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Featured Product - UltraCruz® ELISA Plate
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Webcasts
Webcast - Webinar: Human Recombinant Antibodies as Positive Controls and CalibratorsWebinar: Human Recombinant Antibodies as Positive Controls and Calibrators
Join this webinar to find out how we use the HuCAL® antibody library and phage display technology to generate custom recombinant antibodies as alternatives to human and animal sera.
Advanced Molecular Tools for Proteome Analyses
Masood Kamali-Moghaddam, Uppsala University, speaking at Advances ibn qPCR and dPCR 2014

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Chromatography Resin Market by Application, Techniques & Type - Trends & Forecast to 2018
MarketsandMarkets

The chromatography resin market is expected to grow at a decent pace during the coming decade driven by its increasing application in monoclonal antibody production and food analytics.
Cell Analysis Market by Instruments, Consumables & Application - Global Forecast to 2018
MarketsandMarkets

The global cell analysis market is a technology-driven market and is marked by the ?Threat of Obsolescence,? wherein technologies as well as their adoption by end users changes very rapidly. Hospitals, academic and government institutes, as well as pharmaceutical and biotechnology companies are increasing their focus on using cell analysis as a powerful research tool in research, drug discovery, and diagnosis.
Security Technologies in Biotechnology
RI Technologies

The report serves as a guide to security technology industry for biotechnology applications, covering more than 350 companies that are engaged in security technology/products and services.
Blood - Components, Testing & Collection
RI Technologies

This market insight report gives an insight into global blood ? components, testing and collection market. The report also provides market analytics by Product Type.
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
Life Science Consumables 2013: Markets and Opportunities
Biopharm Reports

Techniques such as PCR, DNA microarray, DNA sequencing, mass spectrometry and flow cytometry have grown significantly in the last decade and by 2015 markets for these five areas are expected to exceed $50 billion, globally. In these and related fields, consumables are generally the second or third largest area in cost terms, after instrumentation.
Scientific News
A New Path Towards a Universal Flu Vaccine
New research suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus.
$1.35 Million Grant to Better Predict Flu Outbreaks
An international research team will receive $1.35 million from the Human Frontier Science Program Organization to better understand how the influenza virus passes from birds to humans.
Too Exhausted to Fight – and to do Harm
An ‘exhausted’ army of immune cells may not be able to fight off infection, but if its soldiers fight too hard they risk damaging the very body they are meant to be protecting, suggests new research from the University of Cambridge.
Researchers Develop a New Means of Killing Harmful Bacteria
Engineered particles are capable of producing toxins that are deadly to targeted bacteria.
Iron: A Biological Element?
Study shows findings which have meaning for fields as diverse as mining and the search for life in space.
Team Led by TSRI Scientists Shows AIDS Vaccine Candidate Successfully ‘Primes’ Immune System
New research shows that an experimental vaccine candidate can stimulate immune activity necessary to prevent HIV infection.
New Tool Identifies Novel Compound Targeting Causes of Type 2 Diabetes
Study identifies small-molecule compound that protects cells against ER stress.
New Immunoregulation and Biomarker
Clinicians at LMU have elucidated a mechanism involved in determining the lifespan of antibody-producing cells, and identified a promising new biomarker for monitoring autoimmune diseases.
Seashells to Deliver New Drugs and Vaccines
Australian scientists have developed a protective seashell-inspired capsule to preserve the active biological ingredients needed to create new drugs.
HIV Paradox
Investigators from Harvard Medical School, Massachusetts General Hospital, and the Ragon Institute of MGH, MIT and Harvard have added another piece to the puzzle of how a small group of individuals known as elite controllers are able to control HIV infection without drug treatment.
Business News
Crown Bioscience Expands its Partnership with The National Resource Center for Mutant Mice
The expanded collaboration will focus on developing immuno-oncology mouse models and other disease-specific experimental models supporting translational medical research.
Lilly and Immunocore Announce Collaboration
Collaboration to explore the utility of IMCgp100 in combination with Lilly's galunisertib and merestinib for melanoma treatment.
Celgene Launches $1B Immunotherapy Collaboration with Juno
Celgene and Juno Therapeutics have launched a 10-year global collaboration to develop and commercialize cancer and autoimmune diseases immunotherapies.
Big Plans and 40 Years of Experience
Rudi Vollmer becomes new Technical Managing Director of Greiner Bio-One GmbH, responsible for production and technology.
Amarna Therapeutics Teaming Up with Austrian CBmed
Cooperation for the development of immunotherapies against ALL, obesity, diabetes mellitus type 2 and ASCVD.
TxCell Announces FDA Acceptance of IND for Ovasave
IND grants TxCell option of extending current phase 2b study from EU to US.
Thermo Fisher Agrees to Buy Alfa Aesar for $403M
The company announced a definitive agreement to buy the research chemical manufacturer for $403 million.
Broad Institute & Google Genomics Combine Bioinformatics and Computing Expertise
Both companies explore how to break down major technical barriers that increasingly hinder biomedical research.
First Drug Discovery Project from £3m Dementia Consortium
Funding worth nearly half a million pounds will unite academics at the University of Southampton with drug discovery experts at the medical research charity MRC Technology, to target the immune system in the hunt for new treatments for Alzheimer's disease.
Agalimmune Licenses KODE Biotech’s FSL Technology
Deal worth up to $31M USD (£21 million GBP).

Events
Allergies 2015
08 Jul 2015
Allergies 2015 ...
12th Anti-Infectives Partnerin
08 Jul 2015
12th Anti-Infectives Partnerin ...
4th Influenza Research and Dev
08 Jul 2015
4th Influenza Research and Dev ...
ON Helix
14 Jul 2015
ON Helix ...

ePosters
Modelling CLL cell and T-cell Migration in a Dynamic Circulating Model of CLL
'Cardiff CLL Research Group, Institute of Cancer & Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK. 2CRUK Institute for Cancer Studies, University of Birmingham, Vincent Driv

We have recently developed a novel circulating model of chronic lymphocytic leukaemia (CLL) that mimics the transient interactions that take place between circulating lymphocytes and vascular endothelium. Here we show that both normal and malignant lymphocytes actively underwent transendothelial migration.
Quantification of Natural Killer Cell-Mediated Cytotixicity using Celigo Imaging Cytometry
Nexcelom Bioscience LLC, The University of Texas MD Anderson Cancer Center

Time-course tracking of % lysis eliminates multiple controls & the effect of non-uniform cell seeding in the final cytotoxicity calculation. The # of cells used is less than the cells needed for Release assays & Flow Cytometry. Flow cytometry & Release assays require a seeding density of 100K target cells increasing the number of effector cells to the millions. The visual observation of ADCC or CDC on the images can be convincing to conclude the functionality of antibodies or complements.
Novel culture medium using a small-molecule agonist of thrombopoetin receptor
1ReproCELL, Inc. & 2Nissan Chemical Industries

ReproHSC medium for the culture of hematopoietic stem cells. facilitates the culture and expansion of CD34+/CD38- cells that retain their HSC properties
Flexible automated platform for blood group genotyping on DNA microarrays
1 Établissement Français du Sang Rhône-Alpes, Lyon, France. 2 Établissement Français du Sang, La Plaine Saint Denis, France. 3 Établissement Français du Sang Alpes-Méd

The purpose of this project was to set up and validate a flexible robotic platform using 96-well DNA microarray for multiplex blood group genotyping.
Non-invasive Liquid Biopsy
1 Life Technologies AS, Ullerchausséen 52, 0379, Oslo, Norway; 2Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; 3 Centre for Cancer Biomedicine, Univ

Paramagnetic Dynabeads® magnetic beads provide a versatile, automation friendly tool for fast sensitive and high throughput isolation that can be tailored to isolate specific circulating biomarkers such as cells, exosomes and nucleic acids.
THE MASTOCYTOSIS SOCIETY SURVEY ON MAST CELL DISORDERS: Part 2-Clinical Experiences, Co-Morbidities, Diet, Families and Opinions
The Mastocytosis Society, Inc., USA; Mastocytosis Center, Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, U

Mast cell diseases such as mastocytosis and mast cell activation syndromes involve abnormal proliferation or activation of these cells leading to many potentially debilitating symptoms. In order to determine the characteristics and experiences of people known or suspected to have a mast cell disorder, The Mastocytosis Society (TMS), a U.S. based patient advocacy, research and education organization, conducted a survey of patients.
Safety Of A Sublingual Tablet of House Dust Mite Allergen Extracts In An Environmental Exposure Chamber Study
Stallergenes, Antony, France

In an environmental exposure chamber (EEC) study, treatment with HDM sublingual tablets in patients with HDM-associated allergic rhinitis was generally well tolerated regardless of dose. While asthma and related symptoms were more common during the peri-EEC challenge periods, rates did not differ between active and placebo treatment.
Safety Of The 300 IR and 500 IR Doses Of A House Dust Mite Allergen Extracts Sublingual Tablet In Adults with Allergic Rhinitis
Stallergenes, Antony, France

In a randomized, DBPC study in patients with HDM-associated allergic rhinitis, treatment with HDM sublingual tablets at doses of 300IR and 500IR was associated with a favorable safety profile. There was no appreciable difference in tolerability between the tested doses.
Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM


Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge Theatre
Field Performance of a New Technology with the Potential to Identify Allergy and Asthma Triggers
Inspirotec LLC, Glenview, IL, Argonne National Laboratory, Lemont, IL, Department of Ecology and Evolution, University of Chicago, Chicago, IL

This work introduces a very simple plug-and-play device that can sample air at a high volume flow rate with no moving parts. Aerosol particles are captured on electrodes and eluted for testing. We show that performance of the device is substantially equivalent to capture by pumping through a filter for immunological and molecular analysis.
Application Notes
Characterization of IgG Monomers & Their Aggregates
Malvern Instruments Limited

In this application note we characterize two antibody samples using column calibration and multi-detection SEC.
Understanding Antibody and Viral Glycoprotein Interactions Using CG-MALS
Wyatt Technology Corporation

We used size-exclusion chromatography coupled with multi-angle light scattering to determine the molar mass and native oligo-meric state of a viral glycoprotein.
Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Wyatt Technology Corporation

Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Tag-lite® two-cell assay: a valuable tool for protein drug discovery
Tecan Group Ltd.

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.
Transcreener® ADP2 TR-FRET Red Assay
Tecan Group Ltd.

Adenosine diphosphate (ADP) is an important mediator of cellular metabolism that is essential for maintaining energy levels. The Transcreener ADP2 TR-FRET Red Assay is intended for the detection of ADP production by any kinase or ATPase, and has been developed specifically for high throughput screening applications.
Efficient washing of magnetic beads
Tecan Group Ltd.

The use of magnetic beads as the solid phase in a multiplexed ELISA enables high throughput cytokine screening and offers several advantages over common ELISA assays with direct coupling of the analyte to the well-surface.
Automating ELISAs on Tecan’s Freedom EVO® using Optimiser™ technology from Siloam Biosciences
Tecan Group Ltd.

One of the challenges in life sciences research today is to discover methods for running key assays more quickly, more reliably and using lower volumes of reagents and sample, but still with improved sensitivity. One area where this particularly holds true is for traditional enzyme-linked immunosorbent assays (ELISAs), whose application provides a useful measurement of antigens, including cytokines and a host of other biomarkers.
Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.
A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.
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