Ubiquigent, Cyclofluidic Enter Collaboration

Ubiquigent Limited, a company specialising in ubiquitin cell-signalling system drug discovery capabilities and services, and Cyclofluidic Limited, a leading medicinal chemistry company based on an innovative integrated discovery technology platform, announced today they have entered into an agreement to develop novel targeted libraries that specifically target the ubiquitin system.

Under the terms of the agreement, Ubiquigent and the Cyclofluidic will design, develop and characterise small molecule compound libraries by combining their two leading approaches:

Ubiquigent – Ubiquigent provides access to a full suite of drug discovery services and high integrity reagents and kits to help investigators unravel the complexity of, and pursue, new therapeutic target opportunities across the ubiquitin system. Ubiquigent designs HTS-ready assays and undertakes complex drug discovery services on targets such as the ubiquitin ligases (E3s), ubiquitin deconjugating enzymes (DUBs, DUBprofiler™), and other system targets to support research in this rapidly emerging field.

Cyclofluidic - The CyclOps™ platform integrates flow chemistry, purification, screening and drug design utilising machine learning algorithms to allow drug lead molecules to be assayed minutes, rather than weeks, after they are designed. The team has shown that use of the platform reduces timelines for hit to lead optimisation by 50%, from a year to less than 6 months, allowing molecules to progress into pre-clinical studies faster.

The output of the collaboration will be a valuable source of novel targeted libraries that the companies will jointly commercialise. These libraries will provide new medicinal chemistry opportunities to support the identification of potent and selective compounds that target key members of this family of new drug targets, which have been implicated across multiple therapeutic areas including: cancer, cardiovascular and metabolic, neurological and musculoskeletal, and infection and immunity.

Commenting on the collaboration, Dr. Jason Brown, Managing Director of Ubiquigent, said: “We are very pleased to be entering into this relationship with Cyclofluidic as we believe that our combined approach will uncover many exciting opportunities in this rapidly developing field. This latest collaboration further supports Ubiquigent’s goal of being the first, ubiquitin system-focused, fully integrated provider of biology, assays, small molecule libraries and compound profiling services.”

Dr. Dave Parry, Chief Operating Officer of Cyclofluidic, added: “We are excited by the opportunity to demonstrate the advantages of our CyclOps™ platform in accelerating discovery to this rapidly evolving area of biology which has been made possible through access to Ubiquigent’s leading expertise in the field.”