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Scientific News
Direct Drug Screening Of Biopsies Could Overcome Resistance
Combining genetic with pharmacologic screening of tumors may enable truly individualized treatment regimens.
Almac Announces Launch of CLIA Validated Next Generation Sequencing Assay
P53 considered important biomarker for cancer drug discovery.
Next-Gen Melanoma Drug Excels in Lab Tests
Anti-cancer activity was reported in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733.
Blood Test Could Reduce Antibiotic Use
A new blood biomarker test that indicates whether bacteria is the cause of a patient’s lung infection is now being studied at UPMC Presbyterian.
New Targets and Test to Develop Treatments for Memory Disorders
The study focuses on kinesin, a molecular motor protein that plays a role in the transport of other proteins throughout a cell.
Drugging the Undruggable
Discovery opens up possibility of slowing cancer spread.
Classification of Gene Mutations in Neuroblastoma
Penn Medicine and CHOP experts define riskier mutations in neuroblastoma, setting stage for clinical trial.
Microscopic “Walkers” Find Their Way Across Cell Surfaces
Technology could provide a way to deliver probes or drugs to cell structures without outside guidance.
Study Investigates Inherent Contamination in Deep Well Microplates
Study gives data on microplates from numerous manufacturers based in Europe, USA and China.
Culture System Replicates Course Of Alzheimer’s Disease
Three-dimensional system should significantly reduce time and costs of drug development.

Voltage-Gated Sodium Channel Activators with Differing Efficacies Stimulate Neurite Outgrowth in Cerebrocortical Neurons
Thomas Murray, Professor and Chair, Creighton University School of Medicine, speaking at Screening Europe 2010

What Are The Right Assays to Select? Studies With Receptors for Free Fatty Acids’
Graeme Milligan, Professor, University of Glasgow, speaking at Screening Europe 2010

Indirect Inhibition Assays and Droplet-Based Microfluidics
Christoph Merten, Junior Group Leader, University of Strasbourg, speaking at Screening Europe 2010

Thermo-TRP Ion Channels as Drug Targets
Peter McNaughton, Professor, University of Cambridge, speaking at Screening Europe 2010

Physiologically Based Pharmacokinetic/Pharmacodynamic Modelling for Lead Optimisation of CNS-Active Therapeutics
Simon Thomas, Cyprotex, speaking at Screening Europe 2010

Predicting Hepatotoxicity with CellCiphr HCS technology: Rat and Human Hepatotoxicity Predicton: Validation and Case Studies
Katya Tsaioun, CSO, Cyprotex speaking at ADMET Europe 2011

Diversity Screening for Alternate Modes of Inhibition of Protein Kinase Targets
Julio Martin, Group Manager, GlaxoSmithKline, speaking at Screening Europe 2010

Screening in the Spanish Public Chemical Library (ChemBioBank)
Mabel Garcia Loza, Associate Professor, University of Santiago de Compostela, speaking at Screening Europe 2010

Enabling High Throughput Mass Spectrometry for Compound Profiling of Enzyme Targets
Melanie Leveridge, Scientist, GlaxoSmithKline, speaking at Screening Europe 2010

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