Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

European Lead Factory - A Major New Drug Discovery Initiative

Published: Monday, January 27, 2014
Last Updated: Monday, January 27, 2014
Bookmark and Share
The European Lead Factory is the first of its kind and will provide a novel platform for innovative drug discovery.

Titian Software announces that its Mosaic software is to play a central role in compound library screening for a major new European drug discovery initiative, the European Lead Factory (ELF).  Following a successful bid to the Innovative Medicines Initiative (IMI), over 8.7m euros has been invested by BioCity Scotland (BCS) to establish a compound management facility at Newhouse Scotland, and selected Titian’s Mosaic sample management software for streamlining compound operations.   

BioCity Scotland has created a life sciences hub at Newhouse Scotland in the former Organon/Shering Plough/MSD site close to the busy M8 corridor, which offers highly equipped chemistry laboratories to small and medium sized businesses along with offices and other business premises for hire.  A major part of this centre is the revived compound management centre, in which the Mosaic software had previously been deployed. 

BioCity Scotland was founded in 2012 and is owned 75% by BioCity Nottingham Ltd and 25% owned by Roslin Biocentre Ltd. It operates the former Merck Sharp & Dohme (MSD) research facilities at Newhouse. It acquired the Automated Compound Store (ACS) and recruited highly skilled scientists and technicians who built and managed the facility since it was first established by Organon Laboratories in 2006.  The site has been re-commissioned to provide the ACS facilities for the European Lead Factory. BCS is the centre of excellence for the compound management activities and is responsible for the collection, storage, distribution, HTS logistics and tracking of the EU Lead Factory Compound Collection.

The European Lead Factory is a novel platform for innovative drug discovery and is owned by a 30 partner consortium, the first of its kind. With the support of the IMI, it creates unprecedented opportunities for the discovery of new medicines by providing public partners with an industry like discovery platform to translate cutting edge academic research into high quality drug lead molecules on a scale and speed that was not possible previously.

Pharmaceutical companies have vast libraries of compounds which can be screened in the hunt for potential medicines. But usually, access to these compound libraries is highly restricted.  As part of the European Lead Factory, the 7 participating pharmaceutical companies will contribute at least 300,000 chemical compounds from their corporate chemical collections. A library of an estimated additional 200,000 novel compounds will be developed jointly by academia and SMEs. Together the two libraries will form a Joint European Collection consisting of up to half a million compounds that will be accessible to all project partners and to public organisations offering promising new targets for drug discovery screening. 

With Mosaic’s proven performance and efficiency, BioCity has chosen Titians Mosaic software to ensure the high performance of its compound management operations for the ELF. 

Dr Sylviane Boucharens, director of Discovery Operations says: ”We are excited to have been selected to provide Compound Management for the ELF consortium as part of the new IMI project. This is a great opportunity to get the most out our facility  the former Organon/Schering-Plough/MSD research site) at  Newhouse and its highly-skilled team of scientists who are the former MSD staff who have demonstrated vision and drive in reviving the automated compound store.

We selected Titian’s Mosaic Compound Management software as part of this process and have found it to be an effective and efficient solution. We look forward to working with Titian moving forward, and have no doubt that will enhance our ability to deliver positive outcomes throughout the course of this project.“

Titian CEO Edmund Wilson said: “We are delighted to see the revival of the extensive automated storage facility at Newhouse. That BioCity Scotland has chosen to re-implement Mosaic as its sample management system, reflects its success and reputation in the management of extensive and highly valuable compound libraries, and we are excited that Mosaic will play such an important role in this new chapter of European drug discovery.”

The go-to solution for automated sample management within the pharmaceutical and biotech industries, Titian’s Mosaic software suite provides optimised storage, tracking and ordering of a range of samples including small molecule compounds.  The highly flexible and modular software can be easily tailored for site specific workflows.  Integration with third party IT systems, existing infrastructure and an extensive range of automated instrumentation is also enabled, streamlining the workflow.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Titian Software launches Mosaic 4.0
Proven sample management software now encompasses biological samples and reagents
Friday, April 23, 2010
Scientific News
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Penn State, TB Alliance, and GSK Partner To Discover New Treatments For TB
A new collaboration between TB Alliance, GSK, and scientists in the Eberly College of Science seeks to find new small molecules that can be used to create antibiotics in the fight against tuberculosis (TB).
Molecular Map Provides Clues To Zinc-Related Diseases
Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases.
Platelets are the Pathfinders for Leukocyte Extravasation During Inflammation
Findings from the study could help in the prevention and treatment of inflammatory pathologies.
Genetic Research Can Significantly Improve Drug Development
With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?
New Method Opens Door to Development of Many New Medicines
Findings from TSRI reveal human proteins are better drug targets than previously thought.
Diagnosing Systemic Infections Quickly, Reliably
Team develop rapid and specific diagnostic assay that could help physicians decide within an hour whether a patient has a systemic infection and should be hospitalized for aggressive intervention therapy.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Blood Test That Detects Early Alzheimer’s Disease
A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease – referred to as the mild cognitive impairment (MCI) stage – with unparalleled accuracy.
A New Approach to Chemical Synthesis
Communesins, originally found in fungus, could hold potential as cancer drugs.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!