Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scanning Innovation can Improve Personalized Medicine

Published: Wednesday, November 28, 2012
Last Updated: Wednesday, November 28, 2012
Bookmark and Share
New combinations of medical imaging technologies hold promise for improved early disease screening, cancer staging, therapeutic assessment, and other aspects of personalized medicine.

The following research by Ge Wang, director of Virginia Tech's Center for Biomedical Imaging is documented in a recent paper that appeared in the refereed journal PLoS One.

The integration of multiple major tomographic scanners into a single framework "is a new way of thinking in the biomedical imaging world" and is evolving into a "grand fusion" of many imaging modalities known as "omni-tomography," explained Wang, the lead author of the article.

Wang has a history of "firsts" in the imaging world, including the first paper on spiral multi-slice/cone-beam (computed tomography) CT in 1991, on bioluminescence tomography in 2004, and on interior tomography in 2007.

"The holy grail of biomedical imaging is an integrated system capable of producing tomographic, simultaneous, dynamic observations of highly complex biological phenomena in vivo," Wang said.

Currently, dual-modality imaging such as a positron emission tomography and magnetic resonance imaging (PET/MRI) is "a powerful example of the synergy provided" by using the two as a hybrid technology when assessing concerns in oncology and cardiology, Wang said. "There are no longer any lone PET scanners. Today all are coupled with computed tomography scanners," added Wang.

For the past decade, Wang and his colleagues have investigated approaches to fusing the various scanning techniques. Recently, they became interested in going beyond the dual-mode imaging, and found that the enabling technology for omni-tomography is "interior tomography" that allows for the integration of multiple major tomographic scanners into one architecture.

He explained that many of the real-world problems in cancer or heart disease are localized or often observed in a relatively small region of interest (ROI) in a human body. In order to obtain a theoretically exact reconstruction of this small area, Wang and others have shown that by using some prior knowledge and common properties on an ROI, they can precisely reconstruct the ROI from data collected with a narrow X-ray beam just covering the ROI.

"We call this novel approach `interior tomography'," Wang added. "In our latest work, we elevated interior tomography from its origin in X-ray CT to a general tomographic imaging principle, and demonstrated its validity for different tomographic modalities including single-photon emission computed tomography (SPECT), MRI, and phase-contrast tomography," Wang said.

Because interior tomographic imaging can be theoretically exact and practically informative for each of all the major imaging modalities, it becomes feasible to make each scanner "slimmer" or more compact. This compression creates the necessary room to put all of the involved tomographic modalities tightly together in space, and operates them in parallel, achieving space and time synchrony. "It is necessary to depict complicated correlative relationships among diversified physiological features," Wang further explained.

The potential clinical applications for omni-tomography may improve personalized medicine. "As an example enabled by interior tomography, an interior CT-MRI scanner can target the fast-beating heart for registration of functions and structures, delivery of drugs or stem cells, and guidance of complicated procedures such as heart valve replacement," Wang said.

Omni-tomography as a unified technology "also gives leverage to a greatly reduced radiation dose when MRI-aided interior CT reconstruction is implemented," Wang asserted. On the other hand, "it can generate higher-resolution details in MRI images."

The reduction in radiation dosage is a hot topic in the CT field.  Medical X-rays, in use for more than 100 years, only accounted for about 10 percent of the total American radiation exposure in the late 1980s. The subsequent growth of the use of various medical X-ray imaging methods now accounts for approximately half of the total radiation exposure of the U.S. population.

"Omni-tomography is a promising direction for biomedical imaging and systems biomedicine," Wang said. Wang's team efforts are related to the Physiome Project, a worldwide undertaking to understand an individual's physiological state from the genome scale to complex organisms in a systematic fashion. This project supports a worldwide repository of models and data sets and is an integral part of systems medicine. "Biomedical imaging is instrumental for the Physiome Project, and especially so could be omni-tomography," Wang added.

This work was funded partially by the National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering grant EBO11785 and National Institutes of Health/National Heart, Lung, and Blood Institute grant HLO98912.

The co-authors of the paper who are affiliated with the Virginia Tech -- Wake Forest University School of Biomedical Engineering and Sciences include: Hengyong Yu, Wenxiang Cong, Haiou Shen, James Bennett, Mark Furth, and Yue Wang.

The other collaborators include: Jie Zhang of the University of Kentucky, Hao Gao of the University of California Los Angeles, Victor Weir of the Baylor Health Care System, Xiaochen Xu of Texas Instruments Inc., and Michael Vannier of the University of Chicago.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Psychiatric Disorders Linked to a Protein Involved in the Formation of Long-Term Memories
Researchers have discovered a pathway by which the brain controls a molecule critical to forming long-term memories and connected with bipolar disorder and schizophrenia.
Tuesday, June 25, 2013
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Protein Related to Long Term Traumatic Brain Injury Complications Discovered
NIH-study shows protein found at higher levels in military members who have suffered multiple TBIs.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
Crystal Clear Images Uncover Secrets of Hormone Receptors
NIH researchers gain better understanding of how neuropeptide hormones trigger chemical reactions in cells.
New Tool Uses 'Drug Spillover' to Match Cancer Patients with Treatments
Researchers have developed a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best "kinase inhibitor" to silence these dangerous genetic causes of disease.
HIV Susceptibility Linked to Little-Understood Immune Cell Class
High levels of diversity among immune cells called natural killer cells may strongly predispose people to infection by HIV, and may be driven by prior viral exposures, according to a new study.
Sweet Revenge Against Superbugs
A special type of synthetic sugar could be the latest weapon in the fight against superbugs.
Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support
A new study reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!