Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Crown Bioscience to Showcase Progression in Human Surrogate Trials

Published: Wednesday, May 21, 2014
Last Updated: Wednesday, May 21, 2014
Bookmark and Share
HuTrialTM demonstrates commitment to furthering preclinical understanding in order to improve personal care and increase patient recovery rates.

Crown Bioscience, Inc. will showcase their human surrogate trial platform at the 50th Annual ASCO Conference, taking place in Chicago, US, between 30th May and 3rd June. The HuTrialTM platform enables drug discovery and development companies to optimize their screening processes to ensure that only the most effective candidates are accelerated through to the clinic and onto improving patient care.

The most significant limitation to the development of new treatments in oncology is undoubtedly cost prohibition, as the attrition of a drug in the final stages of clinical trials carries significant financial implications for drug development. The HuTrial substitutes Phase-II trials at reduced cost, providing the opportunity for early decision making regarding drug candidate progression and significantly decreasing the risk of promoting ineffective therapeutics through the later stages of clinical testing.

The HuTrialTM platform substantially reduces the time and cost of phase-II trials and when used to identify patient biomarkers, it can effectively predict the clinical response of a prospective candidate before undergoing rigorous clinical testing. By evaluating all prospective treatments, surrogate trials can improve the success rate with which effective therapeutics reach the clinic and help reduce the chances of patients experiencing harmful or unpleasant side effects. HuTrials are conducted using Crown’s HuPrime® patient derived xenografts (PDX), where primary tumor cells are extracted directly from a patient and transplanted into surrogate, in most cases immunodeficient mice. As the cancer develops, prospective treatments can be administered to the surrogate host and the efficacy of prospective drug candidates can be observed and evaluated.

Jean-Pierre Wery, the President of Crown Bioscience comments; “At Crown Bioscience we are committed to improving the decision making process involved in submitting drug candidates for phase II and III clinical trials. As the most significant factor affecting the advancement of drug development is the cost of drug attrition in the later stages of clinical trials, it is important that we ensure that our clients do not waste resources on ineffective treatments. If we can assist them in identifying promising candidates early on, we can improve the rate at which effective new treatments are delivered into the clinic to improve patient outcomes. The HuTrialTM platform has the potential to help alleviate the socio-economic burden cancer has on the healthcare industry and assist in the global effort to convert cancer from a terminal condition to a chronic disease.”

The acclaimed ASCO Annual Meeting is attended by more than 25,000 oncology professionals, across a broad range of specialties. The itinerary includes workshops, education sessions, discussions, symposia and poster presentations to highlight clinical issues and frontline research and discovery. By bringing together individuals at the forefront of their respective fields, ASCO endeavors to unite the international oncological community with a view to sharing expertise, exploring new ideas, and further developing clinical and research techniques.




Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Crown Bioscience Passes 1000 Model Mark in PDX Collection for Oncology Drug Discovery
Size of collection allows for more informed preclinical decision making on prospective drug candidates.
Wednesday, April 23, 2014
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Protein Related to Long Term Traumatic Brain Injury Complications Discovered
NIH-study shows protein found at higher levels in military members who have suffered multiple TBIs.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
Crystal Clear Images Uncover Secrets of Hormone Receptors
NIH researchers gain better understanding of how neuropeptide hormones trigger chemical reactions in cells.
New Tool Uses 'Drug Spillover' to Match Cancer Patients with Treatments
Researchers have developed a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best "kinase inhibitor" to silence these dangerous genetic causes of disease.
HIV Susceptibility Linked to Little-Understood Immune Cell Class
High levels of diversity among immune cells called natural killer cells may strongly predispose people to infection by HIV, and may be driven by prior viral exposures, according to a new study.
Sweet Revenge Against Superbugs
A special type of synthetic sugar could be the latest weapon in the fight against superbugs.
Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support
A new study reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!