Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Fast Acting Arthritogenic Monoclonal Antibody Cocktails

Published: Friday, March 01, 2013
Last Updated: Thursday, February 28, 2013
Bookmark and Share
New 5-Clone CIAA kit for the induction of Collagen-Induced Arthritis.

AMSBIO has announced a new 5-Clone Collagen Antibody-Induced Arthritis (CIAA) kit for the induction of Collagen-Induced Arthritis (CIA) in various species.

Collagen Antibody-Induced Arthritis (CAIA) has been widely used since 1998 when 4-clone cocktail (Arthrogen-CIA® arthritogenic monoclonal antibodies) kits first appeared.

In order to induce consistent arthritis more effectively in various mouse strains including CAIA low responder C57BL/6 mice, and a variety of unpredictable knockout and transgenic mice with C57BL/6 (H-2b) or 129/Sv (H-2b) backgrounds, a new 5-clone cocktail kits have been developed by adding a new clone to the 4-clone cocktail.

The new 5-Clone CIAA produces faster results: Typically severe arthritis is induced within 24-48 hours instead of the four weeks required to induce CIA after immunization with type II collagen.

Unlike the original CIA model, which requires a restricted MHC haplotype, the new 5-Clone CAIA model is broadly applicable and can induce arthritis in almost all strains of mice, including CIA-resistant, T-cell deficient, gene knockout, and transgenic mice.

Beneficially the new 5-Clone kits offer excellent consistency meaning the severity of arthritis induced now directly correlates to the dose of monoclonal antibody cocktail, and more severe and consistent arthritis can be induced by increasing the dose of monoclonal antibody cocktail.

Therefore, this model is ideal for studying the pathological role of individual gene products, cytokines, as well as screening and evaluating anti-inflammatory agents without influences of complete or incomplete Freund's adjuvant, which strongly affects the host's immune system.

AMSBIO also offer a wide range of various species and types of highly purified cartilage collagen, type II, IX, and XI collagen together with different Freund’s Adjuvants to study Collagen Induced Arthritis.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Shedding Light on HIV Vaccine Design
Broadly speaking - Mathematical modelling of host-pathogen coevolution sheds light on HIV vaccine design.
Oxygen Can Impair Cancer Immunotherapy in Mice
Researchers at NIH have discovered that the T cells contain a group of oxygen-sensing proteins which act to limit inflammation within the lungs.
Progress In Vaccination Against Vespid Venom
Researchers at the Helmholtz Zentrum München and the Technical University Munich have presented a method which facilitates a personalised procedure for wasp allergy sufferers.
New Drug Target for Inflammatory Disorders
Penn study finds enigmatic molecules maintain equilibrium between fighting infection and inflammatory havoc.
New Method of Cancer Immunotherapy
Stanford chemists have dicovered a new form of cancer immunotherapy using sugar presence manipulation.
Immune Breakthrough: Unscratching Poison Ivy’s Rash
Researchers from Monash University have discovered the molecular cause of poison ivy rash.
Alien-Like Reproduction of Single-Celled Fungi
Biologists have directly observed how microspridia, a single-celled fungi, replicate and spread.
Improved Immunity in Older Age
A study from Oxford and Basel universities may point the way to maintaining our immune systems as we get older.
Russian TB Thrives Within Macrophages
MIPT researchers have identified features of mycobacterium tuberculosis strains that may explain their success.
New Inflammatory Disease Discovered
NIH researchers have discovered a rare and potentially deadly disease - otulipenia - the mostly affects children.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!