Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Promega ADCC Reporter Bioassay Named to The Scientist Top 10 Innovations for 2013

Published: Wednesday, December 04, 2013
Last Updated: Wednesday, December 04, 2013
Bookmark and Share
Frozen, thaw-and-use cells greatly reduce assay variability.

Promega Corporation is pleased to announce that The Scientist has named the ADCC Reporter Bioassay to its 2013 Top 10 Innovations. The ADCC Reporter Bioassay is a surrogate assay for evaluating antibody-dependent, cell-mediated cytotoxicity (ADCC) of therapeutic mAbs, and it exhibits greatly reduced variability and is easier to perform than classic ADCC assays. ADCC is the primary mechanism of action of many mAb therapeutic drugs.

This innovation is transforming biologics drug development by allowing the biotech industry to more easily and reproducibly characterize mAb therapeutic drugs during manufacturing and lot release, as well as in earlier drug development stages such as clonal selection of antibodies.

The new ADCC Reporter Bioassay is available in kits with cells provided in frozen, thaw-and-use format, plus components to perform a homogeneous bioassay in a single day. The product replaces variable natural killer effector cells, typically primary in origin, with engineered effector cells that use a reporter gene readout approach. The effector cells, and control target cells, are ready to use without need for cell culture propagation.

The assay possesses all of the hallmarks of an optimal bioassay - excellent linearity, specificity, repeatability, precision and accuracy - and therefore can be used for potency lot release, stability indicating and antibody screening applications. Furthermore, the bioassay is sensitive enough to assess the impact of post-translational modifications, such as glycosylation and fucosylation, an area of intense exploration, on the potency of mAbs.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Gene Terapy for Muscle Wasting Developed
New gene therapy could save millions of people suffering from muscle wasting disease.
Detecting Alzheimer's with Smell Test
Odour identification test may offer low-cost alternative for predicting cognitive decline and detecting early-stage Alzheimer’s disease.
Fighting Cancer Through Protein Pathways
Researchers have found a new drug target within a protein production pathway critical to regulating growth and proliferation of cells.
Mutations in DNA-Repair Genes Found in Advanced Prostate Cancers
New findings indicate that nearly 12% of male advanced prostate cancer sufferers have inherited mutation in DNA-repair genes.
Molecule May Affect Gaucher, Parkinson's Disease
Research has identified a molecule that restores activity of a dysfunctional enzyme linked to Gaucher and Parkinson's disease.
Targeting BRAF Mutations in Thyroid Cancer
Treating metastatic thyroid cancer patients harboring a BRAF mutation with vemurafenib showed anti-tumor activity in a third of patients.
Plant Compounds Fight Together Against Colon Cancer
Research shows treating colon cancer cells with curcumin, then silymarin is more effective than treatment with each individually.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!