Charting Kidney Cancer Metabolism Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.Insights into the Function of the Main Class of Drug Targets About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.Visualizing a Cancer Drug Target at Atomic Resolution Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.Honey’s Potential to Save Lives The healing powers of honey have been known for thousands of years. 3-D Printed Lifelike Liver Tissue for Drug Screening A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling. Cytoskeleton Crew Findings confirm sugar's role in helping cancers survive by changing cellular architecture.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University. Valvena, GSK Sign New R&D Collaboration Valneva to supply process development services for EB66® -based Influenza vaccines. Light Signals from Living Cells Fluorescent protein markers delivered under high pressure.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors Lee Walmsley, Vernalis Ltd, speaking at Discovery Chemistry Congress 2015.
Investigating the Kinetics of cAMP Accumulation in Human Primary Cells Using a Live-Cell cAMP Biosensor Elizabeth Rosethorne, Novartis, speaking at Advances in Biosensors and Biodetection.
Modifying Cell Lines for Target Discovery and Validation In this 30-minute seminar, we will discuss the process of genome editing, address factors affecting the design of a genome editing project, and explore the application of modified cell lines for target discovery and validation.
Strategies for the Identification of Lead Molecules to Sustain a Discovery Organisation Steve Rees, AstraZeneca, speaking at Drug Discovery and Development 2014
Kinases as Targets for Drug Discovery in an Academic Setting William Janzen,The University of North Carolina at Chapel Hill, speaking at Drug Discovery and Development 2014
Machine Learning for Building Models of Cell Perturbation Robert Murphy, Carnegie Mellon University, speaking at Drug Discovery and Development 2014
Balancing Leverage with Stewardship of a Corporate Compound Collection Rose Gonzales, Pfizer Global R&D, speaking at Drug Discovery and Development 2014
Heterogeneity of Cellular Responses to Perturbagens in Drug Discovery and Development Lansing Taylor, University of Pittsburgh, speaking at Drug Discovery and Development 2014
Repurposing Approaches for Rare and Neglected Tropical Diseases John Mckew, National Institutes of Health, speaking at Drug Discovery and Development 2014