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The Lipidyzer™ Platform: A Revolutionary...
From Sequencing to Interpretation: Bioin...What are the biggest challenges in drug ...DeNovix DS-11 FX Spectrophotometer / Flu...

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Featured Product - Automated Microplate Blowdown Evaporator
Automated Microplate Blowdown Evaporator
Featured Product - NutriStem® hPSC XF Medium A Superior Xeno-free, Serum-free Culture Medium for hES and hiPS Cells
NutriStem® hPSC XF Medium A Superior Xeno-free, Serum-free Culture Medium for hES and hiPS Cells

Webcasts
Webcast - The Tip of the Iceberg - How Pipette Tips Influence Assay ResultsThe Tip of the Iceberg - How Pipette Tips Influence Assay Results
n this webinar, you will learn everything you need to know about pipette tips and the huge impact they can have on your results.
Webcast - Do it with our UNcle... we mean protein characterizationDo it with our UNcle... we mean protein characterization
In this webinar we will demonstrate our streamlined software package, allowing you to quickly and easily assess your protein stability.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Advances in Ion Channel Drug Discovery
Business Insights

The report highlights the most promising areas for ion channel discovery enabled by technology and target validation advances. Channel families with major potential are discussed to highlight the most promising areas for investigation. New technologies and the companies exploiting these are identified. The relative prospects of programs in late-stage development are assessed.
Scientific News
Featured Article
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.

Featured Article
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.

Protein-Based “Cancer Signature” Uncovered
Researchers investigated the expression of ribosomal proteins in human tissues and discovered a cancer type specific signature which could be used to predict the progression of the disease.
Ribosome Recycling as a Drug Target
Researchers explain mechanism that recycles bacterial ribosomes stalled on messenger RNAs that lack termination codons.
Predicting Leukaemia Development in Cancer Patients
Biomarker may predict which formerly treated cancer patients will develop highly fatal form of leukemia.
Survey of New York City Soil Uncovers Medicine-Making Microbes
Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.
'Lab on the Skin' for Sweat Analysis
Northwestern University researchers develop a low-cost wearable electronic device that collects and analyzes sweat for health monitoring.
Toxoplasma’s Balancing Act Explained
Parasite’s method of rewiring our immune response leads to novel tool for drug tests.
Cancer Signaling Pathway Illuminating Way To Therapy
Researchers refine a pro-growth signalling pathway, common to cancers, that can kill cancer cells while leaving healthy cells unharmed.
Breast Cancer Cells Starve for Cystine
Depriving triple negative breast cancer, a treatment-resistant form of breast cancer, of cystine results in cancer cell death.
Business News
Singulex, Thermo Fisher Announces Agreement
Agreement to bring next generation immunodiagnostics to sepsis and SIRS diagnostics.
CGI, BeiGene Collaborate
Collaboration aims to provide target identification and biomarker discovery services to cancer drug developer BeiGene.
Evogen, UCB Announce Collaboration
The aim is to further the development of EvoScore START for the improved diagnosis of epilepsy.
Parker Institute, CRI Announces Collaboration on Cancer Neoantigens
This new collaboration, the Tumor neoantigEn SeLection Alliance, includes 30 of the world’s leading cancer neoantigen research groups from both academia and industry.
Improving the Speed and Cost-Efficiency of Drug Discovery
Optibrium and MolPort collaborate, combining MolPort’s 6.3 Million HTS Compounds with StarDrop’s data analysis and compound design capabilities.
NY State Approves CombiPGS™ NGS Test
The CombiPGS™ test is for women undergoing in vitro fertilization and screens embryo biopsy cells for chromosomal abnormalities prior to implantation of the embryo.
GTG, The University of Melbourne Collaborate
Collaboration aims to develop colorectal cancer risk assessment test.
Enamine, Pcovery Extend Drug Discovery Collaboration
Enamine and Pcovery extend their drug discovery collaboration, focused on the treatment of invasive fungal infections.
BMY, Enterome Collaborate
Collaboration aims to focus on microbiome-derived biomarkers, drug targets and bioactive molecules.
Seven Bridges' Platform Integration with SolveBio
Platform enables researchers to seamlessly transition from cloud-based genomic data analysis to clinical interpretation of results.

Events
Laboratory Data Integrity
12 Dec 2016
Laboratory Data Integrity ...
13th Winter Conference on Medi
22 Jan 2017
13th Winter Conference on Medi ...
2nd Good Laboratory Practice C
26 Jan 2017
2nd Good Laboratory Practice C ...
16th Annual Strategic Project
24 Jan 2017
16th Annual Strategic Project ...

ePosters
Functional Analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in Human Prostate Cell Lines
[sup}1.[/sup} The Institute of Cancer Research, 123 Old Brompton Road, London, UK 2.The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK

The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
GE Healthcare Dharmacon, Inc.

Chemical synthesis has been easily applied for rapidly generating either crRNA and tracrRNA or synthetic sgRNA for direct delivery into cells for gene editing applications such as DNA-free options and high throughput arrayed screening.
The Chemical Synthesis of Long and Highly Modified RNA using 2'-ACE Chemistry
GE Healthcare Dharmacon, Inc.

Dharmacon has previously developed a novel RNA synthesis chemistry making RNA synthesis as reliable, accessible and of comparable quality as routinely observed in DNA synthesis.
Experimental design considerations for efficient and specific gene knockin using a CRISPR-Cas9 for HDR with synthetic crRNA and tracrRNA
Dharmacon, part of GE Healthcare

Precise genome engineering with CRISPR-Cas9 and single-stranded DNA oligo or double-stranded DNA plasmid donors via homology-directed repair (HDR).
Exosomes promote survival in squamous head and neck cancer cells after ionizing radiation
Helmholtz Zentrum München, Institute of Radiation Biology, Neuherberg, Germany / Department of Chemistry, Technical University of Munich, Munich, Germany

Exosomes are important intercellular communicators in the acute radiation stress-response. These nanometer-sized extracellular vesicles confer protective signals to neighboring cells and therefore promote the tumorigenic and radioresistant phenotype of head and neck cancer cells.
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
Resistance-Associated Variants in HCV Genotype 1 Populations
1Vela Diagnostics Pte. Ltd., Singapore; 2Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore; 3Department of Patholo

In this study we specifically investigated RAVs emerging in HCV genotype 1.
Integrated Next-Generation Sequencing and qPCR Workflow in Clinical Diagnostics
Vela Diagnostics Pte. Ltd., Singapore

Combined automated qPCR and NGS Sentosa workflow is a reliable and efficient in vitro diagnostics (IVD) tool for the detection and/or quantitation of a wide range of bacterial and viral pathogens as well as gene mutations.
A Synthetic CRISPR-Cas9 System for Homology-directed Repair
Dharmacon (part of GE Healthcare)

Synthetic, dual-RNA-encoded Cas9 is used for precise homology-directed repair (HDR) gene engineering. Both short and long (GFP) inserts are covered.
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Dharmacon (part of GE Healthcare)

CRISPR-Cas9 gene editing using synthetic crRNA:tracrRNA or sgRNA is highly efficient and easy to use. Synthetic crRNA:tracrRNA is uniquely suited to in vitro and in vivo applications, in particular, DNA-free approach with Cas9 mRNA. Chemical synthesis of guide RNAs allows accurate and rapid production of arrayed crRNA libraries for high-confidence, loss-of-function screens.
Application Notes
Optimization of a Multi-Mode Detection Model for Measuring Real-time Cellular Respiration and Mitochondrial Function using Fluorophoric Biosensors
BioTek Instruments, Inc.

Cellular metabolism characterization is being aided by the development of new tools designed to provide ease-of-use, higher throughput, and multiplexed data markers for analysis.
A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research
SCIEX

The Lipidyzer™ Platform, powered by Metabolon®.
Novel Chemical Standards Kits Enable Facile Lipid Quantitation
SCIEX

The Lipidyzer platform provides more accurate lipid analysis with less quantitative bias.
Development of a Homogenous RSV Neutralisation Assay on the Mirrorball Fluorescence Cytometer
ttp labtech

Here we present the development and implementation of a simple RSV-neutralisation assay on TTP Labtech’s mirrorball fluorescence cytometer.
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors
Malvern Instruments Limited

Analysis of data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES)* indicated that an estimated 65 million individuals in the United States have hypertension.
Multiplex Genotyping of Human Reference DNA Samples with Pharmacologically Important Single Nucleotide Polymorphisms using the IntelliQube® from Douglas Scientific
Douglas Scientific

This study demonstrates the ability of the IntelliQube along with Array Tape®, to successfully achieve two multiplexed SNP genotyping results in a single well and decrease thermal cycling times without compromising data quality. The combination of achieving two results per reaction well and shortened cycling times dramatically increases overall throughput.
Cells in Double Emulsions for FACS Sorting
Dolomite

Capturing individual cells in 30 µm double emulsions,suitable for FACS sorting.
How Malvern Microcal ITC Adds Value In Drug Discovery With Applications From Assay Development To Lead Optimization
Malvern Instruments Limited


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