Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Can Cancer Be Turned Against Itself?

Published: Thursday, February 07, 2013
Last Updated: Thursday, February 07, 2013
Bookmark and Share
Immune system can use melanoma's own proteins to kill off cancer cells, TAU researchers find.

Though a small group of proteins, the family called Ras controls a large number of cellular functions, including cell growth, differentiation, and survival. And because the protein has a hand in cellular division, mutated Ras, which can be detected in one-third of all tumors, contributes to many human cancers by allowing for the rapid growth of diseased cells.

Now Prof. Yoel Kloog of Tel Aviv University's Department of Neurobiology, along with Dr. Itamar Goldstein of TAU's Sackler Faculty of Medicine and the Sheba Medical Center and their students Helly Vernitsky and Dr. Oded Rechavi, has found that oncogenic Ras, which promotes cancer development, can also alert the immune system to the presence of cancer cells.

For the first time, the researchers have shown the transfer of oncogenic Ras in human cells from melanoma cells to T cells, which belong to a group of white blood cells that are part of the immune system. This transfer allows the immune cells to gather crucial intelligence on what they are fighting and develop the necessary cytokines, or signalling molecules, to kill the melanoma cells.

Prof. Kloog suggests that a drug that enhances the transfer of the oncogene from the tumor to the immune cells is a potential therapy to augment the anti-cancer immune response. This research has been published in the Journal of Immunology.

Finding the tipping point

Although they found that immune cells often exchange proteins among themselves, the discovery that melanoma cells transfer mutated Ras is an intriguing first. And it's this initial transfer that begins what the researchers call a positive feedback loop.

In the lab, researchers incubated T-cells from patients with human melanoma cells that had originated from tumors to track the process of handing-off various proteins. They uncovered a circuit that runs between the cancer and immune cells. Once the melanoma cells pass oncogenic Ras to the T-cells, the T-cells are activated and begin to produce cytokines, which enhances their capacity to kill cancer cells.

As these melanoma cells pass along the mutated Ras, the immune cells become increasingly active. Eventually, enough oncogenic material is transferred across the immune cells' threshold, causing the T-cells to act on the melanoma cells from which the oncogenic Ras was derived. Ultimately, this transfer tips the scales in favor of the immune cells, the researchers say.

Exploiting the information transfer

The next step is to develop a therapy that can enhance the transfer in patients with cancers linked to oncogenic Ras, says Prof. Kloog. And although their research has so far focused on melanoma, which is known to elicit the response of the immune system, he believes that this finding could be applicable to other types of cancers.

There is a constant balancing act between cancer cells and the immune system, says Dr. Goldstein. Under normal circumstances, the immune system will kill some cancerous cells on a daily basis. The disease becomes critical when the immune system can no longer keep cancer cells in check. Although there are many theories as to how cancer cells break free of this cycle, scientists are still attempting to discover why this occurs.

Prof. Kloog and Dr. Goldstein hope that this research leads to a better understanding of how the immune system fights tumors. "It's a part of the interaction between cancer and the immune system that is not well known," says Dr. Goldstein. "We are trying to gather more comprehensive data on all the proteins that are being passed around, and how this information impacts the immune system's response to cancer."

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,200+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Reversing Antibiotic Resistance in Bacteria
Scientists at Tel Aviv University say they have developed a tool that tackles the problem of antibiotic resistance while also providing a new approach to combating bacterial infections.
Tuesday, June 09, 2015
Breathe Easier: Get Your D
TAU study finds asthmatics with Vitamin D deficiency are 25 percent more likely to experience acute attacks.
Tuesday, October 28, 2014
Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Preventing "Friendly Fire" in the Pancreas
Researchers inhibit process that leads to the body attacking its own insulin-producing cells.
Smartphone Laboratory Detects Cancer
Researchers develop low-cost, portable laboratory on a smartphonecapable of analysing multiple samples simultaneously.
Overlooked Molecules Could Revolutionise our Understanding of the Immune System
Researchers have discovered that around one third of all the epitopes displayed for scanning by the immune system are a type known as ‘spliced’ epitopes.
NIH Study Determines Key Differences between Allergic and Non-Allergic Dust Mite Proteins
Researchers at NIH have uncovered factors that lead to the development of dust mite allergy and assist in the design of better allergy therapies.
New Antibody Therapy Permanently Blocks SIV Infection
An international research team has developed an effective treatment strategy against the HIV-like Simian Immunodeficiency Virus (SIV) in rhesus macaques.
Contribution Increases by Tenfold The Mouse Mutation Resources of One Type Available
The repository provides academic researchers with unique genetic models that are unavailable commercially.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
DNA Vaccines Protect Monkeys Against Zika Virus
Two experimental Zika virus DNA vaccines developed by NIH scientists protected monkeys against Zika infection.
Rare Flu-Thwarting Mutation Discovered
Study finds protein mutation, that is encoded by influenza, causes the virus to lose any defence against the immune system.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos