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Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Controlling RNA in Living Cells
Modular, programmable proteins can be used to track or manipulate gene expression.
Genetic Approach May Lead to New Treatments for Digestive Diseases
Researchers at UMass Medical School have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the digestive system.
Fructose Alters Hundreds of Brain Genes
UCLA scientists report that diet rich in omega-3 fatty acids can reverse the damage.
DNA Barcodes Gone Wild
A team of researchers at University of Toronto’s Donnelly Centre and Sinai Health System’s Lunenfeld-Tanenbaum Research Institute (LTRI) has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions.
New Genetic Risk Factors for Myopia Discovered
Genes and environment determine short-sightedness.
Targeting an ‘Undruggable’ Cancer Gene
RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers.
Biomarkers for Profiling Prostate Cancer Patients
Exiqon A/S has announced the publication of validation of prognostic microRNA biomarkers for the aggressiveness of prostate cancer in independent cohorts.
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Automating ELISAs on Tecan’s Freedom EVO® using Optimiser™ technology from Siloam Biosciences
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Tecan Group Ltd.

ELISAs are considered one of the most useful secondary or tertiary type assays in drug discovery, because they elucidate specific cellular pathways and associated mechanisms of action for target genes, proteins or small molecules. They are equally important to clinical biology laboratories, as they enable determination of biomarker concentrations in unknown biological samples.  

There have been a number of attempts to replace the traditional plate-based ELISA with microfluidic-based technology, but in general these have all suffered from the need for specialized liquid handling systems. Until now, microfluidic technology has not been adapted to the SBS plate footprint, and could not make use of the plate-based liquid handling and detection instrumentation found in many life science laboratories. 


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