Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Discovered a Mechanism that Induces Migration of Tumor Cells in Liver Cancer

Published: Wednesday, November 06, 2013
Last Updated: Wednesday, November 06, 2013
Bookmark and Share
Coordinated overactivation of TGFb and CXCR4 signaling pathways confer migratory properties to the hepatocellular carcinoma cells.

Researchers from the Biological clues of the invasive and metastatic phenotype group of the Bellvitge Biomedical Research Institute (IDIBELL) led by Isabel Fabregat have discovered the relationship between the TGFb signalling pathways and CXCR4 in hepatocellular carcinoma (HCC) . The cytokine TGFb is dependent of CXCR4 to induce tumor cell migratory ability.

The results of the study are published in the online edition of the journal Hepatology.

Dual function of TGFb

TGFb is a cytokine which in normal conditions and in very early stages of tumorigenesis acts as a tumor suppressor and that inhibits growth and induces cell death. However, as the tumor progresses, the cells acquire mutations or epigenetic alterations that allow them to overcome the suppressive effect of TGFb and respond to this cytokine acquiring a mesenchymal phenotype cells that confers them an increased migratory capacity , very important phenomenon in the tumor metastasis.

"Recently," explained Isabel Fabregat "several research groups are working on finding drugs that inhibit TGFb pathway. But it is important to establish parameters that allow us to predict whether a tumor will respond to TGFb inhibition so as to control tumor progression or whether on the contrary the answer is tumor growth. "

TGFb and CXCR4 relationship
 
In this regard, the study results show that some cell lines of hepatocellular carcinoma (HCC) have overactivated TGFb pathway (by increasing the production of this factor) and always correlate with greater capacity cell migration. An important aspect of the study was the demonstration that this ability depends on another pathway:  CXCR4 protein whose expression is dependent on TGFb. The researchers found that inhibition of CXCR4 blocks TGFb induced migration in tumor cells.

In vitro results were confirmed both in mouse models and in human samples from HCC. "When we analyzed CXCR4 levels in tissues of patients” explained Fabregat "we observed that high levels of this protein correlate always with overactivation of the TGFb pathway and, most interestingly, these patients had a tumor cell phenotype less differentiated, and potentially more aggressive . Moreover, CXCR4 was located preferentially in the areas of tumor invasion.”

 Future clinical application

 "At clinical level," explains the researcher "we believe that patients that reveal an overactivation of TGFb coincident with high expression of CXCR4 in tumor invasion fronts, may be candidates for TGFb inhibitory potential therapies.”

This study was conducted in collaboration with Emilio Ramos of liver surgery unit and Teresa Serrano pathology unit of the University Hospital of Bellvitge. "Our group performs a very basic research but through collaboration with clinicians have a more translational aspect because we can corroborate our results not only in animal models but also in human samples and study whether they can have an impact at the clinical level” said the researcher.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Keeping Growth in Check
Ribosomal proteins RPL5 and RPL11 play an essential role in normal cell proliferation.
Friday, December 13, 2013
Identified a Key Protein in Maintaining the Identity of B Lymphocytes
This finding could be useful for the study of blood diseases such as lymphoma and leukemia.
Monday, June 10, 2013
Ángel Carracedo: ''Only 50% of First-Line Drugs are Effective''
The Professor of Legal Medicine and director of the Genomic Medicine lab at the University of Santiago de Compostela, talked of the future challenges of the field of pharmacogenetics in the clinic.
Wednesday, March 20, 2013
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Making It Personal
Cancer vaccine linked to increased immune response against leukemia cells.
Protein-Based “Cancer Signature” Uncovered
Researchers investigated the expression of ribosomal proteins in human tissues and discovered a cancer type specific signature which could be used to predict the progression of the disease.
Blood-brain Barrier on a Chip
Researchers from Vanderbilt University have developed a microfluidic device to study the blood-brain barrier.
Genetic Links to Brain Cancer Cell Growth
Researchers discover clues to tumour behaviour from genetic differences between brain cancer cells and normal tissue cells.
Predicting Leukaemia Development in Cancer Patients
Biomarker may predict which formerly treated cancer patients will develop highly fatal form of leukemia.
Making Personalized Medicine a Reality
Groundbreaking technique developed at McMaster University is helping to pave the way for advances in personalized medicine.
Secret Phenotypes: Disease Devils in Invisible Details
Algorithmic deep phenotyping exposes masses of hidden traits and possible subtle genetic connections relevant to unseen influences on disease.
Hunting the Missing Link Between Genetics and the Environment
The International Phenome Centre Network (IPCN) works to transform healthcare through phenomics - the dynamic interactions between our genes and our environment.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!