Idebenone Inhibits Cell Proliferation by Blocking of ANO1/ TMEM16A Chloride Channel in Adenocarcinoma Cells Yohan Seo
Idebenone significantly reduced cell proliferation and induced apoptosis in PC-3, CFPAC-1, HT-29, T-84 and Calu-3 cells having CaCCs activities. These data suggest that idebenone, an ANO1/CaCC inhibitor, has potential for use in cancer therapy.
Pressure-Based Volume Measurement Technology for In-process Measurement of Microplate Contents John Thomas Bradshaw, Bill Gigante, Christoph Schwedes
Modern drug discovery and research labs are utilizing complex automation systems to assist in high throughput screening of novel drug candidates. A large portion of these laboratories are using ANSI-SBS-standard 96- and 384-well plates to achieve the necessary throughput. The volume of sample transferred into and out of these plates can be critical to the success of assays or validation of procedures.
Validation of Collection and Extraction Methods of Saliva for Use in Biomarker Research Sarah E. Hurst and Brandon T. Hall
This poster investigates the collection and extraction methods of saliva for use in biomarker research.
Rapid Detection of Somatic Mutations in Cancer Genes Michael J. Powell et. al.,
Rapid higly sensitive detection of tumor gene mutations in DNA derived from FFPE or plasma samples can be achieved with QClamp PCR technology.
Accurate Normalization of Grain Samples Using Pressure-Based Volume Measurement Technology Bill Gigante, John Thomas Bradshaw, Tanya Knaide
A common challenge experienced by sample screening facilities is identifying individual sample quantity prior to DNA extraction. Accurately identifying sample quantity allows the user to pipette exact amounts of extraction buffer into each well.
Specificity of highly potent miRNA inhibitors Barbara Roberston, Andrew Dalby, Yuriy Fedorov, Jon Karpilow, Anastasia Khvorova, Devin Leake, Annaleen Vermeulen
Specificity of highly potent miRNA inhibitors
Expression of Wnt5a in Urothelial Carcinoma as a Potential Prognostic Marker Mark Saling 1, Jordan K. Duckett 1, Scott Jenkinson 2 and Ramiro Malgor 3
Our results support the previous studies that suggest Wnt5a plays a pathological role in urothelial carcinoma.
Automated detection and control of controlled substances Joe Bradley, Ian Johns
Scitegrity, in conjunction with the Pistoia Alliance and a number of pharmaceutical companies, have developed Controlled Substances Squared to scan large chemical libraries (millions of compounds) and determine whether a compound is considered as controlled in a selected country.
TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer Benjamin Otto1,2, Kristin Klätschke2, Thomas Streichert3, Christoph Wagener2, Genrich Tolstonog4
Here we aimed to investigate which molecular mechanisms are associated with TFAP2B expression in luminal breast cancer.