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ROLE OF IRF-8 IN THE INTERFACE OF MELANOMA TUMOR CELL-IMMUNE SYSTEM INTERACTION.
Fabrizio Mattei, Giovanna Schiavoni, Massimo Spada, Francesca Spadaro and Lucia Gabriele

Interferon-regulatory factor-8 is essential for differentiation and function of dendritic cells and thus for the induction of competent immune responses. Here, we investigated the role of IRF-8 in affecting immune response against melanoma. Our results reveal a critical role of IRF-8 in controlling melanoma growth and suggest that IRF-8-mediated antitumor activity is the result of a coordinated action between DC-mediated immune response and the tumor suppressor function of IRF-8.

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Software for Genomic/Epigenomic Research
A.S.Tanas, V.V.Shkarupo, E.B.Kuznetsova, D.V.Zaletayev, V.V. Strelnikov

We present two computer programs: 1) AIMS in silico - a suggestion tool for Amplification of Intermethylated Sites experimental design and results analysis; and 2) PeakPick – a tool to view & analyse capillary electrophoregrams Our computer software is intended to standardize AIMS applications and to turn it into one of the principal approaches towards cancer methylomes studies as well as towards diagnostics in oncology, including early screening.

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Geneset-based cancer survival analysis: On the non-uniform distributiuon of p-values under the null hypothesis
Esteban Czwan, Benedikt Brors, David Kipling

Although null p-values are assumed to be uniformly distributed in gene expression experiments, the actual distribution often deviates from the assumed distribution. This can incorrectly associate the biology of a geneset with cancer prognosis in geneset-based survival studies. To assess the implications of this, a geneset-based method was developed. This method empirically approximates the distribution of null p-values and tests whether predefined sets of biologically-related genes are associate

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Clinical Outcomes and Emerging Challenges after 5 years of ART in Khayelitsha, South Africa
Gilles Van Cutsem1, Katherine Hilderbrand1,2, David Coetzee2,3, Carol Cragg3, Eric Goemaere1 & Andrew Boulle2,3

One of the first primary care antiretroviral treatment programs in Africa shows good patient outcomes at 5 years. Saturation of services has led to increased losses to follow-up.

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Panic attack and suicide risk: A multivariate logistic regression analysis of a national epidemiological survey
Curren Katz, Ramin Mojtabai, Leo Bierman, Kathleen Camacho, Janine Samuel, Gillian Jennings, Igor Galynker

To examine the relationship between panic attack and suicide risk, we analyzed data from a representative epidemiological survey of 43,093 adults (NESARC) using logistic regression controlling for socio-demographic and clinical variables. In depression, panic attacks are associated with increased odds of suicide attempt even after controlling for demographic and clinical variables. Furthermore, panic attacks can differentiate those who attempt suicide from those with ideation only.

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Panic attack and suicide risk: A multivariate logistic regression analysis of a national epidemiological survey
Curren Katz, Ramin Mojtabai, Leo Bierman, Kathleen Camacho, Janine Samuel, Gillian Jennings, Igor Galynker

To examine the relationship between panic attack and suicide risk, we analyzed data from a representative epidemiological survey of 43,093 adults (NESARC) using logistic regression controlling for socio-demographic and clinical variables. In depression, panic attacks are associated with increased odds of suicide attempt even after controlling for demographic and clinical variables. Furthermore, panic attacks can differentiate those who attempt suicide from those with ideation only.

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SYBR® Green I as a biomarker for schizophrenia
Davood Zaeifi, Mehdi Rahmati, Vahab Piranfar

The purpose of this study were to examine if the mRNA of the peripheral dopamine receptor is changed in schizophrenia patients. 50 Naive patients were enrolled. After extracting RNA from white blood cells, cDNA is synthesized. After doing the quantitative Real-time PCR, expression of D3 receptors in healthy persons and patients were compared. Results of this examinations reveals that expression of D3 receptor is increased in compared with controls sample.

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What reduces ambulatory sensitive hospitalisation?
Arindam Basu and David Brinson

This poster showcases our review of interventions that were found to be effective in reducing ambulatory sensitive hospitalisations (ASH). ASH refers to those conditions where hospitalisations an be avoided by measures taken by clinicians and other carers at outpatient departments or in the community.

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Anti-inflammatory activity of Dalbergia sissoo Roxb. heart-wood
Ohm Devani, S. K. Lahiri, D. D. Santani, M. B. Shah

The heart-wood of Dalbergia sissoo Roxb. is reported to be used in traditional medicinal practices, of which anti-inflammatory is one. The present work evaluates the effect of the heart-wood extract on the carrageenan induced rat paw edema. The drug was found to be active at lowest of 3 doses tried. the drug can be said to posses anti-inflamatory activity but needs further evaluation of discover the pathway of the same.

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Showing Results 71 - 80 of 153
Scientific News
Breakthrough in Managing Yellow Fever Disease
UC Riverside-led research could lead to antiviral therapeutics and better diagnostics to prevent spread of potentially fatal viral infection.
Almac Announces Launch of CLIA Validated Next Generation Sequencing Assay
P53 considered important biomarker for cancer drug discovery.
Blood Test Could Reduce Antibiotic Use
A new blood biomarker test that indicates whether bacteria is the cause of a patient’s lung infection is now being studied at UPMC Presbyterian.
Light Shed On Genetic Architecture Of Kidney Cancer
Research reveals link between renal cell carcinoma and exposure to aristolochic acid.
Classification of Gene Mutations in Neuroblastoma
Penn Medicine and CHOP experts define riskier mutations in neuroblastoma, setting stage for clinical trial.
Typhoid Gene Unravelled
Natural resistance against typhoid fever is linked to a particular form of the HLA-DRB1 gene.
New Genetic Cause of Epilepsy Identified
San Diego girl improves after discovery of DNA mutation tied to potassium regulation.
First Atlas of Body Clock Gene Expression in Mammals Informs Timing of Drug Delivery
Penn Medicine study has implications for 100 top-selling US drugs, half of which target daily-oscillating genes.
Single Gene Mutation Eliminates ISG15
Single gene links susceptibility to rare infections with predisposition to autoimmune disease.
New Technique Yields Drug, Biomedical Test Results in One Minute
Slug flow microextraction makes it possible to quickly detect the presence of drugs or to monitor certain medical conditions using only a single drop of blood or urine.
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