NIH Common Fund Researchers Uncover Structure of Important Target for Drug Design
Researchers have uncovered a potent class of small molecules that selectively turn on the S1P1 receptor.

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New Findings in Drug-Induced Receptor Activity
The discovery that drugs targeting a single GPCR can differentially modulate distinct subsets of the receptor signaling repertoire is a very important step in drug discovery.

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A Modified MS2 Bacteriophage Plaque Reduction Assay for the Rapid Screening of Antiviral Plant Extracts
The ability of the MS2 plaque reduction assay to detect antiviral activity in these known antiviral plant preparations indicates its suitability as an antiviral screening tool.

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Cyclofluidic Announces First Fully Automated Lead Discovery Experiment
Scientists used the company’s proprietary microfluidic system to design, make and screen potential drug molecules active against thrombin, a target associated with stroke.

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Hamilton Introduces Automated DNA Sample Enrichment Solution
System uses Roche 454 REM e liquid handling system to replace hours of manual work.

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Dundee Researchers Seek to Beat "Molecular Obesity"
Researchers from the University of Dundee have come up with a new innovative approach in the quest to reduce failure rates in the drug discovery process.

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OGT Releases New Whitepaper for Aiding Biomarker Discovery
The new document explores the need for biomarkers as indicators of disease, and discusses the vast potential of autoantibodies as markers of early disease development.

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Scripps Research Scientists Create Novel RNA Repair Technology
Discovery could aid search for Huntington’s, Spinocerebellar Ataxia, and Kennedy Disease treatments.

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Scientists Uncover Novel Mechanism of Glioblastoma Development
Researchers believe understanding molecular mechanisms can lead to new treatments. Work focuses on importance of post-transcriptional regulation.

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Ganetespib Synergizes with Taxanes in Multiple Non-small Cell Lung Cancer Models
Combination of ganetespib with microtubule stabilizers, docetaxel and paclitaxel, or destabilizers, vincristine, was shown to result in synergistic anticancer activity.

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OGT Signs Licensing Deal for Colorectal Cancer Biomarkers
OGT has entered into an exclusive licensing agreement with Inven2.

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Evotec and IR Pharma Establish Drug Discovery Alliance
Companies have entered into an exclusive strategic alliance to provide integrated drug discovery solutions to Pharmaceutical and Biotech companies in the field of Respiratory Diseases.

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BD Diagnostics Expands Portfolio with Automated Instrumentation Technologies
Company announced the expansion of its microbiology portfolio to include new automated instrumentation technologies that will enable the Company to offer innovative total lab automation solutions to hospitals and laboratories worldwide.

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Artel Grows Technical Services Team for Liquid Handling Quality Assurance
To support the expanded application of Artel technology and services.

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Ironwood Pharmaceuticals Prices Public Offering of Common Stock
Company announces the pricing of an underwritten public offering of 5,250,000 shares of its Class A common stock at a price of $15.09 per share to the public.

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Zalicus and Hydra Collaborate to Advance Novel Ion Channel Product Candidates for the Treatment of Pain
The goal of the collaboration is to advance ion channel drug candidates into clinical development for the treatment of pain.

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Stephen Zaniboni Joins Trovagene, Inc. as Chief Financial Officer
Mr. Zaniboni's experience includes raising more than $500 million through venture financing and IPO proceeds.

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Tecan and Artel Partner to Offer QC Kit
QC Kit - a fully integrated performance verification solution for Freedom EVO® workstations.

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Brooks Life Science Systems and The Scripps Research Institute Initiate Partnership
Partnership will be an exclusive licensing agreement to jointly complete the development of a microplate imaging system created by Scripps Research and to enable Brooks Life Science Systems to manufacture and commercialize this imaging system.

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PerkinElmer Expands Reagent Portfolio for Faster Identification of Epigenetic Drug Candidates
The company announced the launch of four new cellular assay kits to help identify and characterize possible drug candidates targeting epigenetic enzymes related to key disease states.

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A Simple, Robust Automated Multiplexed Cell-Based Assay Process for the Assessment of Mitochondrial Dysfunction and Cytotoxicity
Biotek Instruments

Recent studies have shown that an increasing number of drugs no longer on the market have negative effects on mitochondrial function in key organs such as the liver and heart. Therefore it is increasingly important to monitor the effects of lead compounds on mitochondrial function in relevant cell systems. The ability to incorporate a simple, rapid, multiplexed, predictive assay can make the detection of potential toxic effects easier to perform early on in the drug discovery process.

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An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators
BioTek Instruments

The Androgen Receptor (AR) is a member of the family of nuclear receptors responsive to steroid hormones. This poster aims to devise, validate and perform a preliminary automated HTS screening campaign to identify novel modulators of AR activity.

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Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments

Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.

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Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments

TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.

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Automation of a Generic Fluorescence Methyltransferase Activity Assay
BioTek Instruments

Epigenetic processes are attracting considerable attention in drug discovery as their fundamental roles in controlling normal cell development and contributions to disease states become more clearly defined. This work combines a fluorescence-based assay with liquid handling and dispensing instrumentation and a multi-mode reader which can be used to monitor the biological activity of the histone methyltransferase (HMT) G9a, a model system.

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Automation of a Novel Cell-Based ELISA for Cell Signaling Pathway Analysis
BioTek Instruments

Monitoring and quantifying cell signaling pathways is critical for understanding the behavior of cell processes and many disease states. Monitoring and quantifying cell signaling pathways is critical for understanding the behavior of cell processes and many disease states.

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Efficacy of Using a Combination Microplate Washer for Vacuum-Based DNA Sequencing Reaction Cleanup
BioTek Instruments

The ability to determine the specific pattern of base pairs in DNA molecules is an indispensable part of contemporary molecular biology. This poster demonstrates how the vacuum filtration module available on the BioTek 405 Touch effectively cleans contaminating artifacts from DNA sequencing reactions, which wil contribute to the genomic workflow typical of many molecular biology laboratories and core facilities.

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Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments

Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.

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Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences

Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.

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High Content Analysis of Neural Stem Cell Expansion and Differentiation
Molecular Devices

Automated assay methods for monitoring neural stem cell expansion and differentiation using stem cell derived neural cell lines and high content imaging systems have been described.

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Performance Qualification of an Automated Plate Washer Using the Artel MVS®
Artel

The purpose of this application note is to demonstrate the ability of the MVS® Multichannel Verification System to test the performance of an automated plate washer. The previously written application notes, Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach1 will be cited within as these unique applications relate to this discussion involving tests for (1) bulk dispense precision and accuracy and (2) volume evacuation efficiency.

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Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach
Artel

The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision for a volume transfer of sample into a microtiter plate, the MVS is instead used to measure resididual liquid after sample is aspirated out of each well.

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Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates
Artel

This application note describes how the ARTEL MVS® Multichannel Verification System can be used as a tool for measuring the efficacy of liquid mixing protocols.

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Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®
Artel

This study illustrates the use of the Artel MVS® Multichannel Verification System to rapidly evaluate the accuracy and precision of dispensed volumes from the Caliper RapidPlate liquid handler.

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Kv1.5 Potassium Channel Assay Using the IonWorks HT System
Molecular Devices

This application note describes the use of the IonWorks HT Platform with a voltagedependent potassium channel Kv1.5.

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Applications of rapid immunoassays (FAST ILA) in cell culture/fermentation and process development using the Threshold System
Molecular Devices

Accurate measurement of the concentration of a biological product is important in bioreactor/fermenter monitoring, downstream processing and final product quality control. Currently, electrophoretic, chromatographic and immunochemical methods are the most commonly used. These three methods are currently used in combination to provide the desired sample information.

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Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.

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Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.

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Recording of ICRAC in RBL-1 Cells on the PatchXpress 7000A Automated Patch Clamp System
Molecular Devices

Calcium release-activated calcium (CRAC) channels play an important role in intracellular Ca2+ homeostasis. Like other store-operated calcium channels, currents through the CRAC channel (ICRAC) are activated by depletion of calcium in the endoplasmic reticulum (ER) and serve the purpose of slowly replenishing the ER with Ca2+.

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Overcoming the Challenge of Reliable Multi-way Fluidic Connections
Dolomite

If you are struggling to create fast and reliable microfluidic connections, Multiflux™ may be the solution you are looking for.

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