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Tuesday, July 22, 2014
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Geneset-based cancer survival analysis: On the non-uniform distributiuon of p-values under the null hypothesis
Esteban Czwan, Benedikt Brors, David Kipling

Although null p-values are assumed to be uniformly distributed in gene expression experiments, the actual distribution often deviates from the assumed distribution. This can incorrectly associate the biology of a geneset with cancer prognosis in geneset-based survival studies. To assess the implications of this, a geneset-based method was developed. This method empirically approximates the distribution of null p-values and tests whether predefined sets of biologically-related genes are associate

Functional Screening of recombinant CHO-M1 cells using the PHERAstar from BMG LABTECH
Bernd Laffert1 and Franka Ganske2

Functional screening of single cell clones was achieved using the HTRF® IP-One assay. The HTRF® assay from Cisbio proved to be a fast and reliable method to directly screen a large number of stable transfected single cell clones. Carbachol dose response curves with fresh cells from a growing culture and frozen instant cells showed similar results for EC50 and signal-to-blank values.

Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2, 3-dioxygenase involved in degradation of polychlorinated biphenyls
M. Saqib Baig and N. Manickam

The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the docking results. The binding properties of these biphenyl compounds along with identification of critical active site residues could be used for further site-directed mutagenesis experiments in order to identify their role in activity and substrate specificity.

Treatment of Plaque Infections and Periodontitis using Stem Cells- A New Prospect
Manoj Hariharan , Naveen Raj

Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This paper gives a short overview of stem cells of dental origin.

Reactome - a knowledgebase of human biological pathways
Esther E Schmidt, Michael Caudy, David Croft, Bernard de Bono, Phani V Garapati, Gopal Gopinath, Marc Gillespie, Robin Haw, Bijay Jassal, Steven Jupe, Alexander Kanapin, Shahana Mahajan, Lisa Matthews, Bruce May, Gavin O’Kelly, Imre Vastrik, Guanming Wu, Ewan Birney, Peter D'Eustachio, Lincoln Stein

Reactome is a manually curated knowledgebase, created and peer-reviewed by experts in their field. Its robust data model describes life processes ranging from metabolism to signal transduction and the cell cycle. As of release 28, Reactome contains 3700 human proteins in 3200 reactions. Data is cross-referenced to publicly available web-based informatics resources. Reactome features the SkyPainter tool for analysis of high-throughput datasets, and the Mart query and data retrieval tool.

Panic attack and suicide risk: A multivariate logistic regression analysis of a national epidemiological survey
Curren Katz, Ramin Mojtabai, Leo Bierman, Kathleen Camacho, Janine Samuel, Gillian Jennings, Igor Galynker

To examine the relationship between panic attack and suicide risk, we analyzed data from a representative epidemiological survey of 43,093 adults (NESARC) using logistic regression controlling for socio-demographic and clinical variables. In depression, panic attacks are associated with increased odds of suicide attempt even after controlling for demographic and clinical variables. Furthermore, panic attacks can differentiate those who attempt suicide from those with ideation only.

Panic attack and suicide risk: A multivariate logistic regression analysis of a national epidemiological survey
Curren Katz, Ramin Mojtabai, Leo Bierman, Kathleen Camacho, Janine Samuel, Gillian Jennings, Igor Galynker

To examine the relationship between panic attack and suicide risk, we analyzed data from a representative epidemiological survey of 43,093 adults (NESARC) using logistic regression controlling for socio-demographic and clinical variables. In depression, panic attacks are associated with increased odds of suicide attempt even after controlling for demographic and clinical variables. Furthermore, panic attacks can differentiate those who attempt suicide from those with ideation only.

Nonlinear Dynamic Models for Single-Cell Time-Lapse Microscopy
Jarad Niemi, Cheemeng Tan, Lingchong You, Mike West

This poster applies Bayesian analysis of nonlinear dynamic models to time-lapse fluorescent microscopy data.

Nonlinear Dynamic Models for Single-Cell Time-Lapse Microscopy
Jarad Niemi, Cheemeng Tan, Lingchong You, Mike West

This poster applies Bayesian analysis of nonlinear dynamic models to time-lapse fluorescent microscopy data.

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Showing Results 91 - 100 of 254
Scientific News
Innovative Technology Enables First Crystal Structure of mGlu5 Transmembrane Domain to be Determined
Several novel drug candidates have been identified to help treat specific neuropsychiatric disorders.
Capturing Cancer: A Powerful New Technique for Early Diagnosis
Researchers describe an innovative technique for early disease detection, which they call immunosignaturing.
Significant Step Towards Blood Test for Alzheimer's
Scientists have identified a set of 10 proteins in the blood which can predict the onset of Alzheimer’s, marking a significant step towards developing a blood test for the disease.
Potential Alzheimer’s Drug Prevents Abnormal Blood Clots in the Brain
Researchers have identified a compound that might halt the progression of Alzheimer’s by interfering with the role of plaque forming amyloid-ß.
CRI Finds Key to Identifying, Enriching Mesenchymal Stem Cells
Biomarker enables researchers to accurately characterize the properties and function of MSCs in the body.
Finding Could Revolutionize Drug Discovery
A study by researchers at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Advanced Cell Culture Techniques for Cancer Drug Discovery
This review focuses on the culturing of cell lines representative of solid cancers in advanced cell culture conditions.
Detailed Brain Imaging Study to Help Unlock Root Causes of Dementia
Large population scanning heralds a new era in research to tackle dementia and a wide range of intractable diseases.
Combining Weak Chemical Forces to Strengthen a Novel Imaging Technology
Illinois researchers turn current contrast agent technology on its head—or rather, they turn it inside out.
Chemists Discover Cancer Drug Candidate Structure
Chemists at The Scripps Research Institute have determined the correct structure of a highly promising anticancer compound approved by the U.S. FDA for clinical trials in cancer patients.

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