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Panic attack and suicide risk: A multivariate logistic regression analysis of a national epidemiological survey
Curren Katz, Ramin Mojtabai, Leo Bierman, Kathleen Camacho, Janine Samuel, Gillian Jennings, Igor Galynker

To examine the relationship between panic attack and suicide risk, we analyzed data from a representative epidemiological survey of 43,093 adults (NESARC) using logistic regression controlling for socio-demographic and clinical variables. In depression, panic attacks are associated with increased odds of suicide attempt even after controlling for demographic and clinical variables. Furthermore, panic attacks can differentiate those who attempt suicide from those with ideation only.

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Panic attack and suicide risk: A multivariate logistic regression analysis of a national epidemiological survey
Curren Katz, Ramin Mojtabai, Leo Bierman, Kathleen Camacho, Janine Samuel, Gillian Jennings, Igor Galynker

To examine the relationship between panic attack and suicide risk, we analyzed data from a representative epidemiological survey of 43,093 adults (NESARC) using logistic regression controlling for socio-demographic and clinical variables. In depression, panic attacks are associated with increased odds of suicide attempt even after controlling for demographic and clinical variables. Furthermore, panic attacks can differentiate those who attempt suicide from those with ideation only.

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SYBR® Green I as a biomarker for schizophrenia
Davood Zaeifi, Mehdi Rahmati, Vahab Piranfar

The purpose of this study were to examine if the mRNA of the peripheral dopamine receptor is changed in schizophrenia patients. 50 Naive patients were enrolled. After extracting RNA from white blood cells, cDNA is synthesized. After doing the quantitative Real-time PCR, expression of D3 receptors in healthy persons and patients were compared. Results of this examinations reveals that expression of D3 receptor is increased in compared with controls sample.

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What reduces ambulatory sensitive hospitalisation?
Arindam Basu and David Brinson

This poster showcases our review of interventions that were found to be effective in reducing ambulatory sensitive hospitalisations (ASH). ASH refers to those conditions where hospitalisations an be avoided by measures taken by clinicians and other carers at outpatient departments or in the community.

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Anti-inflammatory activity of Dalbergia sissoo Roxb. heart-wood
Ohm Devani, S. K. Lahiri, D. D. Santani, M. B. Shah

The heart-wood of Dalbergia sissoo Roxb. is reported to be used in traditional medicinal practices, of which anti-inflammatory is one. The present work evaluates the effect of the heart-wood extract on the carrageenan induced rat paw edema. The drug was found to be active at lowest of 3 doses tried. the drug can be said to posses anti-inflamatory activity but needs further evaluation of discover the pathway of the same.

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Design and Fabrication of a Micro PCR Module for POC Applications
E. Morganti, C. Collini, C. Ress, A. Adami, L. Lorenzelli

The design and fabrication process of a micro PCR module is presented. The final system will be integrated in an innovative Lab on a Chip (LOC) to provide a technological platform able to detect autoimmune genetic diseases.

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Point-of-care testing for prostate cancer diagnosis
Y. Uludag; I.E. Tothill

This presentation describes the potential of using a new fully automated QCM biosensor and a commercial SPR biosensor for the detection of PSA, a biomarker for prostate cancer. Initially a new buffer was formulated to eliminate 98% of the non-specific human serum protein binding to the sensors. Obtained results indicate that both instruments can be used for the fast and easy detection of PSA (0.29-150 ng/ml) in serum.

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T cell response to cholera infection
Weil AA, Arifuzzaman M, Bhuiyan TR, Harris JB, Kendall EA, Hossain A, LaRocque RC, Harris AM, Tarique AA, Chowdhury F, Khan AI, Banerjee KK, Ryan ET, Qadri F, Calderwood SB

Natural Vibrio cholerae infection generates a robust B-cell response that wanes for T-cell independent antigens, suggesting that B-cell responses may be mediated in a T-cell dependent manner. Patients with cholera develop a memory-effector T-cell response to cholera antigens, and B-cell activation occurs after T-cell population expansion, suggesting that T-cells may play an important role in the development and maintenance of memory B-cell responses to T-cell dependent antigens.

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Resorufin - a lead for a new protein kinase CK2 inhibitor
Iben Skjøth Sandholt1, Birgitte Brinkmann Olsen1, Barbara Guerra1, Olaf-Georg Issinger1, Brigitte Boldyreff2

Screening of a natural compound library led to the identification of resorufin, as a highly selective and potent inhibitor for protein kinase CK2. Out of 52 kinases tested only CK2 was inhibited. The IC50 values determined for the CK2 holoenzymes were 1.5 µM and for the free catalytic subunits ca. 4 µM. In different cancer cell lines treatment with resorufin led to cell death and endogenous CK2 was inhibited.

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Showing Results 51 - 60 of 129
Scientific News
500 Million Year Reset for the Immune System
A single factor can reset the immune system of mice to a state likely similar to what it was 500 million years ago, when the first vertebrates emerged.
Pinpointing Genes that Protect Against Frailty
Researchers at Albert Einstein College of Medicine of Yeshiva University have been awarded a $3.3M grant from the NIH to study the role of genetics in protecting against frailty.
GTEx Project to Expand Functional Studies of Genomic Variation
Larger set of human tissues to be analyzed to contribute to a database and tissue bank that researchers can use to study how genomic variants influence gene activity.
Researchers Uncover New Cancer Cell Vulnerability
The research showed that telomerase-expressing cells depend upon a gene named p21 for their survival.
Capturing Cancer: A Powerful New Technique for Early Diagnosis
Researchers describe an innovative technique for early disease detection, which they call immunosignaturing.
No Extra Mutations in Modified Stem Cells, Study Finds
New results ease previous concerns that gene-editing techniques-used to develop therapies for genetic diseases-could add unwanted mutations to stem cells.
Patient-Specific Stem Cells and Personalized Gene Therapy
Patients’ own cells transformed into model for studying disease and developing potential treatment.
Significant Step Towards Blood Test for Alzheimer's
Scientists have identified a set of 10 proteins in the blood which can predict the onset of Alzheimer’s, marking a significant step towards developing a blood test for the disease.
Novel Insights into the Control of Gene Expression
The webinar, “Developing new insights into gene expression using RNA-Seq”, sees Dr Christopher Jones, Research Fellow at the Brighton and Sussex Medical School present novel findings from a recent RNA-Seq project performed by OGT.
Aging Contributes to Rapid Rates of Genomic Change
Signaling challenges for personalized medicine.
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