Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Research Point to Enzyme that Restores Function in Diabetic Kidney Disease

Published: Saturday, December 14, 2013
Last Updated: Sunday, December 15, 2013
Bookmark and Share
Data on recent kidney metabolomics findings discussed at the American Society of Nephrology Kidney Week Meeting.

ClinMet announced that researchers from The University of California, San Diego School of Medicine and colleagues have published new findings that could fundamentally change understanding of how diabetes-related diseases develop – and how they might be better treated. A prevailing theory suggests that mitochondrial function is overactive in diabetes and leads to complications such as kidney, eye, nerve and possibly cardiovascular disease. However, these new studies suggest that real-time production of superoxide – a marker of mitochondrial activity – is actually reduced, rather than elevated, in diabetic kidney disease and potentially other organs as well. Furthermore, stimulating mitochondrial production, function and superoxide levels led to improvement in diabetic kidney disease.

The new research, authored by UC San Diego professor and ClinMet scientific founder, Kumar Sharma, M.D., F.A.H.A (Director of the Center for Renal Translational Medicine, Division of Nephrology-Hypertension and the Institute of Metabolomic Medicine) and colleagues, was published online on October 25 in the Journal of Clinical Investigation. ClinMet has an exclusive license to use kidney metabolomics findings by Dr. Sharma and his team in drug development and other applications, based on patents filed by UC San Diego.

“These new data suggest that a major theory on the role of mitochondrial function in diabetic complications has to be questioned,” said Dr. Sharma. “In particular, our findings that an increase in mitochondrial function and superoxide production is associated with improvement in diabetic complications suggest that approaches to stimulate mitochondrial function may be beneficial as a new treatment for diabetic complications.”

“These key insights from a translational research perspective strongly support important concepts identified via metabolomics studies, as illustrated by Dr. Sharma’s publication earlier this month in the Journal of the American Society of Nephrology. They point to the utility of metabolomics technology, like that offered by ClinMet, to gain new insights about disease that can be further confirmed through translational animal studies,” commented Yesh Subramanian, President, Chief Executive Officer and co-founder of ClinMet.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Genes That Increase Children's Risk Of Blood Infection Identified
A team led by Oxford University has identified genes that make certain children more susceptible to invasive bacterial infections by performing a large genome-wide association study in African children.
Poverty Marks a Gene, Predicting Depression
New study of high-risk teens reveals a biological pathway for depression.
Early Genetic Changes in Premalignant Colorectal Tissue Identified
Findings point to drivers of early cancer development, targets for cancer prevention therapies.
A Guide to CRISPR Gene Activation
A comparison of synthetic gene-activating Cas9 proteins can help guide research and development of therapeutic approaches.
Gene That Lowers Heart Attack Risk Identified
Individuals with a rare twelve-letter deletion from a gene on chromosome 17 have significantly reduced non-HDL cholesterol levels and a 35% lower than average risk of heart disease.
"Sunscreen" Gene May Guard Against Melanoma
USC-led study reveals that melanoma patients with deficient or mutant copies of the gene are less protected from harmful ultraviolet rays.
Myeloid-Derived Suppressor Cells Play Role in Tumor Growth
Researchers at Baylor College of Medicine have reported a new mechanism that helps cancer cells engage myeloid-derived suppressor cells.
Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
Roundup Impacts Gene Expression
Study published on the impact of low-dose toxicity of Roundup weed-killer on gene expression profiles.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!