Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Health Risks from Arsenic in Rice Exposed

Published: Wednesday, July 24, 2013
Last Updated: Wednesday, July 24, 2013
Bookmark and Share
High levels of arsenic in rice have been shown to be associated with elevated genetic damage in humans, a new study has found.

Over the last few years, researchers have reported high concentrations of arsenic in several rice-growing regions around the world.

Now, University of Manchester scientists, working in collaboration with scientists at CSIR-Indian Institute of Chemical Biology in Kolkata, have proven a link between rice containing high levels of arsenic and chromosomal damage, as measured by micronuclei* in urothelial cells, in humans consuming rice as a staple.

The researchers discovered that people in rural West Bengal eating rice as a staple with greater than 0.2 mg/kg arsenic showed higher frequencies of micronuclei than those consuming rice with less than this concentration of arsenic.

The study, published in Nature Publishing Group’s Scientific Reports, looked at the frequency of ‘micronuclei’ – a tell-tale sign of chromosomal damage  (that has been shown by others previously to be linked to cancer) – by screening more than 400,000 individual cells extracted from urine samples from volunteers.

The team, funded by the UK India Education and Research Initiative (UKIERI), chose a study population with relatively similar dietary and socio-economic status that was not otherwise exposed to arsenic, for example, through drinking water.

They demonstrated that the trend of greater genetic damage with increasing arsenic in rice was observed for both men and women, for tobacco-users and non-users, and for those from three different locations within the study area. The pattern observed was broadly similar to that previously seen for people exposed to arsenic through drinking high arsenic well waters, which has caused devastating health impacts, including cancers, in many parts of the world.

The authors say their work raises considerable concerns about health impacts of consuming high arsenic rice as a staple, particularly by people with relatively poor nutritional status – perhaps as many as a few hundred million people. How directly relevant the results are to people in the UK, with a generally lower consumption of rice and better nutritional status, remains to be fully determined but is an obvious focus for further research.

Professor David Polya, who led the Manchester team in the University’s School of Earth, Atmospheric and Environmental Sciences, said: “Although concerns about arsenic in rice have been raised for some time now, to our knowledge, this is the first time a link between consumption of arsenic-bearing rice and genetic damage has been demonstrated. As such, it vindicates increasing concerns expressed by the European Food Safety Authority and others about the adequacy of regulation of arsenic in rice.

“In the absence of contamination, rice is an easily stored food that provides essential energy, vitamins and fibre to billions of people around the world, but a small proportion of rice contains arsenic at concentrations at which we have observed significant genetic damage in people who consume it as a staple food. We hope that our work will encourage efforts to introduce regulatory standards for arsenic in food, and particularly in rice, which are more consistent and protective of human health.”

Dr Ashok K Giri, who led the Indian research team, added: “Although high arsenic in rice is a potential threat to human health, there should not be any panic about the consequences, particularly as the health risks arise from long-term chronic exposure. We can avoid high arsenic rice by taking proper mitigation strategies for rice cultivation; moreover, one CSIR institute in India has already identified a number of Indian rice varieties which accumulate lower concentrations of arsenic, so we can easily address future human health risks with proper mitigation strategies Results of this study will not only help to understand the toxic effects caused by this human carcinogen but also these results will help the scientists and regulatory authorities to design further extensive research to set improved regulatory values for arsenic in rice, particularly for those billions of people who consume 10 to 50% rice in their daily diet.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Honey’s Potential to Save Lives
The healing powers of honey have been known for thousands of years.
Wednesday, February 10, 2016
Molecular Clues to Serious Illnesses to be Explored
The University of Manchester is to lead a new £2.9 million molecular pathology research project to improve diagnosis and treatment of non-cancerous diseases within the NHS.
Friday, July 31, 2015
Scientific News
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
Insights into the Function of the Main Class of Drug Targets
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.
Visualizing a Cancer Drug Target at Atomic Resolution
Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.
Honey’s Potential to Save Lives
The healing powers of honey have been known for thousands of years.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Cytoskeleton Crew
Findings confirm sugar's role in helping cancers survive by changing cellular architecture.
Biomarker for Recurring HPV-Linked Oropharyngeal Cancers
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
Valvena, GSK Sign New R&D Collaboration
Valneva to supply process development services for EB66® -based Influenza vaccines.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!