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Scientific News
Direct Drug Screening Of Biopsies Could Overcome Resistance
Combining genetic with pharmacologic screening of tumors may enable truly individualized treatment regimens.
Almac Announces Launch of CLIA Validated Next Generation Sequencing Assay
P53 considered important biomarker for cancer drug discovery.
Next-Gen Melanoma Drug Excels in Lab Tests
Anti-cancer activity was reported in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733.
Blood Test Could Reduce Antibiotic Use
A new blood biomarker test that indicates whether bacteria is the cause of a patient’s lung infection is now being studied at UPMC Presbyterian.
New Targets and Test to Develop Treatments for Memory Disorders
The study focuses on kinesin, a molecular motor protein that plays a role in the transport of other proteins throughout a cell.
Drugging the Undruggable
Discovery opens up possibility of slowing cancer spread.
Classification of Gene Mutations in Neuroblastoma
Penn Medicine and CHOP experts define riskier mutations in neuroblastoma, setting stage for clinical trial.
Microscopic “Walkers” Find Their Way Across Cell Surfaces
Technology could provide a way to deliver probes or drugs to cell structures without outside guidance.
Study Investigates Inherent Contamination in Deep Well Microplates
Study gives data on microplates from numerous manufacturers based in Europe, USA and China.
Culture System Replicates Course Of Alzheimer’s Disease
Three-dimensional system should significantly reduce time and costs of drug development.

Kinetic Monitoring of Cellular cAMP/cGMP Signalling
Reinhard Seifert, Sibion Biosciences, speaking at Screening Europe 2011

From Acquisition to Analysis: Tools to Improve the High Content Screening Workflow for Stem Cell Assays
Ben Haworth, Molecular Devices, speaking at Screening Europe 2011.

Development of an Ultra-high Throughput Long Non-coding RNA Screening System
Jan Hellemans, speaking at Advances in qPCR 2011

Latent Hit Identification in Primary Screening Data with Compound Set Enrichment
Thibault Varin, PostDoctoral Fellow, Novartis, Speaking at Medchem Europe 2011.

State-of-the-Art in Ligand-Based Virtual Screening
Jürgen Bajorath, Professor, Department of Life Science Informatics, University of Bonn, speaking at Medchem Europe 2011.

Enhancing Success Rates in Virtual Screening
Giulio Rastelli, Associate Professor in Medicinal Chemistry at the University of Modena, speaking at Medchem Europe 2011.

Preclinical Drug Safety: High Quality Data obtained with a New Automated Patch Clamp Platform
Olaf Scheel, CSO, Cytocentrics AG speaking at Pharma Outsourcing Congress 2011

Multiplex Target Screening by High Throughput Flow Cytometry
Larry Sklar, Professor, University of New Mexico Health Sciences Center, speaking at Screening Europe 2010

The Potential of Selected Adenylyl Cyclases Isoforms as Potential Drug Targets
Klaus Scholich, Institute of Clinical Pharmacology, Goethe University Frankfurt, speaking at Screening Europe 2010

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