Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Berthold Launches Mithras2 Multi-Technology Microplate Reader

Published: Friday, September 27, 2013
Last Updated: Friday, September 27, 2013
Bookmark and Share
Mithras2 LB943 with monochromator and filter technology.

Berthold Technologies has introduced the second generation of its Multimode Microplate Reader Mithras, the Mithras2 LB943 with monochromator and filter technology for these reading technologies
• UV/VIS Absorbance
• Fluorescence and FRET
• Fluorescence Polarization
• Time-Resolved Fluorescence (TRF and TR-FRET)
• Luminescence
• BRET and BRET²
• AlphaScreen® and AlphaLISA®

Already implemented in the TriStar² the patent-pending optical concept ONE-4-ALL is employed for sensitive luminescence, fluorescence and absorbance measurements - with performances as in dedicated instruments - in the Mithras² for filter-based reading.

Additionally the instrument is equipped with two double monochromators with high blocking efficiency and high f-number (increased transmission) for filter-less measurements of absorbance and fluorescence.

For utmost sensitivity in luminescence a third specially selected and extremely noise-reduced detector is engaged in the HiSens position which is used for Alpha and BRET readings, too.

Compared to its predecessor the optics has been improved once again to achieve improved detection limits
• Less than 2 amol ATP per well
• Less than 0.2 fmol Fluorescein per well
• Less than 2 amol Europium per well

Mithras² offers the possibility to use optical filters for luminescence measurements (of course, for all fluorescence and absorbance readings, too) enabling the sensitive measurement of BRET (e.g. functional assays in GPCR research) and multi-coloured luciferases (reporter gene assays).

Each individual filter is coded with an RFID tag and can be positively identified - a significant contribution to correct measurements and to secure quality standards.

Up to 4 reagent injectors with the proven and highly accurate JET technology complete the unit. The injector tips are located in reading position enabling the accurate measurement of very fast reactions.

A new feature is the reagent compartment at the front which keeps the reagents within easy reach and which can be filled with ice to keep them cooled. Reagent mounts hold small reagent containers safely in place and a slight inclination of the mount ensures tubings recover the last droplet.

Cellular assays are taken account of by a universal bottom reading function, a temperature control unit with an incubation compartment for the microplate and gas connectors.

Thus, the Mithras2 is a microplate reader offering comprehensive possibilities and a multitude of applications. The measurement of enzyme activities, phagocytosis, calcium flux, cell viability, apoptosis, immunoassays protein and nucleic acid concentrations and protein-protein interactions are only a few of the manifold fields of application the instrument offers.

The unit is operated with the approved Mikrowin software. Single and multiple endpoint measurements can be performed as well as kinetic and scanning measurements. The data can be displayed numerically and graphically and may be exported to EXCEL or printed.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
It’s Now Easier To Go With The Flow
Rice University tool simplifies comparison of flow cytometry data for laboratories.
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
Drugs that May Combat Deadly Antibiotic-Resistant Bacteria Uncovered
Study identifies 79 compounds that inhibit carbapenem-resistant Enterobacteriaceae (CRE).
Making Precision Medicine a Reality
Researchers are one step closer to understanding the genetic and biological basis of diseases like cancer, diabetes, Alzheimer’s and rheumatoid arthritis – and identifying new drug targets and therapies.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment
Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Soy Shows Promise as Natural Anti-Microbial Agent
Soy isoflavones and peptides may inhibit the growth of microbial pathogens that cause food-borne illnesses, according to a new study from University of Guelph researchers.
Doubling Down on Dengue
HMS researchers have discovered two ways a compound blocks dengue virus.
Soy Shows Promise as Natural Anti-Microbial Agent
Researchers from University of Guelph show that soy isoflavones and peptides could be used to reduce microbial contamination of food.
AstraZeneca to Sequence 2 Million Genomes in Search for New Drugs
Company launches integrated genomics approach which aims to transform drug discovery and development.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!