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High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
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The Do’s and Don’ts of SPR Experiments
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Long-Sought Protein Sensor for the ‘Sixth Sense’ Discovered
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New Anti-Malarial Drug Screening Model
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Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
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Comparison of Photina Luminescent Calcium Mobilization Assays on both the FlexStation® 3 and FLIPRTETRA® Systems
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Molecular Devices

G-protein coupled receptors (GPCRs) represent one of the most important therapeutic targets in drug discovery research. GPCRs are membranelocalized proteins that play an important role in cell signaling. When a receptor is activated by a ligand, the conformation of the receptor is modified, activating G-proteins inside the cell. An active G-protein has the potential to induce various cascades of intracellular messengers, including calcium.

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