Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Proteomics Int'l Biomarker Study Closer to Diabetic Kidney Disease CDx Test

Published: Tuesday, April 15, 2014
Last Updated: Monday, April 28, 2014
Bookmark and Share
Company is seeking a commercialisation partner to enter the RUO, LDT or IVD markets.

Proteomics International has completed an important milestone towards the development of a companion diagnostic (CDx) test with the validation of several of its protein biomarkers.

The research team authenticated the panel of biomarkers after taking 508 highly curated disease and control samples. Seven biomarkers were validated at high stringency using the company's proprietary mass spectrometry approach.

The mass spectrometry data was then cross-validated using immunoassays in collaboration with the KTH Royal Institute of Technology, Sweden, and Merck Millipore. A further five biomarkers were validated at high stringency and these are available for out-licensing. The validation was supported by a grant from Commercialisation Australia.

Proteomics International managing director Richard Lipscombe said there was excellent correlation between the new mass spectrometry platform and the traditional gold standard test, essential because antibody assays are more readily accepted by the FDA. "By doing it as a diagnostic and showing that the whole approach works, we set the foundations to create tests for other medical conditions," Dr Lipscombe said.

The next stage of development is to create a test that can determine whether patients will get diabetic kidney disease before they develop the condition. "The Holy Grail is to predict who's going to get sick and who isn't and that's something that will come out of our study later in 2014." Dr Lipscombe said. "But in the short term we want a diagnostic test that is going to provide doctors with a more accurate, robust test."

The International Diabetes Foundation estimates that there are 382 million people living with diabetes and expect the number to rise significantly. Based on current statistics 10 to 15 per cent of all people with diabetes will die from kidney disease.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Growing Hepatitis C in the Lab
Recent discovery allows study of naturally occurring forms of hepatitis C virus (HCV) in the lab.
Signature of Microbiomes Linked to Schizophrenia
Studying microbiomes in throat may help identify causes and treatments of brain disorder.
Study Identifies the Off Switch for Biofilm Formation
New discovery could help prevent the formation of infectious bacterial films on hospital equipment.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Combo Tool
Joining molecular components expands ability to manipulate genes in specific cell types.
Team Identifies Structure of Tumor-Suppressing Protein
An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN.
Genes Associated With Improved Survival for Pancreatic Cancer Patients
Use of non-invasive liquid biopsies could predict in which patients the cancer could recur following surgery.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!