Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scripps Scientists Awarded NIH Grant for Biomarker Studies

Published: Tuesday, May 06, 2014
Last Updated: Tuesday, May 06, 2014
Bookmark and Share
$2.3 million grant awarded to develop new diagnostics for cancer, rheumatoid arthritis, colitis.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $2.3 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to develop new technology to diagnose cancer, rheumatoid arthritis and colitis.

Paul Thompson, a TSRI associate professor, will be the primary principal investigator for the four-year study.

“We’ve already identified a number of biomarkers for rheumatoid arthritis that we’re in the process of validating,” Thompson said. “The platform we are developing is faster and more versatile than existing technologies.”

Such biomarkers could allow for better, more individually tailored treatments because they could be used to diagnose and monitor disease progression or remission as patients experience different treatment options.

At the heart of the new study is a unique group of enzymes known as protein arginine deiminases (PAD). An increase in PAD activity has been noted in a number of conditions, such as inflammatory diseases like rheumatoid arthritis as well as cancer and Alzheimer’s disease.

PADs participate in reactions in the body that form the amino acid citrulline in proteins through a process known as citrullination, a modification that can have a significant impact on the structure and function of the modified proteins.

While the exact role of citrullination remains unknown, inhibition of citrullination in animal models, using a compound developed by Thompson, has been shown to alleviate the severity of rheumatoid arthritis, ulcerative colitis, atherosclerosis, lupus, nerve damage and cancer.

In addition to developing biomarkers, the scientists will use the grant to better understand this modification and whether it provides a common link among these disparate diseases.

The number of the grant is 1R01GM110394-01.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

TSRI Awarded $20M for Precision Medicine Initiative Cohort Program
NIH announces the first instalment of a $120M grant has been awarded to The Scripps Research Institute for its role in a national precision medicine initiative.
Monday, July 11, 2016
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Wednesday, June 29, 2016
Memory Suppressor Gene Identified
Scientists have identified a unique memory suppressor gene in the brain cells of Drosophila, the common fruit fly, a widely recognized substitute for human memory studies.
Tuesday, April 19, 2016
Chemists Devise Inexpensive, Benchtop Method for Marking and Selecting Cells
Chemists at The Scripps Research Institute have found an easier way to perform one of the most fundamental tasks in molecular biology.
Wednesday, January 16, 2013
Scripps Florida Scientists Create New Approach to Destroy Disease-Associated RNAs in Cells
As proof of principle, team creates molecule that corrects myotonic dystrophy in living cells.
Friday, December 21, 2012
Scientists Find Structure of a Protein that Makes Cancer Cells Resistant to Chemotherapy
A research team at the Scripps Research Institute has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells.
Monday, March 30, 2009
Scientific News
Detecting Alzheimer's with Smell Test
Odour identification test may offer low-cost alternative for predicting cognitive decline and detecting early-stage Alzheimer’s disease.
Fighting Cancer Through Protein Pathways
Researchers have found a new drug target within a protein production pathway critical to regulating growth and proliferation of cells.
Ice Bucket Challenge Instrumental in Gene Discovery
Donations from the ALS Ice Bucket Chellenge allowed for the largest-ever study of inherited ALS, which identified a new ALS gene.
Cancer Gene-Drug Combinations Ripe for Precision Medicine
The study aims to expand the number of cancer gene mutations that can be paired with a precision therapy.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Disrupting Tumour-Promotion in Humans
Researchers have modified an existing protein to represses a specific cancer-promoting ‘message’ within cells.
Drug - Gene 'One-Two' Punch Against Cancer
Researchers identify gene-drug combinations that, together, target and kill cancer cells while not targeting healthy cells.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
Diagnostic Thread - Weaving the Future?
Researchers have created diagnostic threads that could pave the way for next-gen implantable and wearable diagnostics.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!