Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Crown Bioscience, Inc. and Horizon Discovery, Ltd. to Showcase X-MAN Cell Lines

Published: Thursday, November 15, 2012
Last Updated: Thursday, November 15, 2012
Bookmark and Share
Companies will highlight the availability of X-MAN™ cell lines for in vitro and in vivo drug discovery model validation at the 24th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics.

High-quality human disease models are crucial for generating 'first-in-class' patient-relevant targets and facilitating the development of novel oncology targets and early-stage drug discovery programs within the pharmaceutical industry. The new in vivo X-MAN (X-Gene Mutant And Normal) models will be made available to customers by Crown Bioscience via a new service offering whilst Horizon will provide access to a broad range of in vitro services based around its inventory of; >450 X-MAN cell lines, >50 phenotypic cell-based assays and its SyntheTx™ drug/RNAi screening platform.

Leveraging their unique drug discovery and translational research platforms, Crown Bioscience and Horizon Discovery help develop the best drug candidates with high confidence for clinical development, reducing drug attrition and development cost. Crown Bioscience and Horizon Discovery are ideally placed to help bring to the clinic lead molecules based upon highly validated and novel drug models. The in vitro and in vivo cell lines are available to clients who want to help validate new models and become early adopters with full access to new models at the earliest possible phase.

“Crown Bioscience aspires to become the innovation engine for the global biotech and pharmaceutical industry. We are guided by our responsibility to clients and a desire to make a major positive impact on human life worldwide. We are constantly pioneering new paths and finding new answers to meet the urgent needs of our customers’ waging war against cancer,” said Jean-Pierre Wery, President of Crown Bioscience. “The novel in vivo models we are developing based on the X-MANTM cell lines offer new opportunities for clients to collaborate with us at an early stage and validate the models based on their needs, This will allow greater insights and better means to evaluate the therapeutic efficacy of compounds and their impact on key physiological functions.”

“Horizon Discovery uses its highly efficient and proprietary gene-engineering platform technology, GENESIS™ to precisely engineer X-MAN human disease models that harbor the key genetic features that drive a patient’s disease” commented Darrin Disley, CEO of Horizon Discovery. “We are delighted to provide Crown Bioscience with our unique range of X-MAN cell lines, so that Crown can develop and provide our clients with a suite of in vivo models that complements our extensive range of in vitro services.”

The new in vivo models demonstrate Crown Bioscience’s commitment to continuing to invest in and expand its portfolio of models and to work collaboratively with partners and clients to accurately and robustly evaluate the efficacy of new therapeutic agents. The in vivo models are designed to help clients address their key needs and challenges by providing cutting-edge clinically relevant models that are ready to run. Crown Bioscience’s comprehensive services for drug development, from target to pre-IND, have accelerated confident Go/No Go decisions during early stage drug discovery and ensured robust pre-clinical candidate selection.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
Insights into the Function of the Main Class of Drug Targets
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.
Visualizing a Cancer Drug Target at Atomic Resolution
Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.
Honey’s Potential to Save Lives
The healing powers of honey have been known for thousands of years.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Cytoskeleton Crew
Findings confirm sugar's role in helping cancers survive by changing cellular architecture.
Biomarker for Recurring HPV-Linked Oropharyngeal Cancers
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
Valvena, GSK Sign New R&D Collaboration
Valneva to supply process development services for EB66® -based Influenza vaccines.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!