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The Fight Against Food Fraud: The Analyt...
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Featured Products
Featured Product - IncuCyte® Live-Cell Imaging and Analysis System from Essen BioScience
IncuCyte® Live-Cell Imaging and Analysis System from Essen BioScience
Featured Product - NovoCyte™
NovoCyte™

Webcasts
Webcast - Driving Innovation in Antibody Discovery and Development Through Novel Partnership ModelsDriving Innovation in Antibody Discovery and Development Through Novel Partnership Models
In this webinar, Dr Robert Williams, Chief Development Scientist, Cancer Research UK, will discuss how partnership between academia and industry can accelerate drug development.
Advanced Molecular Tools for Proteome Analyses
Masood Kamali-Moghaddam, Uppsala University, speaking at Advances ibn qPCR and dPCR 2014

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Single Cell Omics 2011
Select Biosciences Ltd

The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Cancer Targeted Therapies and Immunotherapies Market Forecast
Datamonitor plc

The oncology market has witnessed a sizeable shift of focus away from cytotoxic therapies and antihormonal therapies towards the more lucrative targeted therapies and immunotherapies class in the last decade. This class boasts several of the top-selling anticancer brands overall, and has fueled most of the recent rapid growth of the oncology market as a whole.
Monoclonal Antibodies: 2010
Datamonitor plc

Across the branded prescription pharmaceutical market monoclonal antibodies (MAbs) are forecast to be the strongest performing molecule type, delivering a forecast six year compound annual growth rate of 9.5% over 2009-15, outpacing the growth rates of small molecules, therapeutic proteins and vaccines.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Scientific News
Featured Article
Shedding Light on HIV Vaccine Design
Broadly speaking - Mathematical modelling of host-pathogen coevolution sheds light on HIV vaccine design.

Progress In Vaccination Against Vespid Venom
Researchers at the Helmholtz Zentrum München and the Technical University Munich have presented a method which facilitates a personalised procedure for wasp allergy sufferers.
New Drug Target for Inflammatory Disorders
Penn study finds enigmatic molecules maintain equilibrium between fighting infection and inflammatory havoc.
Oxygen Can Impair Cancer Immunotherapy
Researchers have identified a mechanism within the lungs where anticancer immune resposnse is inhibited.
LncRNAs Maintain Immune Health
Long non-coding RNAs are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders.
Researchers Identify Influenza Fighting Molecule
St. Jude scientists have identified the molecule that recognizes influenza virus cells and triggers their death to fight the infection.
Breast Milk Sugar May Protect Babies Against Deadly Infection
Researchers from Imperial College London find that a sugar found in some women’s breast milk may protect babies against Group B streptococcus.
New Method of Cancer Immunotherapy
Stanford chemists have dicovered a new form of cancer immunotherapy using sugar presence manipulation.
Immune Breakthrough: Unscratching Poison Ivy’s Rash
Researchers from Monash University have discovered the molecular cause of poison ivy rash.
Alien-Like Reproduction of Single-Celled Fungi
Biologists have directly observed how microspridia, a single-celled fungi, replicate and spread.
Business News
Denali, F-star in $1Bn CNS Collaboration
F-star and Denali will R&D antibodies for delivery across the blood-brain barrier into the CNS.
Vedanta Granted U.S. Patent
Vedanta Biosciences granted U.S. patent that covers pharmaceutical compositions for microbiome therapeutics based on bacterial consortia.
SAB, BARDA Contract for MERS Treatment
SAB Biotherapeutics announces $5.3M contract from BARDA for therapeutic manufacturing and testing from rapid response platform.
Biological Supplier Boosted by UW Expertise
A supplier that produces custom-made protein and antibodies has taken advantage of UW manufacturing expertise.
Vedanta, NYU Development Collaboration
Vedanta Biosciences announces collaboration with the NYU Langone Medical Center to develop microbiome-derived immunotherapies for cancer.
Genmab, Gilead Announce Agreement
Collaboration aims to use the DuoBody® technology platform to create and develop bispecific antibody candidates for a therapeutic program targeting HIV.
Eleven Biotherapeutics Signs $270M Deal with Roche
Eleven Biotherapeutics announces licensing deal with Roche for EBI-031 that could total $270Million.
Protagen, Inova Announce Agreement for BICD2 Biomarker
The license agreement will allow Inova to add the novel biomarker to their portfolio of CTD reagents to help improve diagnosis of this debilitating disease.
Illumina, FlowJo Partner
Companies to develop software for analysis and reporting of single cell data will advance research into cell function, disease progression, and therapeutic response.
BMS Announces Fails Phase 3 Trial
Opdivo did not meet trial primary endpoint of progression-free survival in patients expressing PD-L1 = 5%.

Events
2nd Glycobiology World Congres
29 Aug 2016
2nd Glycobiology World Congres ...
International Conference on Al
07 Sep 2016
International Conference on Al ...
World Anti-Microbial Resistanc
08 Sep 2016
World Anti-Microbial Resistanc ...
Pregnancy and Childbirth: Acad
13 Sep 2016
Pregnancy and Childbirth: Acad ...

ePosters
Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice
1. School of Pharmacy and Pharmaceutical Sciences, 2. School of Psychology Cardiff University, Cardiff, UK

The work presented in this poster aims to assess whether intracerebroventricular (ICV) administration of 2B3 alleviated age dependent memory deficits in PDAPP mice and to determine whether 2B3 altered APP metabolism and NMDA receptor phosphorylation ex vivo.
Quantitative Cell-Based Bioassays for Individual and Combination Immune Checkpoint Immunotherapy Targets
Promega Corporation

Immune checkpoint receptors are promising new immunotherapy
targets for the treatment of a variety of diseases including cancer and
autoimmune-mediated disorders. We developed a suite of cell-based
bioluminescent reporter bioassays for individual and combination
immune checkpoint immunotherapy targets including: PD-1 (PD-L1 or PD-L2), CTLA-4, LAG-3, TIGIT, PD-1+TIGIT, GITR, 4-1BB, CD40, and OX40.

Mobility of Aeroallergens in Home: Effect of Location of Air Sampling and Implication for Evaluation of Patient Exposure
1Inspirotec Inc, Chicago, IL, Kenilworth Medical Allergy & Immunology, Kenilworth, IL

The Inspirotec sampler permitted the easy testing of multiple locations within a household. Air sampling simultaneously at 12 locations by other technologies would have been technically challenging. These were run by an untrained operator.
A Simple Plate Based Assay Using pH Sensor Dye to Screen for Internalizing Antibody
Promega Corporation

Receptor mediated internalization is a key mechanism of action (MOA) for antibody drug conjugates (ADCs). However, current methods of studying antibody internalization have several limitations including: 1) A multistep process not suitable for screening; 2) Low signal-to-background ratios; 3) Not suitable for kinetic measurements. We have developed a method that mitigates problems associated with traditional internalization assays.
Better Cell-Based Assays for Anti-CTLA-4, Anti-PD-1/PD-L1, and Bispecific Immunotherapy Drug Studies
Promega Corporation

Here we report the development of a panel of robust reporter assays to measure the potencies for biologics in immunotherapy. These assays reflect mode of action and can serve as valuable tools in immunotherapy drug development and discovery.
Development of a Robust Reporter-based T cell Activation Assay for Therapeutic Biologics in Immunotherapy
Promega Corporation

Jurkat T-cells stably expressing luciferase reporter driven by IL2 promoter or NFAT-RE, are used as effector cells. Tumor cell lines endogenously expressing cancer antigen are used as antigen presenting cells (APC). By co-cultivating the two cell lines in the presence of CD3 bispecific antibody, TCR/CD3 is activated in Jurkat effector cells. Luciferase activity is up regulated through IL-2 promoter or NFAT-RE activation.
Reporter Bioassays to Assess Therapeutic Antibodies for Immunotherapy Programs
Promega Corporation

Immunotherapy, also called biologic therapy or biotherapy, stimulates certain parts of the immune system to fight diseases such as cancer. Important drug targets in immunotherapy include: Co-inhibitory receptors, such as PD-1/PD-L1, CTLA-4, LAG3, Tim3; and co-stimulatory receptors, such as GITR, CD40, OX40, 4-1BB.
Current approaches to assaying these targets are cumbersome and variable. Here we offer an improved in vitro bioassay approach.
Modelling CLL cell and T-cell Migration in a Dynamic Circulating Model of CLL
'Cardiff CLL Research Group, Institute of Cancer & Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK. 2CRUK Institute for Cancer Studies, University of Birmingham, Vincent Driv

We have recently developed a novel circulating model of chronic lymphocytic leukaemia (CLL) that mimics the transient interactions that take place between circulating lymphocytes and vascular endothelium. Here we show that both normal and malignant lymphocytes actively underwent transendothelial migration.
Quantification of Natural Killer Cell-Mediated Cytotixicity using Celigo Imaging Cytometry
Nexcelom Bioscience LLC, The University of Texas MD Anderson Cancer Center

Time-course tracking of % lysis eliminates multiple controls & the effect of non-uniform cell seeding in the final cytotoxicity calculation. The # of cells used is less than the cells needed for Release assays & Flow Cytometry. Flow cytometry & Release assays require a seeding density of 100K target cells increasing the number of effector cells to the millions. The visual observation of ADCC or CDC on the images can be convincing to conclude the functionality of antibodies or complements.
Novel culture medium using a small-molecule agonist of thrombopoetin receptor
1ReproCELL, Inc. & 2Nissan Chemical Industries

ReproHSC medium for the culture of hematopoietic stem cells. facilitates the culture and expansion of CD34+/CD38- cells that retain their HSC properties
Application Notes
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
ENRICHMENT AND PURIFICATION OF CD3+ T-CELLS FROM HUMAN UMBILICAL CORD BLOOD
Quad Technologies

Quad Technologies’ has partnered with the University of Massachusetts Medical School (Worcester, MA, USA) to evaluate the performance of the MagCloudz™ Streptavidin cell separation kit.
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Malvern Instruments Limited

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
Engineering Monoclonal Antibodies to Enhance Drugability: A Case Study
Malvern Instruments Limited

In this manuscript we compare the stability of three different engineered antibodies as determined by SEC-HPLC analysis during accelerated stability studies, with the stability predicted by DSC.
Characterization of IgG Monomers & Their Aggregates
Malvern Instruments Limited

In this application note we characterize two antibody samples using column calibration and multi-detection SEC.
Understanding Antibody and Viral Glycoprotein Interactions Using CG-MALS
Wyatt Technology Corporation

We used size-exclusion chromatography coupled with multi-angle light scattering to determine the molar mass and native oligo-meric state of a viral glycoprotein.
Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Wyatt Technology Corporation

Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Tag-lite® two-cell assay: a valuable tool for protein drug discovery
Tecan Group Ltd.

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.
Transcreener® ADP2 TR-FRET Red Assay
Tecan Group Ltd.

Adenosine diphosphate (ADP) is an important mediator of cellular metabolism that is essential for maintaining energy levels. The Transcreener ADP2 TR-FRET Red Assay is intended for the detection of ADP production by any kinase or ATPase, and has been developed specifically for high throughput screening applications.
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