Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

ClinMet Metabolomics Platform Offers Unique Insights into Diabetic Kidney Disease

Published: Friday, December 13, 2013
Last Updated: Friday, December 13, 2013
Bookmark and Share
Findings overturn previous belief regarding relationship of mitochondrial activity and diabetic complications.

Researchers from The University of California, San Diego School of Medicine have published new metabolomics research that uncovers a novel, characteristic and highly consistent biochemical signature in urine associated with diabetic kidney disease. The findings, which form a foundation of ClinMet’s proprietary Clinical Metabolomics platform, have implications for the identification of clinically useful biomarkers for kidney function and for sharpening drug development and clinical trials related to chronic kidney disease, as well as to diabetes, obesity and cardiovascular disease.

The new research, authored by U.C. San Diego professor and ClinMet scientific founder, Kumar Sharma, M.D., F.A.H.A (Director of the Center for Renal Translational Medicine, Division of Nephrology-Hypertension and the Institute of Metabolomic Medicine) and colleagues, appears online in the Journal of the American Society of Nephrology. ClinMet has an exclusive license to use this set of metabolites in drug development and other applications, based on patents filed by UC San Diego.

The researchers quantified 94 urine metabolites in subjects with diabetes (type 1 or type 2) and chronic kidney disease (CKD), subjects with diabetes but no kidney disease, and healthy controls. They found that 13 of the metabolites were significantly different in those with disease compared to healthy controls (p values between 10-3 to 10-18), and 12 of 13 remained highly significant when compared to patients with type 1 or type 2 diabetes and no CKD. Moreover, 12 of the 13 metabolites were linked to mitochondrial metabolism and suggested global suppression of mitochondrial activity in the subjects with CKD relative to healthy individuals. This conclusion is in sharp contrast to prevailing beliefs about excess mitochondrial activity having a causal relationship to diabetic complications. The conclusions based on the urine metabolomic studies were independently validated based on protein and DNA analysis, indicating reduced mitochondrial content in the kidneys of patients with diabetic kidney disease.

“It is clear from this study that urine- and plasma-based metabolomics can be a rich source of biomarkers for understanding and treating diabetic kidney disease and possibly for related cardiovascular complications,” said Dr. Sharma. “This approach also offers direct insights into biochemical pathways linked to kidney dysfunction.”

Power of Clinical Metabolomics
“Genomics can help predict overall disease risk or a patient’s potential response to a drug, but cannot capture the effects that changes in diet, environmental factors, or other illnesses have on disease progression or improvement,” said Yesh Subramanian, President, Chief Executive Officer and co-founder of ClinMet. “Clinical metabolomics, in contrast, lets us quickly see biochemically what is happening in specific disease pathways over time and in the context of other factors affecting a patient’s health, including drug therapy. This makes clinical metabolomics a highly actionable platform for translational research and drug development.”

“We see clinical metabolomics enabling our pharmaceutical and biotech customers to effectively implement precision medicine today,” Mr. Subramanian noted. “The ability to predict which patients are likely to better respond to specific treatments holds immense promise for sharpening Phase 2 and 3 clinical trials now, and for improving clinical medicine in the future.” 


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Promising Class of New Cancer Drugs Cause Memory Loss in Mice
New findings from The Rockefeller University suggest that the original version of BET inhibitors causes molecular changes in mouse neurons, and can lead to memory loss in mice that receive it.
Electrical Control of Cancer Cells
Research led by scientists at The University of Texas Health Science Center at Houston (UTHealth) has revealed a new electrical mechanism that can control these switches.
Signature of Microbiomes Linked to Schizophrenia
Studying microbiomes in throat may help identify causes and treatments of brain disorder.
Inflammation Linked to Colon Cancer Metastasis
A new Arizona State University research study led by Biodesign Institute executive director Raymond DuBois has identified for the first time the details of how inflammation triggers colon cancer cells to spread to other organs, or metastasize.
Structural Discoveries Could Aid in Better Drug Design
Scientists have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.
Determining the Age of Fingerprints
Watch the imprint of a tire track in soft mud, and it will slowly blur, the ridges of the pattern gradually flowing into the valleys. Researchers have tested the theory that a similar effect could be used to give forensic scientists a way to date fingerprints.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
Researchers Publish Landmark “Basket Study”
Researchers from Memorial Sloan Kettering Cancer Center (MSK) have announced results from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients’ tumors rather than where their cancer originated.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!