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INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Thomas V Paul*, Ben Selvan**, Jubbin Jacob*, Aravindan Nair** Esther Evelyn J*, Nihal Thomas*,Simon Rajaratnam*, Senthil Vasan K*, M.S.Seshadri*

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004

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INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Thomas V Paul, Ben Selvan, Jubbin Jacob, Aravindan Nair, Esther Evelyn J, Nihal Thomas, Simon Rajaratnam, Senthil Vasan K, M.S.Seshadri

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004

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Bayesian Parameter Estimation for Systems Biological Models of Dynamic Cellular Networks
Jarad Niemi, Lingchong You and Mike West

Dynamic cellular networks determine production of proteins in the cells in our body. The Rb-E2F network is a key example: it controls cell cycle, proliferation and degradation - a key network in almost all cancers. We develop statistical models of such single-cell processes - fine-time scale dynamic network models. Model estimation requires informative priors and custom Metropolis proposals.

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Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
Marlene Lopes, Nelma Gomes, Manuel Mota, Isabel Belo

In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.

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Treatment of Highland Frogs from the Two Legged Stage with Homeopathically Prepared Thyroxin (10-11 – 10-21)
Gerhard Lingg1, P. Christian Endler1,*, Michael Frass1, and Harald Lothaller2

For the experiment presented here, we used the same setup as for the initial multilaboratory study[1,2,3,4], but a special preparation process of the homeopathic drug involving dilution steps of 1: 50,000 and leading to thyroxin 10–11 – 10–21 was used.

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A high-throughput protein array-based approach
Rachel Van Dyk, Claudia Kirisits, Paul Potter, Fook Tim Chew, Reinhard Hiller

Here we present a novel discovery-oriented high-throughput approach to the screening of allergen reactivates in crude biological extracts is presented using seafood allergens as an example. The CPGR workflow permits the effective screening of hundreds of putative allergens in parallel using minute amounts of patient serum and constitutes a cost-efficient allergen-specific antibody screening method for a routine diagnostic setting.

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Effects of cannabinoids on cholinergic-mediated contraction of human bronchi
Stanislas Grassin Delyle, Emmanuel Naline, Amparo Buenestado, Charles Advenier, Philippe Devillier

The current study was performed to investigate the role of cannabinoid (CB) receptors on the cholinergic contraction of isolated human airways. Results obtained with WIN55,212-2 (CB1/CB2 agonist), JWH-133 (CB2 agonist) and CB receptor selective antagonists suggest that CB1-receptor stimulation inhibits the cholinergic contraction in human isolated bronchi through stimulation of prejunctional receptors, located to post-ganglionic cholinergic nerves.

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DISTRIBUTION OF SAa2,6GAL AND SAa2,3GAL LINKED SURFACE RECEPTORS IN HUMAN RESPIRATORY TRACT AND ASSOCIATION WITH INFLUENZA VIRUS REPLICATION
Hsu, A.1,3, Grissell, T.1,3, Hansbro, P.2,3, Wark, PAB.1,3

To investigate the level of SAa2,6Gal and a2,3Gal linked receptors on human bronchial epithelial cells, and relate this to the ability of both human and avian influenza viruses to infect bronchial epithelial cells

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Accuwik® Ultra Membrane for the Direct Collection, Storage, and Efficient Rapid Release of Biological Samples for Clinical Diagnostics
Galina Fomovska, Stephane Perreault, Richmond Lo, and Martin A. Smith

Poster data assesses use of Pall’s Accuwik Ultra membrane as a reliable tool for direct collection of clinical samples including saliva and plasma, enables stability during sample storage, and allows for rapid and efficient release of clinically relevant protein biomarkers suitable for diagnostic analyses.

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Scientific News
Single Gene Mutation Eliminates ISG15
Single gene links susceptibility to rare infections with predisposition to autoimmune disease.
New Technique Yields Drug, Biomedical Test Results in One Minute
Slug flow microextraction makes it possible to quickly detect the presence of drugs or to monitor certain medical conditions using only a single drop of blood or urine.
New Clues For Early Colorectal Cancer Detection
Study identifies new biomarkers which could help detect colorectal cancer.
New 'Lab-on-a-Chip' Could Revolutionize Early Diagnosis of Cancer
Faster result times, reduced costs, minimal sample demands and better sensitivity of analysis.
Dramatic Response And Resistance To Cancer Drug Traced
Sequencing reveals why thyroid tumor responded to, and eventually resisted, treatment.
Personalized Ovarian Cancer Vaccines
UConn Researchers have found a new way to identify protein mutations in cancer cells.
NanoString, Brigham and Women’s Hospital Collaborate
Research collaboration to accelerate translation of genomic discoveries into clinical diagnostics in oncology.
Colorful Nanoprobes Make A Simple Test
Gold nanoparticles linked to single-stranded DNA create a simple but versatile genetic testing kit.
How Gene Expression Affects Facial Expressions
Researchers from USC have demonstrated how a mutation in TBX1 causes facial deformities associated with DiGeorge Syndrome.
Blood Test May Help Determine Psychosis Risk
A study led by University of North Carolina at Chapel Hill researchers represents an important step forward in the accurate diagnosis of people who are experiencing the earliest stages of psychosis.
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