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New 1mL ISOLUTE® SLE+ 48-well Plates from Biotage

Published: Tuesday, June 17, 2014
Last Updated: Wednesday, June 18, 2014
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Enabling the extraction of larger sample volumes, faster! Med chem, proteomics, bioprocessing and screening

Biotage announces the launch of the new ISOLUTE® SLE+ 1 mL Supported Liquid Extraction 48-well plates, enabling the extraction of larger sample volumes (1 mL total load volume) than presently possible in the microplate footprint.

The new ISOLUTE® SLE+ 1 mL sample volume 48-well plates are packed with ISOLUTE SLE+ material; each well containing sufficient ISOLUTE® SLE+ material to efficiently extract 1 mL of aqueous sample.  Existing 96-well formats have a maximum capacity of 400 µL, the new plates enable customers to extract larger sample volumes and therefore achieve higher sensitivity, higher throughput and lower detection limits.

The new plates are ideal for the extraction of small molecule drugs, metabolites and endogenous biomarkers from biological fluid samples prior to analytical techniques such as LC-MS/MS and GC-MS. Analytical chemists in clinical, forensic toxicology and Pharmacology will appreciate the high throughput and extra sample capacity.

As with the other products in the ISOLUTE® SLE+ range, the same simple load-wait-elute procedure is used with this new 48-well format reducing method development time.

The plates can be processed using microplate compatible positive pressure manifolds, such as the Biotage® Pressure+ 96, vacuum manifolds such as the Biotage® VacMaster™ 96 and most automated liquid handling systems.

The plate is arranged in a 6 x 8 array; with 48 samples being processed per plate a higher throughput than equivalent column formats is achievable. A new compatible 48-well collection plate is also available with a 5 mL capacity so that the entire elution solvent volume can be collected with no need to swap collection vessels.


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