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Two-Dimensional Molecular Profiling of Multiple Myeloma
Zelena Jana, Konecna Hana, Zdrahal Zbynek, Penka Miroslav and Hajek Roman

We have compared two different solubilization buffers, we also evaluated protein precipitation with ethanol and optimized 2-DE conditions for human myeloma proteins.

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Proteomic Approach to Identify Stage Specific Biomarkers in Streptozotocin Induced Diabetic Nephropathy
Vikram Sharma and Kulbhushan Tikoo

The presence of albumin in the urine of healthy subjects presents a stumbling block in diagnostics putting a question mark on the validity of albumin test for the detection of diabetic nephropathy. Therefore there arises a dire need to hunt for the proteins in the pertinent bio- fluids which can serve as biomarkers.

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Development of Biomarkers for Improved Diagnosis of Active Tuberculosis
Sybille Hunt, Amirkhani A, Cole R, Harcourt R,Hsu M , Marlborough D, Pedersen S, Qiu J, Ranaweera S, Remediakis C, Richards E, SeroaL, Sharp-Paul I, Sloane A, Vizgoft J, Harry J, Lindner R.

Proteome Systems has identified TB proteins in sputa and blood of people diagnosed with TB. Several of these proteins have been prioritised for ongoing validation. This involves generation of sensitive antibodies and optimisation of assays for detection of TB antigens in clinical samples. This presentation will discuss our progress in this program and our strategy for incorporation of these markers into a diagnostic test format.

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Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-fFxed Paraffin-Embedded (FFPE) Material using ULS Labeling
Saskia Schoenmakers, Dennis Postma, Marie Lacombe and Frank Opdam

Protein was extracted from 7-year old FFPE samples of B-cell lymphoma and mamma carcinoma, followed by ULS labeling. Samples were used for single or two color assays using a custom-made antibody array. We observed differential expression levels for several captured analytes. In B-cell lymphoma, expected high levels of IgM were detected, while high levels of CA19-9, a putative marker, were found for the breast cancer tissue.

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Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-Fixed Paraffin-Embedded (FFPE) Material using ULS Labeling
Saskia Schoenmakers, Dennis Postma, Marie Lacombe and Frank Opdam

Protein was extracted from 7-year old FFPE samples of B-cell lymphoma and mamma carcinoma, followed by ULS labeling. Samples were used for single or two color assays using a custom-made antibody array. We observed differential expression levels for several captured analytes. In B-cell lymphoma, expected high levels of IgM were detected, while high levels of CA19-9, a putative marker, were found for the breast cancer tissue.

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Interactive Transcription Maps Over Microarray Data
Petr Krontorad, Irena Koutna and Michal Strehovsky

For final description of microarray experiment results it is necessary to use some statistically robust method. Transcription maps (TM) are used to map results of gene expression analysis into individual chromosomes. We have implemented graphical tool for interactive display of TMs. This tool allows displaying of arbitrary information for each gene.

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Whole Body Endogenous Nitric Oxide Production in Patients with Decompensated Liver Disease
Demoncheaux E., Elphick D.A., Dürner M.B., Higgins G.E., Crowther D., Williams E.J., Higenbottam T.W and Gleeson D

Increased nitric oxide (NO) production has been implicated in the pathogenesis of the hyperdynamic circulation found in patients with advanced liver disease. There were no differences between patients with liver disease and controls with regard whole body NO production. Our results, in a well characterised set of patients, argue against greater basal NOS-dependent whole body NO production in patients with decompensated liver disease.

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Expression Profiling of CD34+ of Peripheral Blood of Patients with Lymphoma During ex vivo Granulocytic Differentiation
Irena Koutna, Lenka Tesarova, Martin Klabusay, Petr Krontorad, Michal Strehovsky, Martina Peterkova and Viera Hrabcakova

On the basis of global expression data analysis we have concluded that population of CD34+ cells from patients with lymphoma shows different expression status during ex-vivo differentiation. And thus we assume that CD34+ population is not suitable for autologous transplantation. We have used cDNA microarrays technology to obtained precise expression profiles.

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MS-Xelerator™: Advanced Algorithms for LC/MS Data Processing Applied to Biomarker Discovery, Differential Analysis and Quantitative Proteomics
M.M.A. Ruijken

LC-MS based proteomic experiments are used to compare complex biological samples across multiple conditions. Fast, powerful computational tools are needed to explore and detect differences in the areas of Expression Proteomics and Biomarker Discovery. In general, specialized steps are necessary to solve these difficult problems (binning, alignment & normalization, peak picking, relative quantitation, etc.). MS-Xelerator is a collection of software tools dedicated to all of the above tasks.

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Showing Results 91 - 100 of 134
Scientific News
Blood Test To Diagnose Depression
Test identifies nine blood markers tied to depression; predicts who will benefit from therapy.
Genetic Testing for Prostate Cancer
Genetic testing can identify men at six-fold increased risk of prostate cancer.
Zebrafish Genes Linked To Human Respiratory Diseases
Genes have been discovered which may be synonymous with the genes for developing hair-like structures in the human airway.
Ancient Vertebrate Uses Familiar Tools
Sea lamprey studies show remarkably conserved gene expression patterns in jawless versus jawed vertebrates.
Study Aims to Develop Breath Test for COPD
A new clinical iniative, lead by NYU Langone Medical Center, aims to determine a breath test’s effectiveness to identify volatile organic compounds (VOCs) in human breath that are biomarkers of chronic obstructive pulmonary disease (COPD).
Clinical Utility of Myriad myPath(TM) Melanoma Test Demonstrated
Test reduced indeterminate cases by 76 percent and changed treatment in 35 percent of cases.
In Directing Stem Cells, Context Matters
The surface cells are grown on has a profound effect on differentiation.
New Gene Mutations for Wilms Tumor
UT Southwestern researchers identified the mutated genes by sequencing the DNA of 44 tumors.
‘Switching off’ Autoimmune Diseases
Scientists have made an important breakthrough in the fight against debilitating autoimmune diseases by revealing how to stop cells attacking healthy body tissue.
Repressing the Repressors May Drive Tissue-Specific Cancers
Stowers scientists establish Drosophila and mammalian models to study mutations found in pediatric brain tumors.
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