Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
Become a Member | Sign in
Home>News>This Article

Crown Bioscience, Inc. and Horizon Discovery, Ltd. to Showcase X-MAN Cell Lines

Published: Thursday, November 15, 2012
Last Updated: Thursday, November 15, 2012
Bookmark and Share
Companies will highlight the availability of X-MAN™ cell lines for in vitro and in vivo drug discovery model validation at the 24th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics.

High-quality human disease models are crucial for generating 'first-in-class' patient-relevant targets and facilitating the development of novel oncology targets and early-stage drug discovery programs within the pharmaceutical industry. The new in vivo X-MAN (X-Gene Mutant And Normal) models will be made available to customers by Crown Bioscience via a new service offering whilst Horizon will provide access to a broad range of in vitro services based around its inventory of; >450 X-MAN cell lines, >50 phenotypic cell-based assays and its SyntheTx™ drug/RNAi screening platform.

Leveraging their unique drug discovery and translational research platforms, Crown Bioscience and Horizon Discovery help develop the best drug candidates with high confidence for clinical development, reducing drug attrition and development cost. Crown Bioscience and Horizon Discovery are ideally placed to help bring to the clinic lead molecules based upon highly validated and novel drug models. The in vitro and in vivo cell lines are available to clients who want to help validate new models and become early adopters with full access to new models at the earliest possible phase.

“Crown Bioscience aspires to become the innovation engine for the global biotech and pharmaceutical industry. We are guided by our responsibility to clients and a desire to make a major positive impact on human life worldwide. We are constantly pioneering new paths and finding new answers to meet the urgent needs of our customers’ waging war against cancer,” said Jean-Pierre Wery, President of Crown Bioscience. “The novel in vivo models we are developing based on the X-MANTM cell lines offer new opportunities for clients to collaborate with us at an early stage and validate the models based on their needs, This will allow greater insights and better means to evaluate the therapeutic efficacy of compounds and their impact on key physiological functions.”

“Horizon Discovery uses its highly efficient and proprietary gene-engineering platform technology, GENESIS™ to precisely engineer X-MAN human disease models that harbor the key genetic features that drive a patient’s disease” commented Darrin Disley, CEO of Horizon Discovery. “We are delighted to provide Crown Bioscience with our unique range of X-MAN cell lines, so that Crown can develop and provide our clients with a suite of in vivo models that complements our extensive range of in vitro services.”

The new in vivo models demonstrate Crown Bioscience’s commitment to continuing to invest in and expand its portfolio of models and to work collaboratively with partners and clients to accurately and robustly evaluate the efficacy of new therapeutic agents. The in vivo models are designed to help clients address their key needs and challenges by providing cutting-edge clinically relevant models that are ready to run. Crown Bioscience’s comprehensive services for drug development, from target to pre-IND, have accelerated confident Go/No Go decisions during early stage drug discovery and ensured robust pre-clinical candidate selection.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Potential Persistent Tuberculosis Treatment
Researchers have discovered several first-in-class compounds that target hidden TB infections by attacking a critical process the bacteria use to survive in the hostile environment of the lungs.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
The Do’s and Don’ts of SPR Experiments
Surface Plasmon Resonance (SPR) is a technique that is becoming more widely used, particularly by anyone who wants to obtain accurate on (association) and off (dissociation) rates for biomolecular binding.
Long-Sought Protein Sensor for the ‘Sixth Sense’ Discovered
In a study led by scientists from The Scripps Research Institute (TSRI)the sensor protein for propioception has been identified.
New Anti-Malarial Drug Screening Model
University of South Florida researchers demonstrate novel chemogenomic profiling to identify drug targets for the most lethal strain of malaria.
Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos