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Featured Products
Featured Product - Miriad RVF Antibody Detection Kit
Miriad RVF Antibody Detection Kit
Featured Product - IMMULITE 2000 XPi Immunoassay System
IMMULITE 2000 XPi Immunoassay System

Webcasts
Webcast - Accelerate Your Research With Tecan´s New Multimode Microplate Reader Platform!Accelerate Your Research With Tecan´s New Multimode Microplate Reader Platform!
In this webinar, solutions will be presented for fast DNA quantification, single cell counting and viability analysis, and automating long-term live kinetic cell assays.
Advanced Molecular Tools for Proteome Analyses
Masood Kamali-Moghaddam, Uppsala University, speaking at Advances ibn qPCR and dPCR 2014

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Chromatography Resin Market by Application, Techniques & Type - Trends & Forecast to 2018
MarketsandMarkets

The chromatography resin market is expected to grow at a decent pace during the coming decade driven by its increasing application in monoclonal antibody production and food analytics.
Cell Analysis Market by Instruments, Consumables & Application - Global Forecast to 2018
MarketsandMarkets

The global cell analysis market is a technology-driven market and is marked by the ?Threat of Obsolescence,? wherein technologies as well as their adoption by end users changes very rapidly. Hospitals, academic and government institutes, as well as pharmaceutical and biotechnology companies are increasing their focus on using cell analysis as a powerful research tool in research, drug discovery, and diagnosis.
Security Technologies in Biotechnology
RI Technologies

The report serves as a guide to security technology industry for biotechnology applications, covering more than 350 companies that are engaged in security technology/products and services.
Blood - Components, Testing & Collection
RI Technologies

This market insight report gives an insight into global blood ? components, testing and collection market. The report also provides market analytics by Product Type.
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
Life Science Consumables 2013: Markets and Opportunities
Biopharm Reports

Techniques such as PCR, DNA microarray, DNA sequencing, mass spectrometry and flow cytometry have grown significantly in the last decade and by 2015 markets for these five areas are expected to exceed $50 billion, globally. In these and related fields, consumables are generally the second or third largest area in cost terms, after instrumentation.
Scientific News
Adults Only Really Catch Flu About Twice a Decade, Suggests Study
Researchers developed a mathematical model of how our immunity to flu changes over a lifetime as we encounter different strains of the virus.
NIH Announces $41.5 Million in Funding for the Human Placenta Project
Better understanding of the placenta promises to improve the health of mothers and children.
Scientists Uncover New Role for Neurotransmitter that Helps Fight Infection
Scientists have shed new light on the complexities of the immune system that could help develop vaccines to boost natural defences against disease.
NIH-funded Scientists Create Potential Long-acting HIV Therapeutic
New molecule also might prevent HIV infection.
Epigenetic Study Highlights Drug Targets for Allergies and Asthma
Scientists have discovered over 30 new genes that predispose people to allergies and asthma, some of which could be targets for new drugs.
Epigenomics of Alzheimer’s Disease Progression
Study of epigenomic modifications reveals immune basis of Alzheimer's disease.
Link Between Powerful Gene Regulatory Elements and Autoimmune Diseases Revealed
Findings point to potential drug targets.
NIH-Sponsored HIV Vaccine Trial Launches In South Africa
Early-stage trial aims to build on RV144 results.
Researchers Find New Mechanism That Controls Immune Responses
The findings appear online in the journal Science.
The Company You Keep
La Jolla Institute scientists reveal dual role for key T cell factor.
Business News
Baxter's Bioscience Business Acquires SuppreMol
Acquisition includes SuppreMol's early-stage pipeline of protein therapeutics for autoimmune and allergic diseases.
MRC Technology Launches Respiratory ‘Call for Targets’
Project focused on potential small molecule or antibody targets in pathways important in the development or progression of respiratory disease.
TxCell to Present at ROTH Capital Partners Investor Conference in US
TxCell invited to speak at largest US meeting for investors in emerging growth companies.
Bristol-Myers Squibb to Expand its Immuno-Oncology Pipeline
Gains full rights to Flexus’ lead preclinical IDO1 inhibitor F001287 and the company’s broad IDO/TDO discovery program.
Cell Medica Announces Start of Commercial Cell Therapy Manufacture
Manufacturing will be focused on Cytovir™ CMV for the treatment of patients with CMV infections.
Boehringer Ingelheim Selects Genedata Biologics as Antibody Discovery Workflow Platform
Genedata Biologics integrates and streamlines workflows for protein therapeutics R&D groups across multiple Boehringer Ingelheim sites.
Merck Millipore Announces Agreement with Precision Biologics
Merck Millipore services include design and development of cost-effective process to deliver high yield and productivity.
MRC Technology Appoints General Counsel and Company Secretary
Dr Edward Bliss will join MRCT on 16 March.
TxCell €1.7M for Crohn’s Disease Study
Top line results of this study are expected at the end of 2016 / early 2017.
Wyss Institute Videos Now on LabTube
The Wyss Institute for Biologically Inspired Engineering has created a channel on Labtube.

Events
Pittcon 2015
08 Mar 2015
Pittcon 2015 ...
Biodetection & Biosensors
17 Mar 2015
Biodetection & Biosensors ...
Neuroscience Virtual Conferenc
18 Mar 2015
Neuroscience Virtual Conferenc ...
4th Inflammatory and Immunolog
18 Mar 2015
4th Inflammatory and Immunolog ...

ePosters
Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM


Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge Theatre
Marked increase in basophil activation during non-anaphylactic allergic reactions to peanut in man
Imperial College London

Our data imply an important role for basophils in the evolution of acute IgE-mediated reactions to food allergens.
Ten-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis
Allergy and Asthma Specialists

Efficacy of sublingual immunotherapy for Juniper induced allergic rhinitis is presented.
Association between asthma-related emergency department visits, meteorological measurements, and air quality concentrations in the Bronx (2001-2008)
1. Herricks High School, New Hyde Park, NY 2. Albert Einstein College of Medicine, Bronx, NY 3. SUNY Downstate, Brooklyn, NY

Evaluate the association between asthma-related emergency department visits (AREDV), meteorological measurements, and air quality concentrations in a high asthma prevalence area, the New York City borough of the Bronx.
Ocular papillary changes on the caruncle surface in allergic conjunctivitis
1Private Practice, Azusa, CA 2The May Eye Care Center and Associates, Hanover, PA. 3Rutgers University, New Brunswick, NJ.

The caruncle is small, pink, globular nodule at the inner corner of the eye. We found the papillary changes of the caruncle corresponds to changes in palpebral conjunctiva seen in allergic conjunctivitis. There may indicate a greater inflammatory response in the caruncle resulting in greater itching in the nasal corners of the eye. Allergists can easily assess the caruncle.
Increasing the Generalization Capability of Biomarkers Through Systems Biology Malaria Vaccines Case Study
1. Anaxomics Biotech, Barcelona, Spain 2. Malaria Immunology Group, CRESIB, Barcelona, Spain

The results underline the utility of Systems Biology (and specially Anaxomics’s TPMS) for the interpretation of high-throughput data in BM identification, with a better generalization capability than conventional methods.
Apoplastic Venom Allergen‐like Proteins of Cyst Nematodes Modulate the Activation of Basal Plant Innate Immunity by Cell Surface Receptors
aLaboratory of Nematology Wageningen University, 6708 PB, Wageningen, The Netherlands; bCentre for BioSystems Genomics, 6700 AB, Wageningen, The Netherlands

We conclude that parasitic nematodes most likely utilize VAPs to suppress the activation of defenses by immunogenic breakdown products in damaged host tissue.
Non-disruptively Count and Quantify Fluorescent iPS Colonies During Secondary Reprogramming: 7 min per 6-well Plate, Dual-fluorescence Whole Well Imaging Cytometry
Nexcelom Bioscience; University of Edinburgh

Nexcelom’s Celigo imaging cytometer has been applied to provide automated, rapid assessment of iPS reprogramming.

Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method
Nexcelom Bioscience, LLC

This study demonstrates that the cell culture assay for tumorsphere size was successfully adapted to 384-well plate for a 3D spheroid assay using U-bottom low attachment 384-well and the Celigo Automated Imager for image acquisition and analysis. Moreover, the utilization of an imager provided insight on sphere and cell fate after long term drug treatment.
HOMOGENEOUS ADCs BEARING TWO DIFFERENT PAYLOADS SHOW STRONG SYNERGY IN TUMOR KILLING
Dophen Biomed and TUBE Pharmaceuticals GmbH

We presented a one-pot reaction to prepare site-specific ADCs using available mABs on hand without re-engineering. We have identified a novel non-cleavable linker, which increases not only ADC stability, but also potency. We also demonstrate synergy in cancer cell killing of hybrid ADC loaded with two different toxins
Application Notes
Characterization of IgG Monomers & Their Aggregates
Malvern Instruments Limited

In this application note we characterize two antibody samples using column calibration and multi-detection SEC.
Understanding Antibody and Viral Glycoprotein Interactions Using CG-MALS
Wyatt Technology Corporation

We used size-exclusion chromatography coupled with multi-angle light scattering to determine the molar mass and native oligo-meric state of a viral glycoprotein.
Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Wyatt Technology Corporation

Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Tag-lite® two-cell assay: a valuable tool for protein drug discovery
Tecan Group Ltd.

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.
Transcreener® ADP2 TR-FRET Red Assay
Tecan Group Ltd.

Adenosine diphosphate (ADP) is an important mediator of cellular metabolism that is essential for maintaining energy levels. The Transcreener ADP2 TR-FRET Red Assay is intended for the detection of ADP production by any kinase or ATPase, and has been developed specifically for high throughput screening applications.
Efficient washing of magnetic beads
Tecan Group Ltd.

The use of magnetic beads as the solid phase in a multiplexed ELISA enables high throughput cytokine screening and offers several advantages over common ELISA assays with direct coupling of the analyte to the well-surface.
Automating ELISAs on Tecan’s Freedom EVO® using Optimiser™ technology from Siloam Biosciences
Tecan Group Ltd.

One of the challenges in life sciences research today is to discover methods for running key assays more quickly, more reliably and using lower volumes of reagents and sample, but still with improved sensitivity. One area where this particularly holds true is for traditional enzyme-linked immunosorbent assays (ELISAs), whose application provides a useful measurement of antigens, including cytokines and a host of other biomarkers.
Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.
A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.
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