Transcriptional and Posttranscriptional Regulation of HIV-1 Gene ExpressionThe transcription factors that control YAP gene expression are unknown. This study demonstrates that ß-catenin/TCF4 complexes bind a DNA enhancer element within the first intron of the YAP gene to drive YAP expression in CRC cells.
Launch of DIRECT - An Innovative Medicines Initiative Project for Personalized Medicine in DiabetesAcademia and the pharmaceutical industry working together in the fight against diabetes.
Estimation of drug-metabolizing capacity by CYP-genotyping and CYP-expressionThe lack of therapeutic effect of drugs or the appearance of undesired side-effects is partly caused by differences or changes in drug metabolism. This work aims to introduce an approach of combining CYP-genotyping and CYP-phenotyping tools to estimate patients’ drug-metabolizing capacity.
Case Study Demonstrates Importance of MIQE for qPCR Data AnalysisPublished by Bio-Rad Laboratories, Inc. this case study demonstrates how real-time PCR can lead to erroneous conclusions if the key steps set out in the MIQE guidelines are not followed.
Transformational Fruit Fly Genome Catalog CompletedScientists now have a reference manual that should speed gene discoveries in everything from pest control to personalized medicine.
FDA Approves KALYDECO™ (ivacaftor), the First Medicine to Treat the Underlying Cause of Cystic FibrosisVertex Pharmaceuticals announces KALYDECO approved to treat people with CF who have a specific genetic mutation.
Body Clock Receptor Linked to Diabetes in New Genetic StudyStudy found that people who carry rare genetic mutations in the receptor for melatonin have higher risk of type 2 diabetes.
Pinpoint Genomics Announces Publication of Clinical Study Results in Lung CancerThe Pinpoint Dx Lung(TM) Assay is a molecular diagnostic assay that assesses the likelihood of death after lung cancer surgery.
OGT Releases New Whitepaper for Aiding Biomarker DiscoveryThe new document explores the need for biomarkers as indicators of disease, and discusses the vast potential of autoantibodies as markers of early disease development.
Scripps Research Scientists Create Novel RNA Repair TechnologyDiscovery could aid search for Huntington’s, Spinocerebellar Ataxia, and Kennedy Disease treatments.
