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Wednesday, July 23, 2014
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Inflammatory Markers in Leg Ulcer Fluid from Chronic Venous Insufficiency
Monica Neagu, Gina Manda, Carolina Constantin, Ionela Neagoe*, Lucian Albulescu, Cristiana Tanase, Eleonora Codorean, Daniel Boda and Sanda Marta Popescu

The purpose of our study was to evaluate soluble matrixmetalloproteinases (MMPs) and their inhibitor (TIMP1) associated to leg ulcer wound fluid in comparison with the tissue localized ones. We aimed to develop an easy-to-perform protocol for the quantification of soluble MMPs / TIMP and associate the obtained levels with the disease stage and prognostic.

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Biomarker Discovery Strategy for Trisomy 21 Using iTRAQ and 4800 Plus MALDI TOF/TOF
Varaprasad Kolla

Plasma proteins serve as good indicators of disease as there are representative proteins from several cellular processes and thus a potential source for biomarker discovery. The large dynamic range of plasma proteins makes the analysis very challenging, as a large number of low abundance proteins are masked by a few high abundance proteins.

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Two-Dimensional Molecular Profiling of Multiple Myeloma
Zelena Jana, Konecna Hana, Zdrahal Zbynek, Penka Miroslav and Hajek Roman

We have compared two different solubilization buffers, we also evaluated protein precipitation with ethanol and optimized 2-DE conditions for human myeloma proteins.

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Proteomic Approach to Identify Stage Specific Biomarkers in Streptozotocin Induced Diabetic Nephropathy
Vikram Sharma and Kulbhushan Tikoo

The presence of albumin in the urine of healthy subjects presents a stumbling block in diagnostics putting a question mark on the validity of albumin test for the detection of diabetic nephropathy. Therefore there arises a dire need to hunt for the proteins in the pertinent bio- fluids which can serve as biomarkers.

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Development of Biomarkers for Improved Diagnosis of Active Tuberculosis
Sybille Hunt, Amirkhani A, Cole R, Harcourt R,Hsu M , Marlborough D, Pedersen S, Qiu J, Ranaweera S, Remediakis C, Richards E, SeroaL, Sharp-Paul I, Sloane A, Vizgoft J, Harry J, Lindner R.

Proteome Systems has identified TB proteins in sputa and blood of people diagnosed with TB. Several of these proteins have been prioritised for ongoing validation. This involves generation of sensitive antibodies and optimisation of assays for detection of TB antigens in clinical samples. This presentation will discuss our progress in this program and our strategy for incorporation of these markers into a diagnostic test format.

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Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-fFxed Paraffin-Embedded (FFPE) Material using ULS Labeling
Saskia Schoenmakers, Dennis Postma, Marie Lacombe and Frank Opdam

Protein was extracted from 7-year old FFPE samples of B-cell lymphoma and mamma carcinoma, followed by ULS labeling. Samples were used for single or two color assays using a custom-made antibody array. We observed differential expression levels for several captured analytes. In B-cell lymphoma, expected high levels of IgM were detected, while high levels of CA19-9, a putative marker, were found for the breast cancer tissue.

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Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-Fixed Paraffin-Embedded (FFPE) Material using ULS Labeling
Saskia Schoenmakers, Dennis Postma, Marie Lacombe and Frank Opdam

Protein was extracted from 7-year old FFPE samples of B-cell lymphoma and mamma carcinoma, followed by ULS labeling. Samples were used for single or two color assays using a custom-made antibody array. We observed differential expression levels for several captured analytes. In B-cell lymphoma, expected high levels of IgM were detected, while high levels of CA19-9, a putative marker, were found for the breast cancer tissue.

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Interactive Transcription Maps Over Microarray Data
Petr Krontorad, Irena Koutna and Michal Strehovsky

For final description of microarray experiment results it is necessary to use some statistically robust method. Transcription maps (TM) are used to map results of gene expression analysis into individual chromosomes. We have implemented graphical tool for interactive display of TMs. This tool allows displaying of arbitrary information for each gene.

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Whole Body Endogenous Nitric Oxide Production in Patients with Decompensated Liver Disease
Demoncheaux E., Elphick D.A., Dürner M.B., Higgins G.E., Crowther D., Williams E.J., Higenbottam T.W and Gleeson D

Increased nitric oxide (NO) production has been implicated in the pathogenesis of the hyperdynamic circulation found in patients with advanced liver disease. There were no differences between patients with liver disease and controls with regard whole body NO production. Our results, in a well characterised set of patients, argue against greater basal NOS-dependent whole body NO production in patients with decompensated liver disease.

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Showing Results 81 - 90 of 126
Scientific News
Researchers Uncover New Cancer Cell Vulnerability
The research showed that telomerase-expressing cells depend upon a gene named p21 for their survival.
Capturing Cancer: A Powerful New Technique for Early Diagnosis
Researchers describe an innovative technique for early disease detection, which they call immunosignaturing.
No Extra Mutations in Modified Stem Cells, Study Finds
New results ease previous concerns that gene-editing techniques-used to develop therapies for genetic diseases-could add unwanted mutations to stem cells.
Patient-Specific Stem Cells and Personalized Gene Therapy
Patients’ own cells transformed into model for studying disease and developing potential treatment.
Significant Step Towards Blood Test for Alzheimer's
Scientists have identified a set of 10 proteins in the blood which can predict the onset of Alzheimer’s, marking a significant step towards developing a blood test for the disease.
Novel Insights into the Control of Gene Expression
The webinar, “Developing new insights into gene expression using RNA-Seq”, sees Dr Christopher Jones, Research Fellow at the Brighton and Sussex Medical School present novel findings from a recent RNA-Seq project performed by OGT.
Aging Contributes to Rapid Rates of Genomic Change
Signaling challenges for personalized medicine.
CRI Finds Key to Identifying, Enriching Mesenchymal Stem Cells
Biomarker enables researchers to accurately characterize the properties and function of MSCs in the body.
Saturated Fat Intake May Influence Person’s Expression of Genetic Obesity Risk
Limiting saturated fat could help people whose genetic make-up increases their chance of being obese.
Genetic Material Hitchhiking in Our Cells May Shape Physical Traits
Explaining the connection between genotype and phenotype must also consider genetic material that doesn’t come from an organism’s chromosomes at all.
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