Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
Become a Member | Sign in
Home>News>This Article

Gentronix Awarded Grant of £147,552 by MRC and Technology Strategy Board

Published: Thursday, December 20, 2012
Last Updated: Thursday, December 20, 2012
Bookmark and Share
Company awarded grant from the Biomedical Catalyst programme for an epigenetic based screening assay feasibility study.

Gentronix Ltd., Manchester UK, has been awarded a grant of £147,552 by the Medical Research Council (MRC) and the Technology Strategy Board under the joint £180 million Biomedical Catalyst programme.

The project funded by the award will look at the feasibility of developing a screening assay for compounds that may cause cancer as a result of epigenetic mechanisms.

Before being approved for use, chemicals such as pharmaceuticals, agrochemicals and consumer products have to be tested for genetic toxicity i.e. their potential to change the DNA sequence or the number of chromosomes in a cell.

Exposure to genotoxic chemicals can lead to the development of cancers. They can be identified by routine screening tests used by laboratories such as Gentronix.

There are also non-genotoxic carcinogens that alter patterns of gene expression without changing the number or sequence of chromosomes.

There are currently no widely used screening tests available for these and they might only be identified in later animal exposure studies, which are time consuming, costly and come quite late in product development - an expensive time to fail.

Epigenetics is a relatively new field, concerned with the regulation of genes by chromosome modifications which don’t change the DNA sequence or chromosome numbers.

Epigenetic changes can also lead to the development of cancers and it is this aspect of early toxicology screening that the team at Gentronix Ltd., led by Chief Scientist, Prof. Richard Walmsley will be looking to address under the award.

Gentronix CEO, John Nicholson said “Gentronix has an excellent track record of innovation, and though as a growing company we have to balance innovative research with customer priorities, the award of this grant gives us the opportunity to carry out important fundamental research; the results of which will allow us to make informed decisions about the commercial potential of an epigenetics-based assay as well as making a contribution to the science of genetics”.

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,100+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Improved In Vitro Genotoxicity Testing to Reduce Animal Testing
In conjunction with the University of Manchester, Gentronix has been granted a research award of £133,024.
Thursday, August 10, 2006
Gentronix Secures R&D Award
The two-year grant will provide Gentronix with two scientists, cell culture facilities, and supporting laboratory instrumentation at its Manchester Incubator Core Technology Facility premises.
Tuesday, April 11, 2006
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
Targeting Cannabinoid CB2 Receptors in the CNS
With endogenous cannabinoids considered as a potential target to combat CNS diseases, this article examines the role of CB2R could play in fighting some disorders.
Bacterial Genes Boost Current in Human Cells
Borrowing and tweaking bacterial genes to enhance electrical activity might treat heart, nervous system injury.
Less Frequent Cervical Cancer Screening
HPV-vaccinated women may only need one screening every 5 to 10 years with screening starting later in life.
Cocoa Compound Linked to Some Cardiovascular Biomarker Improvements
The study highlights the urgent need for large, long-term RCTs that improve understanding of how the short-term benefits of cocoa flavanol intake on cardiometabolic biomarkers may be translated into clinical outcomes.
Untangling a Cause of Memory Loss in Neurodegenerative Diseases
The mouse study identifies a possible therapeutic target for a family of disorders.
New Pathway for COPD Biomarker Development
A study from Philip Morris International has highlighted multi-lipid profiling as a potential new pathway for COPD biomarker development.
Stiffening a Blow to Cancer Cells
Researchers develop a way to predict how a tumor tissue's physical properties affect its response to chemotherapy drugs.
Anti-Cancer Drug Uses Tumour mRNA to Identify Responders
Phase I study of novel anti-cancer drug uses tumour mRNA expression to identify patients who will respond to the drug.
New Strategy for Choosing Cancer Drugs
Device can predict tumor responses by measuring cell growth after drug exposure.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,100+ scientific videos