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Quantification of Bacterial DNA for Meta...
World of Technology & Science 2014...MCA96 nested disposable tips Te-Stack...Early Transition Metal Chemistry in Flow...

Featured Products
Featured Product - Fluent™ – the new laboratory automation solution for cell-based assays from Tecan
Fluent™ – the new laboratory automation solution for cell-based assays from Tecan
Featured Product - Cell Voyager
Cell Voyager

Webcasts
Webcast - Pivot Park Screening Centre, The Pivot for Screening Knowledge and ExpertisePivot Park Screening Centre, The Pivot for Screening Knowledge and Expertise
Helma Rutjes, Pivot Park Screening Centre, speaking at Drug Discovery and Development 2014
Webcast - What Can We Learn from Fragment Based Optimization Programs?What Can We Learn from Fragment Based Optimization Programs?
Gyorgy Keseru, Hungarian Academy of Sciences, speaking at Drug Discovery and Development 2014

Market Reports
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
High Throughput Screening (HTS) Market by Technology, Applications, and End Users - Forecast to 2018
MarketsandMarkets

Technological advancements and flourishing outsourcing industry likely to propel the growth of the global high throughput screening market. In this report, the global high throughput screening market has been segmented on the basis of technology, products, applications, end users, and geography.
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
Automated Patch Clamping Trends 2014
HTStec

The objective of this global benchmarking study was to comprehensively document current practices, preferences and metrics in ion channel drug screening using APC technology. It also seeks to chart the emergence of new 384-well APC systems.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Academic Outreach & Non-Profit Screening Trends 2014
HTSTec

The main objectives of this global benchmarking study were to compile a report that comprehensively documents the current status, operational capabilities, interests, assay readouts, formats, funding, budgets, success criteria and future investments of academic and non-profit screening centers.
Mass Spectrometry Market by Technology & Application - Global Trends & Forecast to 2018
MarketsandMarkets

The global mass spectrometry market witnesses high competitive intensity as there are many big and small firms with similar product offerings. These companies adopt various strategies to increase their market shares and to establish a strong foothold in the global market.
Scientific News
New Research Unlocks a Mystery of Albinism
A team led by Brown University biologists has discovered the way in which a specific genetic mutation appears to lead to the lack of melanin production underlying a form of albinism.
Biomarker Discovery Sheds New Light on Heart Attack Risk of Arthritis Drugs
Drug may be given a new lease of life.
New Way To Turn Genes On
Technique allows rapid, large-scale studies of gene function.
Metal Test Could Help Diagnose Breast Cancer Early
It may be possible to develop a simple blood test that, by detecting changes in the zinc in our bodies, could help to diagnose breast cancer early.
Reducing Chemotherapy Drug’s Cardiac Side Effects
Preventing doxorubicin-induced cardiotoxicity could improve chemotherapy outcomes, reduce heart failure risk.
New Approach Holds Promise for Dengue Fever
An exclusive partnering deal to develop Fenretinide for dengue fever.
Stroke Damage Mechanism Identified
Researchers have discovered a mechanism linked to the brain damage often suffered by stroke victims—and are now searching for drugs to block it.
Two Studies Identify A Detectable, Pre-Cancerous State In The Blood
Findings pave way for new lines of cancer research focused on detection and prevention.
Antibiotic Resistance Threatens Future of Modern Medicine
Overuse and misuse of antibiotics, one of the key contributors to antimicrobial resistance (AMR).
Powerful Method To Speed Cancer Drug Discovery Unveiled
The new method lets researchers identify weak and previously undetectable interactions between proteins inside living cells.
Business News
25 Years of Revolutionary Microplate Reader Technology at the LS2
BMG LABTECH exhibits at the biggest Swiss Life Sciences Meeting for the first time.
OHSU and FEI Expand Living Lab with New Equipment for Cancer Research
Installation is part of an expansion of the OHSU/FEI Living Lab for Cell Biology collaboration.
Key US Patents Granted for GPCR-Focused Drug Discovery Platform
Structure-based drug discovery platform targets challenging GPCRs linked to human disease.
New Companies Join Cancer Research UK Consortium
Three new biomarker companies have been selected to work with the Early Diagnosis Consortium, a collaboration between Cancer Research UK, its commercial arm, Cancer Research Technology and Abcodia.
Sigma-Aldrich Licenses Foundational CRISPR Patents from Broad Institute
Company is able to make, use and distribute the advanced gene editing tools for numerous research applications.
ZoBio, Domainex Partner to support FORMA Therapeutics’ Drug Discovery Programs
ZoBio and Domainex Ltd. announce a collaboration with FORMA Therapeutics to provide NMR-based structural biology services for a substantial panel of FORMA drug targets.
Evotec and Sanofi Enter into Exclusive Negotiations
Goal to improve innovation effectiveness in drug discovery and pre-clinical development.
Horizon Discovery CEO Wins Executive of the Year
Darrin Disley wins Executive of the Year award at the SCRIP Awards.
Exiqon Licenses Biomarkers From Aarhus University Hospital
Exiqon A/S has exclusively licensed prostate cancer biomarkers discovered and validated by Aarhus University Hospital, Department of Molecular Medicine (MOMA).
BioVersys and Enamine Extend Collaboration
BioVersys and Enamine announce extension of drug discovery collaboration to address multidrug-resistant bacterial infections.

Events
Featured Event - 5th Clinical Quality Signals,
21 Jan 2015
5th Clinical Quality Signals, ...
Featured Event - RNA-Seq 2015
20 Jan 2015
RNA-Seq 2015 ...
Quantitative Systems Pharmacol
27 Jan 2015
Quantitative Systems Pharmacol ...
SLAS2015
07 Feb 2015
SLAS2015 ...

ePosters
Experimental Evolution in Diatoms - Thermal longterm acclimation in two model diatom species
1 University of East Anglia, School of Environmental Science, Norwich, UK 2Institute of Evolutionary Biology, University of Edinburgh, Kings Building, Ashworth Laboratories, West

Experimental Evolution in two model Diatoms
Antioxidant and Free Radicals Scavenging Activity of Biomolecules: Hydroxamic Acids
School of Study in Chemistry, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

In the present poster attention is focused towards the investigation of antioxidant and free radicals scavenging activity of N-aryl substituted hydroxamic acids by DPPH method which is based on the reduction of alcoholic DPPH solutions in presence of a hydrogen donating antioxidant, hydroxamic acids.
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis
Open University

The research reviews current knowledge of the genetic causes of Leber's congenital amaurosis (LCA) and the development of a gene therapy intervention for LCA. The efficacy as well as the limitations of this form of treatment are evaluated in detail and recommendations are made for the future directions of gene therapy for Leber's congenital amaurosis.

Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
(1) Izon Science US Ltd, Christchurch, New Zealand (2) The University of Queensland, Brisbane, QLD, Australia

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.
High Titre BacMam viruses improve transduction efficiency of mammalian cells
Oxford Expression Technologies Ltd, Oxford Brookes University

We present a method for producing high titre BacMam virus vectors for the efficient transduction of mammalian cells.
Novel Approaches to High-throughput Measurements of Replicative Lifespan in Yeast by Microfluidic Size Sorting and Genetic Engineering
HTW Berlin, Dept. Life Science Engineering, Berlin, Germany

Development of a high-throughput screen utilizing a microfluidic device and a linearly growing yeast strain to simultaneously test the influence of various drugs on the replicative lifespan of yeast.
Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
MRCT

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.
The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
Axxam

This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.
Enabling Epigenetics Studies from HTS to SAR : A Novel HTRF® Platform to Identify and Characterize Reader Domain Inhibitors
1Cisbio Bioassays Codolet, France | 2CRCM, CNRS UMR7258, INSERM U1068, AMU UM105, Institut Paoli-Calmettes, Marseille, France | 3AFMB, UMR7257, Univ. Aix Marseille-CNR

Discover a novel HTRF platform to identify and characterize the vast variety of epigenetic binding domain.

Application Notes
Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
Colony Picking - fully automated screening of fungi
Tecan Group Ltd.

Manual screening processes are very costly and time consuming. This ambitious project for high throughput screening (HTS) of cellulase-producing fungal strains demonstrates the high capacity and unique features of the Freedom EVO colony picking workstation. The picking of fungi is more complex than for typical bacterial colonies, and requires advanced selection criteria to be combined with complex pipetting and a tip movement that mimics the manual picking process.
3D cell culture: a realistic and reproducible collagen-based environment
Tecan Group

Researchers are increasingly turning to 3D cell culture techniques, due to the improved physiological relevance of the cellular environment. 3D cell cultures offer a more in vivo-like response to stimuli more closely resembling the behavior of animal models or the human body.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Efficient washing of magnetic beads
Tecan Group Ltd.

The use of magnetic beads as the solid phase in a multiplexed ELISA enables high throughput cytokine screening and offers several advantages over common ELISA assays with direct coupling of the analyte to the well-surface.
Determination of microbial cell viability
Tecan Group Ltd.

The BacTiter-Glo Microbial Cell Viability Assay is a luminescence-based assay for the determination of the viability of microbial cells, using quantification of ATP as an indicator of metabolically active, viable cells. The assay protocol comprises the addition of the BacTiter-Glo reagent directly to the sample, and subsequent measurement of luminescence; cell washing, removal of culture medium, and multiple pipetting steps are not required.
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