Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Chemical Signature for Fast Form of Parkinson's Found

Published: Monday, November 25, 2013
Last Updated: Monday, November 25, 2013
Bookmark and Share
The physical decline experienced by Parkinson's disease patients eventually leads to disability and a lower quality of life.

Depending on the individual, the disorder can progress rapidly or slowly.

Scientists at UCLA and colleagues have now, for the first time, identified a biochemical signal in the blood associated with the faster-progressing form of Parkinson's. Such a biomarker could help doctors predict early on, just after the onset of motor symptoms, how rapidly the disease will progress. The researchers said they hope blood-based biomarkers like this one will aid in earlier detection and lead to more effective disease management.

The research findings appear in the online edition of the journal PLOS ONE.

Parkinson's disease is the second most common neurodegenerative disorder, afflicting more than 1 percent of all people over 60. Besides Parkinson's effects on walking, speaking and other motor functions, the disease also results in cognitive decline and depression. Further, it places a tremendous burden on caregivers and costs the U.S. an estimated $23 billion annually.

"The course of Parkinson's can be highly variable," said Dr. Beate Ritz, professor and chair of the department of epidemiology at UCLA's Fielding School of Public Health and one of the senior authors of the paper. "Some patients can become wheelchair-bound, demented or severely depressed within just a few years after diagnosis, while others are spared for longer periods."

For the study, the researchers initially drew blood samples from 250 Parkinson's patients in the early stages of the disease who were living the Central Valley region of California. These patients were then followed for five to 10 years. Forty of them were identified as having slow-progressing Parkinson's, and 40 had the fast-progressing form of the disease. Blood samples from patients in both groups were compared to samples from a group of 20 healthy individuals from the same area in California.

The researchers used high-resolution mass spectrometry to identify metabolic or chemical fingerprints in the blood. They discovered a potential biomarker for the fast-progressing type of Parkinson's disease. That biomarker, called N8-acetyl spermidine, was significantly elevated in the rapid progressors, compared with both the slow progressors and the healthy control subjects.

"This is an important step forward in understanding how Parkinson's evolves," said Ritz, who holds a joint appointment as a professor in the UCLA Department of Neurology. "Such biomarkers reflecting the pathogenesis of Parkinson's are greatly needed due to the fact that the degeneration of the neurons in the brain that produce dopamine - a hallmark of Parkinson's disease - is an irreversible process. In addition, that process begins up to 20 to 30 years before imaging can identify any brain changes.

"Our hope is that such biomarkers may aid in earlier detection and more effective disease management, and that they will lead to new prevention strategies and improved clinical trials for new treatments based on a better understanding of how the disease progresses."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
Thursday, May 19, 2016
Fructose Alters Hundreds of Brain Genes
UCLA scientists report that diet rich in omega-3 fatty acids can reverse the damage.
Tuesday, April 26, 2016
Study Yields the Key to Effective Personalized Medicine
A team of UCLA bioengineers and surgeons has taken a major step toward making personalized medicine a reality.
Monday, April 11, 2016
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Monday, February 08, 2016
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Monday, February 08, 2016
CRISPR-Cas9 Helps Uncover Genetics of Exotic Organisms
A new study illustrates the ease with which CRISPR-Cas9 can knock out genes in exotic animals to learn how those genes control growth and development.
Friday, December 11, 2015
‘Purity’ Of Tumor Samples May Significantly Bias Genomic Analyses
Non-cancerous tumor components influence research findings, clinical classifications, study shows.
Monday, December 07, 2015
Rare Childhood Leukemia Reveals Surprising Genetic Secrets
A coalition of leukemia researchers led by scientists from UC San Francisco has discovered surprising genetic diversity in juvenile myelomonocytic leukemia (JMML), a rare but aggressive childhood blood cancer.
Thursday, October 15, 2015
Engineers Crack DNA Code of Autoimmune Disorders
Researchers have identified an unexpectedly general set of rules that determine which molecules can cause the immune system to become vulnerable to the autoimmune disorders lupus and psoriasis.
Wednesday, June 10, 2015
May the Cellular Force be With You
Like tiny construction workers, cells sculpt embryonic tissues and organs in 3D space.
Friday, December 13, 2013
Researchers Un-Junking Junk DNA
A study shines a new light on molecular tools our cells use to govern regulated gene expression.
Wednesday, November 13, 2013
Did Inefficient Cellular Machinery Evolve to Fight Viruses and Jumping Genes?
UCSF scientist poses new theory on origins of eukaryotic gene expression.
Monday, November 11, 2013
Single Gene Mutation Linked to Neurological Disorders
Mutation could offer insights into Alzheimer’s, Parkinson’s and Huntigton’s Diseases.
Wednesday, October 16, 2013
Discovery Could Lead to Saliva Test for Pancreatic Cancer
The disease is typically diagnosed through an invasive and complicated biopsy.
Tuesday, October 15, 2013
Dentistry School Receives $5M to Study Saliva Biomarkers
Imagine having a sample of your saliva taken at the dentist's office, and then learning within minutes whether your risk for stomach cancer is higher than normal.
Thursday, August 15, 2013
Scientific News
Detecting Alzheimer's with Smell Test
Odour identification test may offer low-cost alternative for predicting cognitive decline and detecting early-stage Alzheimer’s disease.
Fighting Cancer Through Protein Pathways
Researchers have found a new drug target within a protein production pathway critical to regulating growth and proliferation of cells.
Ice Bucket Challenge Instrumental in Gene Discovery
Donations from the ALS Ice Bucket Chellenge allowed for the largest-ever study of inherited ALS, which identified a new ALS gene.
Cancer Gene-Drug Combinations Ripe for Precision Medicine
The study aims to expand the number of cancer gene mutations that can be paired with a precision therapy.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Disrupting Tumour-Promotion in Humans
Researchers have modified an existing protein to represses a specific cancer-promoting ‘message’ within cells.
Drug - Gene 'One-Two' Punch Against Cancer
Researchers identify gene-drug combinations that, together, target and kill cancer cells while not targeting healthy cells.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
Diagnostic Thread - Weaving the Future?
Researchers have created diagnostic threads that could pave the way for next-gen implantable and wearable diagnostics.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!