a barrier. 

After identifying the relationship between the mutation and AD, the scientists looked for a similar pattern in people. They screened large cohorts of patients that suffered from AD, comparing them with unaffected control patients, and found that the equivalent human gene MATT/TMEM79 was similarly associated. The results of this study are published in the November issue of the leading peer-reviewed journal in allergy research, The Journal of Allergy and Clinical Immunology.

Professor Padraic Fallon, Chair of Translational Immunology in the School of Medicine at Trinity, who led the project, said:  “We have identified a new gene mutation that leads to atopic dermatitis (AD) in mice, and have taken that work further to demonstrate that a variant of the human gene is associated with AD in patients.”

Professor Fallon added: “This study highlights the value of research in which genetic patterns in animals provide a starting point to investigating human disease. This strategy enables us to identify new genes that are relevant in human disease and then examine the function of these genes during inflammation. This approach will ultimately help us to understand the factors leading to inflammatory diseases and assist in the development of new therapeutic strategies.”

Professor Irwin McLean, Scientific Director of the Centre for Dermatology and Genetic Medicine at the University of Dundee, jointly led the research that involved collaboration between scientists in Ireland, the United Kingdom, USA, Germany and Singapore. The work was funded by grants from the Wellcome Trust, Science Foundation Ireland and the National Children’s Research Centre.

Professor McLean added: “This study shows that disruption of the barrier function of the skin is a key driving force in the development of eczema.  Without an intact skin barrier, foreign substances can enter the body and trigger inflammation and allergy.”

AD is the most commonly diagnosed skin condition, affecting up to 20% of children. As well as having a genetic basis, the condition can also be triggered by environmental factors, such as pet fur, pollen and house dustmites. Dairy products, eggs, nuts and wheat have also been linked to the condition.

The article can be accessed online using the link below. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genetic Mutation Could Increase Understanding of ADHD
Absence of normal gene that expresses a protein involved in nerve cell communication results in seizures and hyperactivity.
Wednesday, November 27, 2013
Scientific News
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
Autism and Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Number Of Known Genetic Risk Factors For Endometrial Cancer Doubled
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
Genetic Risk Factors of Disparate Diseases Share Similar Biological Underpinnings
Penn Institute for Biomedical Informatics and colleagues identify "roadmap" of disease mechanisms to identify candidate drug targets.
Childhood Asthma Research Receives $2M
Research into the impact of a child’s upbringing and social and physical environments on the development of asthma will receive $2 million to tackle the condition that affects as many as one in three Canadians.
Making Precision Medicine a Reality
Researchers are one step closer to understanding the genetic and biological basis of diseases like cancer, diabetes, Alzheimer’s and rheumatoid arthritis – and identifying new drug targets and therapies.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!