Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Breast Cancer Researchers Call for Ethnicity to be Taken into Account When Developing Treatments

Published: Monday, July 21, 2008
Last Updated: Monday, July 21, 2008
Bookmark and Share
Breast cancer research needs to investigate how a person's ethnicity influences their response to treatment and its outcome, Imperial researchers say.

Breast cancer research needs to investigate how a person's ethnicity influences their response to treatment and its outcome, according to a new Comment piece in Lancet by researchers from Imperial College London.

Emerging evidence suggests that particular drugs may benefit people from one ethnic group more than others, because of differences in their genetic makeup. However, most key trials looking at treatments for breast cancer have been carried out in predominantly white populations in Europe, North America and Australasia.

Other populations might not respond to a drug in the same way as the white populations in these trials, argue the researchers.

They suggest that clinical trials should record participants' ethnicity and analyze whether there are differences in how patients from particular ethnic groups respond to a particular therapy.

The researchers highlight the example of a drug called trasztuzumab, which is commonly used to treat people with breast cancer that is HER-2 positive. Most studies of trasztuzumab have not reported the ethnicity of participants. However, a recent study showed that people with a particular genotype responded better than others to treatment with this drug.

The genotype in question is more common in some ethnic groups than in others, so the researchers argue that an individual's ethnicity could be a key factor in determining which treatments are most likely to benefit them.

Dr Carlo Palmieri, from the Division of Surgery, Oncology, Reproductive Biology and Anaesthetics at Imperial College London and one of the authors of the piece, said: "Everyone responds differently to treatment and it's often very difficult to predict how well someone will respond to a particular drug. However, evidence is now emerging that shows how your genes might influence whether or not a particular treatment can help you.

"There are small genetic differences between people from different ethnic backgrounds and it is really important that we find out whether these genetic differences mean that certain drugs perform well in people from certain ethnic groups but not in others. It's only by doing this that we can make sure each individual receives the best possible care," added Dr Palmieri.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Genetic Form of Obesity and Diabetes Discovered
Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.
Tuesday, June 30, 2015
New Genetic Form of Obesity and Diabetes Discovered
Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.
Tuesday, June 30, 2015
New 'Systems Genetics' Study Identifies Possible Target For Epilepsy Treatment
A single gene that coordinates a network of about 400 genes involved in epilepsy could be a target for new treatments, according to research.
Friday, January 23, 2015
Biomarker Discovery Sheds New Light on Heart Attack Risk of Arthritis Drugs
Drug may be given a new lease of life.
Thursday, December 11, 2014
Genetic Discovery Could Aid Diagnosis of Childhood TB
A distinctive genetic 'signature' found in the blood of children with TB offers new hope for improved diagnosis of the disease.
Thursday, May 01, 2014
Body Clock Receptor Linked to Diabetes in New Genetic Study
Study found that people who carry rare genetic mutations in the receptor for melatonin have higher risk of type 2 diabetes.
Tuesday, January 31, 2012
New Technology Could Slash Sequencing Time
Scientists from Imperial College London are developing technology that could ultimately sequence a person's genome in mere minutes, at a fraction of the cost of current commercial techniques.
Monday, December 20, 2010
Swine Flu: Early Findings about Pandemic Potential Reported in new Study
Early findings about the emerging pandemic of a new strain of influenza A (H1N1) in Mexico published in Science.
Tuesday, May 12, 2009
Study Suggests Listening to Pleasant Music Could Help Restore Vision in Stroke Patients
Patients who have lost part of their visual awareness following a stroke can show an improved ability to see when they are listening to music they like, according to a new study published in the journal Proceedings of the National Academy of Sciences.
Tuesday, March 24, 2009
Schizophrenia Linked to Signaling Problems in New Brain Study
The study supports the theory that abnormalities in the way in which cells 'talk' to each other are involved in the disease.
Wednesday, March 04, 2009
HIV Treatment Test Closer to Manufacture with new $7.3 Million Grant
The CD4 Initiative will use the grant received from Bill & Melinda Gates Foundation, to develop a point-of-care test for HIV/AIDS patients.
Wednesday, February 18, 2009
Alzheimer's Disease Patients Show Improvement in Trial of new Drug
A new drug has been shown to improve the brain function of Alzheimer's patients and reduce a key protein associated with the disease in the spinal fluid.
Wednesday, July 30, 2008
Gene Sequence that can make Half of us Fatter is Discovered
Researchers have found a gene sequence linked to an expanding waist line, weight gain and a tendency to develop type 2 diabetes.
Monday, May 05, 2008
New Targeted Approach to Light-Activated Cancer Drugs
Combining light-activated cancer drugs with tumor-seeking antibodies could provide a more effective way of treating many cancers, according to new research.
Monday, November 12, 2007
Scientists Develop Concept with Potential to Help Predict how Individuals may Respond to Drugs
The method is expected to be synergistic with existing pharmacogenomic approaches.
Tuesday, April 25, 2006
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Study Sheds Light on the Causes of Cerebral Palsy
Wider use of genetic testing in children with CP should be considered.
New Biosensors for Managing Microbial ‘Workers’
Researchers at Harvard’s Wyss Institute have unveiled new biosensors that enable scientists to more effectively control and 'communicate with' engineered bacteria.
Protein Related to Long Term Traumatic Brain Injury Complications Discovered
NIH-study shows protein found at higher levels in military members who have suffered multiple TBIs.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Cell Aging Slowed by Putting Brakes on Noisy Transcription
Experiments in yeast hint at ways to extend life of some human cells.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!