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Measure Cells and Particles as Small as 0.2 Microns

Published: Monday, March 03, 2014
Last Updated: Thursday, March 13, 2014
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Beckman Coulter Life Sciences launched the Multisizer 4e COULTER COUNTER at Pittcon 2014.

The latest Multisizer 4e features a new 10-micron aperture that enables users to obtain accurate count, size and mass distribution for particles and cells ranging from 0.2 to 1,600 microns.  Digital Pulse Processing provides high-resolution analysis in as many as 400 channels for unparalleled performance in pharmaceutical quality control, bioprocessing and industrial applications.

Incorporating the latest technology and software advances, the Multisizer 4e with unique Digital Pulse Processing delivers dynamic size measurements in real time.  High-speed signal digitalization allows the use of various pulse parameters for more accurate cell and particle characterization.  Response is unaffected by particle color, shape, composition or refractive index. Biotech applications include monitoring of transfection, counting mitochondria, organelles and other intracellular components, and characterizing changes in cell size when changes are made to cultures.  In these applications the volumetric analysis of the Multisizer 4e provides a more accurate and informative measurement than measuring size alone.

“Counting sub-visible particles, measuring volume as well as count and size, monitoring hundreds of channels at once — all of these features provide analysts with a highly useful and versatile instrument,” said Matthew Rhyner, PhD, Particle Characterization senior global business manager at Beckman Coulter Life Sciences.  “The 4e is an important addition to the Multisizer line, and we look forward to the great work that will be done with it by our customers.”

Sub-visible particle capability means that pharmaceuticals can be analyzed for compliance with USP 788 guidelines, to ensure product cleanliness. Multisizer 4e is also compliant with 21 CFR Part 11.  Industrial applications range from ink toners to cosmetics, from environmental studies to the monitoring of filter efficiency, and many others.

Instrument operation is completely computer controlled, and intuitive software with wizards and menu driven set-up assists both beginners and experienced users.  Sample management system using Smart Technology provides consistency from one analysis to the next.

The Multisizer 4e is the newest member of the COULTER COUNTER product family and the latest advancement in a long line of cell counting and sizing instruments. Since 1956, when the first COULTER COUNTER Model A was released, there have been 58 years of successful innovation using the COULTER Principle, making Beckman Coulter one of the leading companies in particle characterization today.


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