Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
Become a Member | Sign in
Home>News>This Article

Definiens Expands Functionality of its Leading Solution for Quantitative Digital Pathology

Published: Monday, October 22, 2012
Last Updated: Monday, October 22, 2012
Bookmark and Share
Definiens Tissue Studio now supports the detection of spot-like signals from in situ hybridization assays.

Definiens® has announced that Definiens Tissue Studio® 3.5 now supports the automated analysis of in situ hybridization assays, including SISH, CISH, FISH and dual-ISH.

The unique combination of flexibility and ease-of-use that characterizes Definiens Tissue Studio® significantly facilitates the detection of spot-like signals originating from gene probes (or any other stain with spot-like appearance) on a cell-by-cell basis.

Definiens Tissue Studio® supports the detection of gene probe signals in both brightfield and immunofluorescene imaging.

The novel functionality complements the robust detection of regions of interest and the comprehensive quantification of cellular parameters and biomarker expression profiles.

Definiens Tissue Studio® can be used to analyze images from any solid tissue with any stain, acquired by any scanner or microscope, and in any common file format.

With these technological advances, pathologists and researchers can adapt preconfigured solutions to their specific assays with just a few clicks in no more than 30 minutes.

Straightforward workflow, intuitive configuration, as well as flexibility and robustness, have established Definiens Tissue Studio as the leading image analysis solution for quantitative digital pathology.

Definiens Tissue Studio opens new dimensions in quantification by significantly reducing study times in translational research, preclinical safety, tissue-based biomarker development and clinical trials around the world.

The new version includes a range of improvements that make it easier to use and more powerful than ever.

“Definiens has developed significant experience in the analysis of in situ hybridization assays in recent years,” said Thomas Heydler, CEO of Definiens.

Heydler continued, “In Definiens Tissue Studio® 3.5, we now make this available to our customers in a very easy-to-use workflow that supports virtually any type of 2D ISH assay. This further strengthens Definiens Tissue Studio’s position as the most comprehensive software package for quantitative digital pathology.”

With just a single configuration, Definiens Tissue Studio® automates the detection of regions of interest and has the capacity to distinguish individual cells and subcellular structures even in heterogeneous tissues samples.

The software provides quantitative readouts on morphological characteristics and molecular expression profiles of nuclear, cytoplasmic and membrane biomarkers.

In addition, Definiens Tissue Studio® supports robust detection of vessels for automated angiogenesis assays as well as extensive multiplexing for the quantification of numerous parameters from the same tissue sample in immunofluorescence assays.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,700+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Definiens Image Analysis Technology Improves Accuracy in Scoring Her2/neu in Breast Cancer Biopsies
New multi-dimensional image analysis platform aids diagnosis and treatment of breast cancer.
Wednesday, June 03, 2009
Scientific News
Four New Genetic Disorders Identified
Sharing of genetic data empowers discovery of new disorders in children.
Biomarker Predicting Transplant Complications May be Key to Treating Them
A protein that can be used to predict if a stem cell transplant patient will suffer severe complications may also be the key to preventing those complications, an international research team based at the Indiana University School of Medicine reported Wednesday.
Potential New Diagnosis and Therapy for Breast Cancer
Scientists at the University of York, using clinical specimens from charity Breast Cancer Now’s Tissue Bank, have conducted new research into a specific sodium channel that indicates the presence of cancer cells and affects tumour growth rates.
Enzyme Malfunction May be Why Binge Drinking Can Lead to Alcoholism
A new study in mice shows that restoring the synthesis of a key brain chemical tied to inhibiting addictive behavior may help prevent alcohol cravings following binge drinking.
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
Promising Drug Candidate to Treat Chronic Itch
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) describe a class of compounds with the potential to stop chronic itch without the adverse side effects normally associated with medicating the condition.
Are Changes to Current Colorectal Cancer Screening Guidelines Required?
Editorial suggests more research is needed to pinpoint age to end aggressive screening.
Assessing Cancer Patient Survival and Drug Sensitivity
RNA editing events another way to investigate biomarkers and therapy targets.
New Molecular Marker for Killer Cells
Cell marker enables prognosis about the course of infections.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,700+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos