Thursday, May 17, 2012
Technology Networks
Technology Networks
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 | Protein and Peptide Arrays for Studying Autoimmunity Professor Paul J. (P.J.) Utz, Stanford University, speaking at Microarray World Congress. |
 | Validation of Biomarkers In Tissue Dr Stephen M. Hewitt, National Cancer Institute, speaking at Microarray World Congress 2011. |
Live Cell Kinetic Imaging Trends
HTStec
This market report summarizes the results of HTStec’s 2nd global web-based benchmarking survey on live cell kinetic imaging assays and instruments carried out in May 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Cancer Targeted Therapies and Immunotherapies Market Forecast
Datamonitor plc
The oncology market has witnessed a sizeable shift of focus away from cytotoxic therapies and antihormonal therapies towards the more lucrative targeted therapies and immunotherapies class in the last decade. This class boasts several of the top-selling anticancer brands overall, and has fueled most of the recent rapid growth of the oncology market as a whole.
In Vitro Diagnostics (Immunochemistry and Infectious Immunology) Global Market Briefing to 2016
GlobalData
This report provides key data, information and analysis on the global immuno chemistry and infectious immunology markets. The report provides market landscape, competitive landscape and market trends information the immuno chemistry and infectious immunology markets. The report provides comprehensive information on the key trends affecting the market, and key analytical content on the market dynamics. The report also reviews the competitive landscape and technology offerings.
Monoclonal Antibodies: 2010
Datamonitor plc
Across the branded prescription pharmaceutical market monoclonal antibodies (MAbs) are forecast to be the strongest performing molecule type, delivering a forecast six year compound annual growth rate of 9.5% over 2009-15, outpacing the growth rates of small molecules, therapeutic proteins and vaccines.
Manufacturing of Biologics - Increasing Demand for Monoclonal Antibodies and Recombinant Proteins Drives Increases in Capacities and Innovative Production Technologies
GBI Research
GBI Research's report, “Manufacturing of Biologics - Increasing Demand for Monoclonal Antibodies and Recombinant Proteins Drives Increases in Capacities and Innovative Production Technologies”, provides the key data and analyzes the major challenges and drivers for the biomanufacturing industry. The report also analyzes the strengths, weaknesses of and opportunities for the stakeholders in the manufacturing of biologics.
Competitor Analysis Biosimilar and Biobetter/Biosuperior Antibodies
La Merie
The present Competitive Intelligence Report about Biosimilar and Biobetter/Biosuperior Antibodies provides a competitor evaluation in the field of recombinant monoclonal and polyclonal antibodies directed against CD20, Her2, VEGF, TNF, EGF-R, RSV and GPIIb/IIIa as of October 2010.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd
This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
HTStec
This market report summarizes the results of HTStec’s 2nd global web-based benchmarking survey on live cell kinetic imaging assays and instruments carried out in May 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Cancer Targeted Therapies and Immunotherapies Market Forecast
Datamonitor plc
The oncology market has witnessed a sizeable shift of focus away from cytotoxic therapies and antihormonal therapies towards the more lucrative targeted therapies and immunotherapies class in the last decade. This class boasts several of the top-selling anticancer brands overall, and has fueled most of the recent rapid growth of the oncology market as a whole.
In Vitro Diagnostics (Immunochemistry and Infectious Immunology) Global Market Briefing to 2016
GlobalData
This report provides key data, information and analysis on the global immuno chemistry and infectious immunology markets. The report provides market landscape, competitive landscape and market trends information the immuno chemistry and infectious immunology markets. The report provides comprehensive information on the key trends affecting the market, and key analytical content on the market dynamics. The report also reviews the competitive landscape and technology offerings.
Monoclonal Antibodies: 2010
Datamonitor plc
Across the branded prescription pharmaceutical market monoclonal antibodies (MAbs) are forecast to be the strongest performing molecule type, delivering a forecast six year compound annual growth rate of 9.5% over 2009-15, outpacing the growth rates of small molecules, therapeutic proteins and vaccines.
Manufacturing of Biologics - Increasing Demand for Monoclonal Antibodies and Recombinant Proteins Drives Increases in Capacities and Innovative Production Technologies
GBI Research
GBI Research's report, “Manufacturing of Biologics - Increasing Demand for Monoclonal Antibodies and Recombinant Proteins Drives Increases in Capacities and Innovative Production Technologies”, provides the key data and analyzes the major challenges and drivers for the biomanufacturing industry. The report also analyzes the strengths, weaknesses of and opportunities for the stakeholders in the manufacturing of biologics.
Competitor Analysis Biosimilar and Biobetter/Biosuperior Antibodies
La Merie
The present Competitive Intelligence Report about Biosimilar and Biobetter/Biosuperior Antibodies provides a competitor evaluation in the field of recombinant monoclonal and polyclonal antibodies directed against CD20, Her2, VEGF, TNF, EGF-R, RSV and GPIIb/IIIa as of October 2010.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd
This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome
In this review, researchers from Harvard Medical School provide an update and overview of functional metabolomics that identified a new bioactive metabolome of docosahexaenoic acid.
Mucosis Announces Positive Proof-Of-Concept Data for Mimopath® Platform in Humans
Mimopath®-based vaccines are able to produce balanced immune responses in both circulating blood and the respiratory tract.
Revolutionary New Cancer Targeting Technology Described in Nature Medicine
Immunocore scientists manage to overcome cancer problem by boosting the ability of cancer-specific TCRs.
Immune Protection from an Unexpected Source
MIT biological engineers find that proteins in mucus help ward off viral infection.
The Immune Response to Melanoma is Limited by Thymic Selection of Self-Antigens
This study emphasizes the importance of investigating thymic expression of self-antigens prior to their inclusion in vaccination and immunotherapy strategies.
Possible Clues Found to why HIV Vaccine Showed Modest Protection
Analysis by NIH-supported scientists may help identify requirements for HIV vaccine.
Compound Halts Growth of Malaria Parasite
A drug candidate that has shown promise for neutralizing dangerous bacteria also prevents growth of the parasite that causes malaria.
Onyx Pharmaceuticals Announces Cell Publication Demonstrating Selectivity of Immunoproteasome Inhibitor ONX 0914
Article describes the crystal structures of two forms of the proteasome found in mammalian cells.
Ortho-Clinical Diagnostics, Inc. Announces Availability of HTLV-I/II Assay
Assay completes infectious disease menu, underscores OCD's commitment to the donor screening community.
Quantitative Proteomics Reveals that only a Subset of the Endoplasmic Reticulum Contributes to the Phagosome
Early proteomics studies indicated that the endoplasmic reticulum (ER) might contribute to phagosome genesis. This article provides compelling evidence of ER recruitment to phagosome by biochemical and morphological approaches.
In this review, researchers from Harvard Medical School provide an update and overview of functional metabolomics that identified a new bioactive metabolome of docosahexaenoic acid.
Mucosis Announces Positive Proof-Of-Concept Data for Mimopath® Platform in Humans
Mimopath®-based vaccines are able to produce balanced immune responses in both circulating blood and the respiratory tract.
Revolutionary New Cancer Targeting Technology Described in Nature Medicine
Immunocore scientists manage to overcome cancer problem by boosting the ability of cancer-specific TCRs.
Immune Protection from an Unexpected Source
MIT biological engineers find that proteins in mucus help ward off viral infection.
The Immune Response to Melanoma is Limited by Thymic Selection of Self-Antigens
This study emphasizes the importance of investigating thymic expression of self-antigens prior to their inclusion in vaccination and immunotherapy strategies.
Possible Clues Found to why HIV Vaccine Showed Modest Protection
Analysis by NIH-supported scientists may help identify requirements for HIV vaccine.
Compound Halts Growth of Malaria Parasite
A drug candidate that has shown promise for neutralizing dangerous bacteria also prevents growth of the parasite that causes malaria.
Onyx Pharmaceuticals Announces Cell Publication Demonstrating Selectivity of Immunoproteasome Inhibitor ONX 0914
Article describes the crystal structures of two forms of the proteasome found in mammalian cells.
Ortho-Clinical Diagnostics, Inc. Announces Availability of HTLV-I/II Assay
Assay completes infectious disease menu, underscores OCD's commitment to the donor screening community.
Quantitative Proteomics Reveals that only a Subset of the Endoplasmic Reticulum Contributes to the Phagosome
Early proteomics studies indicated that the endoplasmic reticulum (ER) might contribute to phagosome genesis. This article provides compelling evidence of ER recruitment to phagosome by biochemical and morphological approaches.
GenDx Obtains World Wide Distribution Rights of QIAGEN® LongRange PCR Kit
Performance of GenDx SBTexcellerator® reagents for tissue typing diagnostics in combination with LongRange PCR kit offers best HLA-typing results.
RCUK SSC Ltd Extends Contract with CRB
CRB to supply custom synthesized peptides and polyclonal and monoclonal antibodies for a further 12 months.
GE Healthcare Life Sciences Completes Acquisition of Xcellerex, Inc.
Acquisition expands GE Healthcare’s offering of technologies and services for the manufacture of recombinant proteins, antibodies and vaccines.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
SDIX Reports First Quarter 2012 Results
First advanced genomic antibody technology partnership with a major pharmaceutical company.
Compugen Reports First Quarter 2012 Financial Results
Non-cash Baize arrangements charges added significantly to loss for quarter.
Manhattan Pharmaceuticals, Inc. Announces Name Change
Company filed a Certificate of Amendment to its Certificate of Incorporation to change its name to TG Therapeutics, Inc. and also to implement a 1 for 56.25 reverse stock split.
China Biologic's Board Appoints Two New Independent Directors to Boost Corporate Governance
Company's Board of Directors appointed Mr. Zhijun Tong and Ms. Sandy (Han) Zhang as two new independent directors of the Company.
ARTES Announces a Strategic Collaboration Deal for Vaccine Development
ARTES is responsible for delivery of the production cell lines and processes to Crucell.
Rockland Immunochemicals and LDI Form Antibody Commercialization Partnership
Rockland will market LDI’s entire portfolio of LIMR monoclonal and polyclonal antibodies.
Performance of GenDx SBTexcellerator® reagents for tissue typing diagnostics in combination with LongRange PCR kit offers best HLA-typing results.
RCUK SSC Ltd Extends Contract with CRB
CRB to supply custom synthesized peptides and polyclonal and monoclonal antibodies for a further 12 months.
GE Healthcare Life Sciences Completes Acquisition of Xcellerex, Inc.
Acquisition expands GE Healthcare’s offering of technologies and services for the manufacture of recombinant proteins, antibodies and vaccines.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
SDIX Reports First Quarter 2012 Results
First advanced genomic antibody technology partnership with a major pharmaceutical company.
Compugen Reports First Quarter 2012 Financial Results
Non-cash Baize arrangements charges added significantly to loss for quarter.
Manhattan Pharmaceuticals, Inc. Announces Name Change
Company filed a Certificate of Amendment to its Certificate of Incorporation to change its name to TG Therapeutics, Inc. and also to implement a 1 for 56.25 reverse stock split.
China Biologic's Board Appoints Two New Independent Directors to Boost Corporate Governance
Company's Board of Directors appointed Mr. Zhijun Tong and Ms. Sandy (Han) Zhang as two new independent directors of the Company.
ARTES Announces a Strategic Collaboration Deal for Vaccine Development
ARTES is responsible for delivery of the production cell lines and processes to Crucell.
Rockland Immunochemicals and LDI Form Antibody Commercialization Partnership
Rockland will market LDI’s entire portfolio of LIMR monoclonal and polyclonal antibodies.
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Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments
Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.
Modular Bench Top Automation
BioTek Instruments
ELISA is one the most utilized assay formats in biomedical research. Numerous clinical, veterinary, and research assays use the specificity of antibodies to identify a diverse array of analytes from any number of different matrices. This poster details a modular bench top workstation capable of automating the assay process steps of most conventional ELISA assays.
Optical Microchip Sensors for Multiplexed Detection of Biological Pathogens
Stratophase
SpectroSens, a multi-channel optical microchip sensor system suitable for rapid, label-free multiplexed detection of a wide range of bio-hazardous agents is presented. Optical chips containing multiple high-precision planar Bragg gratings are exploited as low-cost, robust refractive index sensors.
A Mix-and-Read Cell-Based Assay for Antibody Screening Against Epidermal Growth Factor Receptor
TTP Labtech Ltd
The conventional antibody screening assay based on antibody-antigen binding has been enzyme-linked immunosorbent assay (ELISA). While tedious and consuming, ELISA has proved sufficient for the identification of antibodies directed against secreted antigens. However, cell surface antigens (e.g. GPCRs) provide challenges for ELISA due to the shortage of soluble antigens and high variability resulting from loss of cells during wash procedures.
Gene expression analysis of CD14+ monocytes immunomagnetically separated directly from whole blood: adaptation of protocols towards clinical trial requirements
1Miltenyi Biotec GmbH
Peripheral blood is widely used as starting material for biomarker discovery and validation using molecular biology technologies. The vast majority of currently published transcriptome data is based on RNA derived either from stabilized whole blood or peripheral blood mononuclear cells (PBMCs). Here, gene expression profiling studies and SOPs for fast, easy and specific manual or automated isolation of monocytes directly from whole blood are being described.
In silico screening of new potential TCR/CollagenII-MHCII inhibitors against rheumatoid arthritis
National Research Council (CNR) and Catholic University of Rome
Residues 261-273 of type II collagen bound to the MHC class II allele HLA-DR4 play a crucial role in rheumatoid arthritis. The protein–protein interactions between TCR and CII-MHCII complex may therefore serve as targets for the development of new drugs against RA. The aim of this study is to develop a pharmacophore virtual screening followed by molecular docking and dynamics calculations leading to the identification of new TCR/CII-MHCII inhibitors.
New Culture Medium Creates Immune Tolerance Between Two Allogeneic Tissue Cells
Biomedical Engineering Dept. and Dept. of Medicine &Epidemiology of Vet. Med. of UC Davis
We discovered that in vitro high dose of Progesterone (P) together with FGFa, EGF, VEGF, LPS had dual effect on Liver tissue cells: increased multiplication of Hepatocytes and suppressed all non-parenchymal (NP) liver tissue cells and created immune tolerance between two allogeneic mice Liver tissue
Investigating Viral dynamics
Imperial College London
Analysis of SIV next generation sequencing data for the estimation of escape rates in different animal groups and tissue compartments.
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments
Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.
Modular Bench Top Automation
BioTek Instruments
ELISA is one the most utilized assay formats in biomedical research. Numerous clinical, veterinary, and research assays use the specificity of antibodies to identify a diverse array of analytes from any number of different matrices. This poster details a modular bench top workstation capable of automating the assay process steps of most conventional ELISA assays.
Optical Microchip Sensors for Multiplexed Detection of Biological Pathogens
Stratophase
SpectroSens, a multi-channel optical microchip sensor system suitable for rapid, label-free multiplexed detection of a wide range of bio-hazardous agents is presented. Optical chips containing multiple high-precision planar Bragg gratings are exploited as low-cost, robust refractive index sensors.
A Mix-and-Read Cell-Based Assay for Antibody Screening Against Epidermal Growth Factor Receptor
TTP Labtech Ltd
The conventional antibody screening assay based on antibody-antigen binding has been enzyme-linked immunosorbent assay (ELISA). While tedious and consuming, ELISA has proved sufficient for the identification of antibodies directed against secreted antigens. However, cell surface antigens (e.g. GPCRs) provide challenges for ELISA due to the shortage of soluble antigens and high variability resulting from loss of cells during wash procedures.
Gene expression analysis of CD14+ monocytes immunomagnetically separated directly from whole blood: adaptation of protocols towards clinical trial requirements
1Miltenyi Biotec GmbH
Peripheral blood is widely used as starting material for biomarker discovery and validation using molecular biology technologies. The vast majority of currently published transcriptome data is based on RNA derived either from stabilized whole blood or peripheral blood mononuclear cells (PBMCs). Here, gene expression profiling studies and SOPs for fast, easy and specific manual or automated isolation of monocytes directly from whole blood are being described.
In silico screening of new potential TCR/CollagenII-MHCII inhibitors against rheumatoid arthritis
National Research Council (CNR) and Catholic University of Rome
Residues 261-273 of type II collagen bound to the MHC class II allele HLA-DR4 play a crucial role in rheumatoid arthritis. The protein–protein interactions between TCR and CII-MHCII complex may therefore serve as targets for the development of new drugs against RA. The aim of this study is to develop a pharmacophore virtual screening followed by molecular docking and dynamics calculations leading to the identification of new TCR/CII-MHCII inhibitors.
New Culture Medium Creates Immune Tolerance Between Two Allogeneic Tissue Cells
Biomedical Engineering Dept. and Dept. of Medicine &Epidemiology of Vet. Med. of UC Davis
We discovered that in vitro high dose of Progesterone (P) together with FGFa, EGF, VEGF, LPS had dual effect on Liver tissue cells: increased multiplication of Hepatocytes and suppressed all non-parenchymal (NP) liver tissue cells and created immune tolerance between two allogeneic mice Liver tissue
Investigating Viral dynamics
Imperial College London
Analysis of SIV next generation sequencing data for the estimation of escape rates in different animal groups and tissue compartments.
Applications of rapid immunoassays (FAST ILA) in cell culture/fermentation and process development using the Threshold System
Molecular Devices
Accurate measurement of the concentration of a biological product is important in bioreactor/fermenter monitoring, downstream processing and final product quality control. Currently, electrophoretic, chromatographic and immunochemical methods are the most commonly used. These three methods are currently used in combination to provide the desired sample information.
Optimizing the Labeling of Proteins
Molecular Devices
The Threshold® Immuno-Ligand Assay (ILA) adapts reagents used in ELISA, RIA or radioreceptor assays for the Threshold System by covalently attaching biotin or fluorescein labels to the binding proteins and/or ligands. To simplify labeling and purification of proteins, Molecular Devices has formulated biotin and fluorescein as N-hydroxysuccinimide esters.
The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
BMG LABTECH
ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
BMG Labtech
During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.
Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay
Thermo Fisher Scientific
Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Thermo Fisher Scientific
LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Antimicrobial Properties of Thermo Scientific Finnpipette F1 Compared to Traditional Pipettes
Thermo Fisher Scientific
In this application note the antimicrobial properties of the Thermo Scientific Finnpipette F1 were compared to traditional pipettes without antimicrobial treatment. The experiments were performed by an independent laboratory (Institut für Biotechnische Forschung und Entwicklung Graf GmbH, Kirkel-Limbach, Germany).
Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Thermo Fisher Scientific
During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.
Molecular Devices
Accurate measurement of the concentration of a biological product is important in bioreactor/fermenter monitoring, downstream processing and final product quality control. Currently, electrophoretic, chromatographic and immunochemical methods are the most commonly used. These three methods are currently used in combination to provide the desired sample information.
Optimizing the Labeling of Proteins
Molecular Devices
The Threshold® Immuno-Ligand Assay (ILA) adapts reagents used in ELISA, RIA or radioreceptor assays for the Threshold System by covalently attaching biotin or fluorescein labels to the binding proteins and/or ligands. To simplify labeling and purification of proteins, Molecular Devices has formulated biotin and fluorescein as N-hydroxysuccinimide esters.
The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
BMG LABTECH
ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
BMG Labtech
During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.
Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay
Thermo Fisher Scientific
Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Thermo Fisher Scientific
LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Antimicrobial Properties of Thermo Scientific Finnpipette F1 Compared to Traditional Pipettes
Thermo Fisher Scientific
In this application note the antimicrobial properties of the Thermo Scientific Finnpipette F1 were compared to traditional pipettes without antimicrobial treatment. The experiments were performed by an independent laboratory (Institut für Biotechnische Forschung und Entwicklung Graf GmbH, Kirkel-Limbach, Germany).
Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Thermo Fisher Scientific
During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.
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