Widely accepted as the gold-standard for ultra low-noise patch clamp recordings, the Axopatch™ 200B Capacitor Feedback Patch Clamp Amplifier is the benchmark for single-channel recordings and other applications that require an excellent signal-to-noise ratio. By introducing active cooling of components in the headstage to well below 0°C, the open-circuit noise in patch mode has been reduced to unprecedented levels, as low as <15 fA (RMS) at 0.1 - 1 kHz. This translates into significantly lower noise during patch clamp recordings. A headstage that can be switched to resistive mode ensures superb performance in whole-cell recordings, too. This makes the Axopatch 200B System the amplifier of choice for a scientist who performs basic research in the ion channel field and is the reason why researchers purchased thousands of these amplifiers from Molecular Devices over the past decade.
In addition to ultra-low noise and whole-cell performance, the slim design of the headstage improves electrode access to the preparation by making it easier to fit under your microscope. The Axopatch 200B Amplifier gives you the utmost flexibility through three recording configurations in a single headstage: one patch and two whole cell ranges, with capacitance compensation ranges of 100 pF and 1000 pF. Increased voltage and current command ranges (up to ±1V) are useful for electrochemical measurements. The built-in capacitance dithering capability enables highly accurate capacitance measurements. Seal test has become more versatile, featuring current steps in current clamp mode as well as voltage steps in voltage clamp mode. The recording bandwidth has been extended up to 100 kHz, allowing you to capture even the fastest events. Series resistance compensation is active in current clamp as well as in voltage clamp mode to enable bridge balance operation and improve amplifier performance.