Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Antibody Found in Lupus May Protect Against Certain Cancers

Published: Friday, October 26, 2012
Last Updated: Friday, October 26, 2012
Bookmark and Share
Yale Cancer Center researchers report that an antibody associated with the autoimmune disease systemic lupus erythematosus may actually offer a treatment for certain cancers.

In autoimmune diseases such as lupus, the immune system attacks and damages the body’s own cells and tissue, rather than destroying foreign invaders.

Antibodies targeting the host's DNA are found in lupus, and many of these antibodies are toxic. Some of these lupus antibodies penetrate living cells and nuclei.

One unusual cell-penetrating lupus autoantibody that is not harmful to normal cells or tissues was previously isolated from a mouse model of lupus by Richard H. Weisbart, M.D. of UCLA.

The antibody, known as 3E10, is not only benign but has the capacity to penetrate both healthy and malignant cells and cell nuclei.

Knowing that capacity, Yale researchers were investigating whether 3E10 could be used as a drug-delivery vehicle.

But they discovered to their surprise that the antibody already had the ability to sensitize cancer cells to radiation and chemotherapy and interfere with their ability to sustain themselves through DNA repair.

With the discovery of this cancer cell susceptibility, the researchers further found that 3E10, when used alone, could selectively kill cancer cells with DNA repair deficiencies such as those with mutations in the BRCA2 gene.

BRCA2 is a tumor suppressor that, when damaged or deficient, can lead to malignancies such as breast, ovarian, pancreatic, and prostate cancers.

“Finding this characteristic of 3E10 opens up a new avenue for researching treatment of BRCA2-related cancers,” said lead author Peter M. Glazer, M.D., professor and chairman of therapeutic radiology, professor of genetics, and a member of Yale Cancer Center. “It may also lead us to new therapies for other types of cancers such as brain gliomas.”

This discovery may also lead to important new insights into lupus itself.

"The most immediate relevance of our findings to human disease is the new recognition that lupus antibodies might be able to be harnessed as new therapies for cancer," said author James E. Hansen, M.D. assistant professor of therapeutic radiology and a member of Yale Cancer Center.

Hansen continued, "It also opens up new windows for exploration into the biology of lupus antibodies and may explain the unexpectedly low rates of breast, ovarian, and prostate cancer in lupus patients. It also may help explain why lupus patients appear to be very sensitive to DNA-damaging agents."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Creating More Potent Vaccines
Yale researchers uncovered a new role for a type of immune cell, known as regulatory T cells, in promoting long-term immunity.
Wednesday, July 08, 2015
Researchers Solve Multiple Sclerosis Puzzle
Yale study shows the role that T cells play in MS.
Monday, May 18, 2015
New Tool To Explore Mysteries Of The Immune System
Yale scientists use CyTOF to study a range of conditions.
Monday, April 20, 2015
Cold Virus Replicates Better At Cooler Temperatures
Study shows that the immune response to rhinovirus is influenced by temperature.
Tuesday, January 06, 2015
New Class of Synthetic Molecules Mimics Antibodies
A Yale University lab has crafted the first synthetic molecules that have both the targeting and response functions of antibodies.
Wednesday, December 24, 2014
Protein Predicts Response To New Immunotherapy Drug
Trial shows that response to treatment may be predicted by the presence of an immune-suppressing protein in non-cancerous immune cells.
Friday, November 28, 2014
Immune System Surprise Hints at New Strategy for Fighting HIV
Surprising twist may open a new avenue in the fight.
Tuesday, November 18, 2014
Immune Cells get Cancer-Fighting Boost From Nanomaterials
Yale researchers used bundled carbon nanotubes to incubate cytotoxic T cells.
Monday, August 18, 2014
Commonly Used Drugs May Not Be Effective Against Autoimmune Illness
The study appears in the Cell Press journal Immunity.
Tuesday, March 18, 2014
Yale Team Implants Human Innate Immune Cells in Mice
Groundbreaking study has reproduced human immune function at a level not seen previously.
Tuesday, March 18, 2014
Lung Disease and Melanoma: a Common Molecular Mechanism?
Researchers have solved a biological mystery about the common genesis of many serious diseases such as asthma and metastatic melanoma.
Monday, September 02, 2013
Drug Preserves Beta Cells in New Cases of Type 1 Diabetes
A drug in clinical trials has been shown to preserve insulin-producing pancreatic beta cells in nearly half of subjects newly diagnosed with type 1 diabetes.
Tuesday, August 06, 2013
Nature’s Own Nanoparticles Harnessed to Target Disease
Using a novel form of immune-genetic therapy, researchers have successfully inhibited a strong immune allergic inflammatory response in the skin of mice.
Friday, July 12, 2013
Promising Drug Prevents Cancer Cells from Shutting Down Immune System
An investigational drug that targets the immune system’s ability to fight cancer is showing promising results in Yale Cancer Center (YCC) patients.
Monday, June 10, 2013
Combined Immunotherapy Shows Promising Results Against Advanced Melanoma
Combining two cancer immunotherapy drugs in patients with advanced melanoma produced rates of tumor regression that appeared greater than in prior trials with either drug alone.
Monday, June 10, 2013
Scientific News
Antibody Treatment Efficacious in Psoriasis
An experimental, biologic treatment, brodalumab, achieved 100 percent reduction in psoriasis symptoms in twice as many patients as a second, commonly used treatment, according to the results of a multicenter clinical trial led by Mount Sinai researchers.
Four Gut Bacteria Decrease Asthma Risk in Infants
New research by scientists at UBC and BC Children’s Hospital finds that infants can be protected from getting asthma if they acquire four types of gut bacteria by three months of age.
Escape Prevention
Studying flu virus structure brings us a step closer to a permanent vaccine.
New Molecular Marker for Killer Cells
Cell marker enables prognosis about the course of infections.
Editing Genes to Create HIV Killers
Seattle scientists have managed to genetically transform human cells in the lab from HIV targets to HIV killers, and the technique could have implications for cancer and other diseases.
Antibiotic Overuse Might be Why so Many People Have Allergies
The Centers for Disease Control and Prevention estimates that drug resistant bacteria cause 23,000 deaths and two million illnesses each year.
Molecular ‘Kiss Of Death’ Flags Pathogens For Destruction
Researchers have discovered that our bodies mark pathogen-containing vacuoles for destruction by using a molecule called ubiquitin, commonly known as the "kiss of death."
Opening the Door to Safer, More Precise Cancer Therapies
New method regulates when, and how strongly, cancer-killing therapeutic T cells are activated.
Vaccination On The Horizon For Severe Viral Infection Of The Brain
Researchers from the University of Zurich and the University Hospital Zurich reveal possible new treatment methods for a rare, usually fatal brain disease.
What Do Animal Viruses Have to Do with Human Health?
Simon Anthony studies animal infections to prevent outbreaks in people.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos