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Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes
Tulupova E., Kumar R.*, Slyskova J., Pardini B., Polakova V., Naccarati A., Vodickova L., Novotny J.**, Hemminki K.*, Vodicka P.

A role of mismatch repair (MMR) in modulating colorectal cancer (CRC) was assessed by genotyping single nucleotide polymorphisms in five MMR genes in hospital-based case- control study. The TAG haplotype in hMSH6 (-556G>T-Ex1-145G>-IVS4-101G>C) decreased a risk of CRC and the GGG haplotype increased a risk of rectal cancer. Although no significant association was found for individual MMR polymorphisms, the hMSH6 haplotypes may modulate the risk of CRC in this population.

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Targeting Inflammatory Cytokines Using Adenoviruses: gene delivery of biological therapies in ovarian cancer
Michael A. Salako, Hagen Kulbe, Iain A. McNeish, Frances R. Balkwill

Constitutive TNF-alpha expression is characteristic of the malignant ovarian surface epithelium. Adenoviral mutants hold great promise as gene therapy vectors but their efficacy is hindered by an inflammatory cascade orchestrated by TNF-alpha. We found that delivering TNF-alpha shRNA to ovarian cancer cells using oncolytic adenoviruses could reduce the inflammatory cascade generated by adenoviruses and also had direct anti-tumour activity on the cancer cells.

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INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Thomas V Paul*, Ben Selvan**, Jubbin Jacob*, Aravindan Nair** Esther Evelyn J*, Nihal Thomas*,Simon Rajaratnam*, Senthil Vasan K*, M.S.Seshadri*

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004

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INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Thomas V Paul*, Ben Selvan**, Jubbin Jacob*, Aravindan Nair** Esther Evelyn J*, Nihal Thomas*,Simon Rajaratnam*, Senthil Vasan K*, M.S.Seshadri*

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004

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INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Thomas V Paul, Ben Selvan, Jubbin Jacob, Aravindan Nair, Esther Evelyn J, Nihal Thomas, Simon Rajaratnam, Senthil Vasan K, M.S.Seshadri

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004

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Bayesian Parameter Estimation for Systems Biological Models of Dynamic Cellular Networks
Jarad Niemi, Lingchong You and Mike West

Dynamic cellular networks determine production of proteins in the cells in our body. The Rb-E2F network is a key example: it controls cell cycle, proliferation and degradation - a key network in almost all cancers. We develop statistical models of such single-cell processes - fine-time scale dynamic network models. Model estimation requires informative priors and custom Metropolis proposals.

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Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
Marlene Lopes, Nelma Gomes, Manuel Mota, Isabel Belo

In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.

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Treatment of Highland Frogs from the Two Legged Stage with Homeopathically Prepared Thyroxin (10-11 – 10-21)
Gerhard Lingg1, P. Christian Endler1,*, Michael Frass1, and Harald Lothaller2

For the experiment presented here, we used the same setup as for the initial multilaboratory study[1,2,3,4], but a special preparation process of the homeopathic drug involving dilution steps of 1: 50,000 and leading to thyroxin 10–11 – 10–21 was used.

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A high-throughput protein array-based approach
Rachel Van Dyk, Claudia Kirisits, Paul Potter, Fook Tim Chew, Reinhard Hiller

Here we present a novel discovery-oriented high-throughput approach to the screening of allergen reactivates in crude biological extracts is presented using seafood allergens as an example. The CPGR workflow permits the effective screening of hundreds of putative allergens in parallel using minute amounts of patient serum and constitutes a cost-efficient allergen-specific antibody screening method for a routine diagnostic setting.

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Showing Results 91 - 100 of 153
Scientific News
Breakthrough in Managing Yellow Fever Disease
UC Riverside-led research could lead to antiviral therapeutics and better diagnostics to prevent spread of potentially fatal viral infection.
Almac Announces Launch of CLIA Validated Next Generation Sequencing Assay
P53 considered important biomarker for cancer drug discovery.
Blood Test Could Reduce Antibiotic Use
A new blood biomarker test that indicates whether bacteria is the cause of a patient’s lung infection is now being studied at UPMC Presbyterian.
Light Shed On Genetic Architecture Of Kidney Cancer
Research reveals link between renal cell carcinoma and exposure to aristolochic acid.
Classification of Gene Mutations in Neuroblastoma
Penn Medicine and CHOP experts define riskier mutations in neuroblastoma, setting stage for clinical trial.
Typhoid Gene Unravelled
Natural resistance against typhoid fever is linked to a particular form of the HLA-DRB1 gene.
New Genetic Cause of Epilepsy Identified
San Diego girl improves after discovery of DNA mutation tied to potassium regulation.
First Atlas of Body Clock Gene Expression in Mammals Informs Timing of Drug Delivery
Penn Medicine study has implications for 100 top-selling US drugs, half of which target daily-oscillating genes.
Single Gene Mutation Eliminates ISG15
Single gene links susceptibility to rare infections with predisposition to autoimmune disease.
New Technique Yields Drug, Biomedical Test Results in One Minute
Slug flow microextraction makes it possible to quickly detect the presence of drugs or to monitor certain medical conditions using only a single drop of blood or urine.
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