Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scripps Led Team Awarded $22.5 Million for Immune Response Project

Published: Thursday, August 30, 2012
Last Updated: Thursday, August 30, 2012
Bookmark and Share
The team have received a five-year project renewal from the NIH to uncover the workings of the immune system.

The grant is focused on innovative technologies that will ultimately provide data for improving a wide range of human diseases that include viral and bacterial infections and inherited immune disorders.

"I’m delighted the National Institute of Allergy and Infectious Diseases has decided to continue supporting this important research," said the grant’s principal investigator Richard Ulevitch, who is a professor and chairman emeritus at Scripps Research. “Since the initiative began 10 years ago, the consortium has made seminal contributions to the field. Now, thanks to the new funding, there are more discoveries to come.”

The project takes an unusual wide-angle “genetic and systems biology” approach to learning how we stay healthy in the face of numerous microbes in our environment. In contrast to traditional hypothesis-driven research, in which a single gene or protein is selected for study based on its proposed function, team members assemble information about multiple genes, proteins, and biochemical pathways without preconceived ideas about function. This data is then integrated and examined from multiple perspectives to understand the immune response as a whole.

In addition to Ulevitch and his group at Scripps Research, the consortium includes the laboratories of Alan Aderem of the Seattle Biomedical Research Institute, Bruce Beutler of University of Texas Southwestern Medical Center, Christopher Goodnow of the Australian National University, and Garry Nolan of Stanford University.

Ulevitch notes that the group is now especially interested in the intersection between innate and adaptive immunity. Innate immunity, our body's first line of defense, can destroy foreign invaders and trigger inflammation that contributes to their demise. If microorganisms make it past this gauntlet, the body calls on adaptive immunity. Here, T cells, B cells, antibodies, and killer cells come into play; the adaptive immune system also stores "memories" of the offending microorganisms to be on the alert for future attacks.

The team is using a genetic approach in mice, known as “forward genetics,” to develop a detailed model of innate and adaptive immune responses to infection. “It is now crystal clear that data from mouse genetics provides insights into human disease,” Ulevitch said. “When we started there were a lot more unknowns, but now there is a long list of genes identified in the mouse that cause both specific mouse phenotypes and are similarly linked to human disease.”

The group provides resources to the scientific community at large, including a Web-based data portal to access the team’s findings (see www.systemsimmunology.org).

This program has received ongoing support from NIH since 2002. The NIH project number for the grant is U19 AI100627.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

HIV Structure Stabilized
Findings represent ‘big accomplishment’ in biomedical engineering and design.
Wednesday, June 29, 2016
Secrets of a Deadly Virus Family Revealed
Scripps Research scientists uncover the glycoprotein structure of LCMV. The findings could guide development of treatments for Lassa fever.
Wednesday, April 27, 2016
First ‘Teenage’ HIV-Neutralizing Antibody Discovered
Scientists have studied the evolution of anti-HIV antibodies, with hopes of creating a vaccine to prevent AIDS.
Wednesday, April 06, 2016
Encouraging Foundation for Upcoming AIDS Vaccine Clinical Trial
Engineered vaccine protein binds key immune cells that exist in nearly everyone.
Tuesday, March 29, 2016
Novel Role of Mitochondria in Immune Function Identified
Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
Monday, September 21, 2015
Team Led by TSRI Scientists Shows AIDS Vaccine Candidate Successfully ‘Primes’ Immune System
New research shows that an experimental vaccine candidate can stimulate immune activity necessary to prevent HIV infection.
Thursday, June 25, 2015
Revealing Molecular Secrets Behind the Health Benefits of Wine
Resveratrol has been much in the news as the component of grapes and red wine associated with reducing “bad cholesterol,” heart disease and some types of cancer.
Wednesday, April 30, 2014
Scripps Researchers Find New Point of Attack on HIV for Vaccine Development
The newly identified site can be attacked by human antibodies in a way that neutralizes the infectivity of a wide variety of HIV strains.
Friday, April 25, 2014
Scripps Research Appoints Cancer Biologist
Christoph Rader is appointed as associate professor in the Department of Cancer Biology and the Department of Molecular Therapeutics.
Monday, August 06, 2012
Scientific News
Breakthrough Flu Vaccine Inhibited by Pre-existing Antibodies
Universal truths – how existing antibodies are sabotaging the most promising new human flu vaccines.
Zika Vaccine Candidates Show Promise
Two experimental vaccines have shown promise against a major viral strain responsible for the Brazilian Zika outbreak.
Antibody Drug Shows Promise in HIV Treatment
Researchers are a step closer to an alternative HIV treatment that has the potential for lasting effects and less frequent dosing.
Targeting Autoimmunity
Researchers have developed a strategy to treat a rare autoimmune disease which could lead to treatments of other autoimmune diseases.
Flu Vaccine May Reduce Death Risk of Type 2 Diabetes
New research suggests that a new flu vaccine may reduce probability of type 2 diabetes patients being hospitalised with stroke and heart failure.
Gut Bacteria Older than Human Species
Some bacteria have lived in the human gut since before we were human, suggesting evolution could have a larger role inhuman bacterial makeup.
Evidence of Mosquito Transmitting Zika
A direct link between the Yellow fever mosquito and Zika transmission has been found following investigation into selective mosquito control.
Antibody-Based Drug for Multiple Sclerosis
New antibody-based drug paves the way for new strategies for controlling and treating multiple sclerosis.
Three-Drug Combinations Counter Antibiotic Resistance
Research shows that combinations of three different antibiotics can treat resistant bacteria, even if they are ineffective independently.
Mapping Zika’s Routes to Developing Fetus
UC researchers show how Zika virus travels from a pregnant woman to her fetus, and also identified a drug that could stop it.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!