Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Close in on Genes Responsible for Parkinson’s Disease

Published: Monday, December 19, 2005
Last Updated: Monday, December 19, 2005
Bookmark and Share
Findings could help doctors predict the likelihood of the disease developing, and provide targets for new treatments.

Scientists have identified 570 genes that act abnormally during the development of Parkinson’s Disease, a finding which could help doctors predict the likelihood of it developing, and provide targets for new treatments.

The research published in Neurogenetics, by the team from Imperial College London and the University of Liege, Belgium, uses microarrays to analyze brains from Parkinson’s patients.

Microarrays are laboratory chips able to pick out which genes are active when different processes are occurring in the brain. When they analyzed brains from people with Parkinson’s, they found that out of all 25,000 human genes, regulation of 570 was highly abnormal in Parkinson’s brains compared with non-diseased brains.

The researchers analyzed 23 brains from recently deceased patients, 15 affected by Parkinson’s and 8 control brains. The majority of brains were provided by the UK Parkinson’s Disease Society Tissue Bank at Imperial College London.

Dr Linda Moran from Imperial College London and one of the authors of the paper, said: “This research shows there are a considerable number of genes associated with the development of Parkinson’s, potentially providing new clues for how to treat this disease. Now that we can identify these genes it may be possible to develop new therapies to help the increasing numbers of Parkinson’s patients.”

The team, led by Professor Manuel Graeber, analyzed two parts of the brain which are affected by neurodegeneration in Parkinson’s; the substantia nigra in the mid-brain, and the cerebral cortex. They were able to eliminate around 15,000 genes from any role in Parkinson’s, as they were not found to be active in the substantia nigra, the part of the brain most affected by Parkinson’s.

Dawn Duke, MS, from Imperial College London, and one of the authors of the paper said: “In addition to identifying those genes linked with the development of Parkinson’s, this research has also shown that many of these genes were especially active in Parkinson’s brains. By limiting the activity of these genes, we may be able to control or even stop the development of Parkinson’s.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Gene Expression Controls Revealed
Researchers have modelled every atom in a key part of the process for switching on genes, revealing a whole new area for potential drug targets.
Tuesday, May 17, 2016
Breakthrough Could Lead to New Antibiotics
Scientists have exposed a chink in the armour of disease-causing bugs, with a new discovery about a protein that controls bacterial defences.
Friday, August 21, 2015
New Drug Target Identified for Serious Heart and Lung Condition
A gene has been identified that sheds new light on a potentially fatal heart and lung condition and could lead to a new treatment.
Friday, August 14, 2015
New Genetic Form of Obesity and Diabetes Discovered
Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.
Tuesday, June 30, 2015
New Genetic Form of Obesity and Diabetes Discovered
Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.
Tuesday, June 30, 2015
New 'Systems Genetics' Study Identifies Possible Target For Epilepsy Treatment
A single gene that coordinates a network of about 400 genes involved in epilepsy could be a target for new treatments, according to research.
Friday, January 23, 2015
Biomarker Discovery Sheds New Light on Heart Attack Risk of Arthritis Drugs
Drug may be given a new lease of life.
Thursday, December 11, 2014
Genetic Discovery Could Aid Diagnosis of Childhood TB
A distinctive genetic 'signature' found in the blood of children with TB offers new hope for improved diagnosis of the disease.
Thursday, May 01, 2014
Body Clock Receptor Linked to Diabetes in New Genetic Study
Study found that people who carry rare genetic mutations in the receptor for melatonin have higher risk of type 2 diabetes.
Tuesday, January 31, 2012
New Technology Could Slash Sequencing Time
Scientists from Imperial College London are developing technology that could ultimately sequence a person's genome in mere minutes, at a fraction of the cost of current commercial techniques.
Monday, December 20, 2010
Swine Flu: Early Findings about Pandemic Potential Reported in new Study
Early findings about the emerging pandemic of a new strain of influenza A (H1N1) in Mexico published in Science.
Tuesday, May 12, 2009
Study Suggests Listening to Pleasant Music Could Help Restore Vision in Stroke Patients
Patients who have lost part of their visual awareness following a stroke can show an improved ability to see when they are listening to music they like, according to a new study published in the journal Proceedings of the National Academy of Sciences.
Tuesday, March 24, 2009
Schizophrenia Linked to Signaling Problems in New Brain Study
The study supports the theory that abnormalities in the way in which cells 'talk' to each other are involved in the disease.
Wednesday, March 04, 2009
HIV Treatment Test Closer to Manufacture with new $7.3 Million Grant
The CD4 Initiative will use the grant received from Bill & Melinda Gates Foundation, to develop a point-of-care test for HIV/AIDS patients.
Wednesday, February 18, 2009
Alzheimer's Disease Patients Show Improvement in Trial of new Drug
A new drug has been shown to improve the brain function of Alzheimer's patients and reduce a key protein associated with the disease in the spinal fluid.
Wednesday, July 30, 2008
Scientific News
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
“Amazing Protein Diversity” Discovered in Maize
The genome of the corn plant – or maize, as it’s called almost everywhere except the US – “is a lot more exciting” than scientists have previously believed. So says the lead scientist in a new effort to analyze and annotate the depth of the plant’s genetic resources.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Revealing the Genetic Causes of Bowel Cancer
A landmark study has given the most detailed picture yet of the genetics of bowel cancer — the UK's fourth most common cancer.
Tumor Cells Develop Predictable Characteristics
Scientists have discovered that cancer cells at the edge of a tumor that are close to the surrounding environment are predictably different from the cells within the interior of the tumor.
New Imaging Method Reveals Nanoscale Details about DNA
Enhancement to super-resolution microscopy shows orientation of individual molecules, providing a new window into DNA’s structure and dynamics.
Genetic Research Can Significantly Improve Drug Development
With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!