Corporate Banner
Satellite Banner
Technology Networks Header
Tuesday, October 21, 2014
Technology Networks
 
Register | Sign in
Home Page > Videos > Single Cell Expression profiling
  Videos

Return

Single Cell Expression profiling
TATAA Biocenter

Mikael Kubista, Professor, TATAA Biocenter

Abstract
There is surprisingly large variation in the copy number of transcripts among even seemingly like cells. Under most conditions for essentially all genes and tissues the variation among cells for any given transcript can be fitted quite well with a log normal distribution. The variation is caused by transcriptional bursting, which is a dynamic process expected to be correlated for genes critical for the same cellular process. This leads to correlated expression levels of related genes among individual cells. Most genes do not have correlated expression on single cell level and it makes no sense normalizing single cell expression data to reference genes. Rather cells can be classified based on the correlated expression of important genes. In my talk I will show how such single cell expression correlation can be used to distinguish cells as well as cell subtypes. Finally, I show how to cope with genomic DNA background in expression profiling studies with the ValidPrime concept.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
Single Gene Mutation Eliminates ISG15
Single gene links susceptibility to rare infections with predisposition to autoimmune disease.
New Technique Yields Drug, Biomedical Test Results in One Minute
Slug flow microextraction makes it possible to quickly detect the presence of drugs or to monitor certain medical conditions using only a single drop of blood or urine.
New Clues For Early Colorectal Cancer Detection
Study identifies new biomarkers which could help detect colorectal cancer.
New 'Lab-on-a-Chip' Could Revolutionize Early Diagnosis of Cancer
Faster result times, reduced costs, minimal sample demands and better sensitivity of analysis.
Dramatic Response And Resistance To Cancer Drug Traced
Sequencing reveals why thyroid tumor responded to, and eventually resisted, treatment.
Personalized Ovarian Cancer Vaccines
UConn Researchers have found a new way to identify protein mutations in cancer cells.
NanoString, Brigham and Women’s Hospital Collaborate
Research collaboration to accelerate translation of genomic discoveries into clinical diagnostics in oncology.
Colorful Nanoprobes Make A Simple Test
Gold nanoparticles linked to single-stranded DNA create a simple but versatile genetic testing kit.
How Gene Expression Affects Facial Expressions
Researchers from USC have demonstrated how a mutation in TBX1 causes facial deformities associated with DiGeorge Syndrome.
Blood Test May Help Determine Psychosis Risk
A study led by University of North Carolina at Chapel Hill researchers represents an important step forward in the accurate diagnosis of people who are experiencing the earliest stages of psychosis.
Scroll Up
Scroll Down
Skyscraper Banner
Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv