Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Tetragenetics Announces Collaboration with Amgen

Published: Wednesday, April 03, 2013
Last Updated: Wednesday, April 03, 2013
Bookmark and Share
Exclusive research license of Tetragenetics’ technology for surface antigen drug target.

Tetragenetics Inc. a 2012 Gates Foundation Phase ll grant recipient and an emerging biotechnology company engaged in the development of particle-based vaccines and expression of membrane proteins for drug discovery, reported today that it has entered into a technology access and exclusive research license agreement with Amgen for a defined, but undisclosed, surface antigen.

Dr. Ted Clark, Founder and Chief Scientific Officer of Tetragenetics, said, “Tetragenetics has created a unique capability for making antigens which enable the discovery and production of novel antibodies that target validated but previously difficult to produce membrane protein drug targets.”

“One of the central problems that industry faces with an immunopharmacological approach to these intractable targets is presentation of the right extracellular domains. Tetragenetics’ discovery technology has distinct and quantifiable advantages over mammalian cells which, up until now, have been the principal cell lines available for discovery purposes,” continued Dr. Clark. “Our agreement with Amgen marks the second major partnership for Tetragenetics and the first for this specific family of targets.”

“Our collaboration with Amgen validates Tetragenetics’ proprietary drug discovery platform,” noted John Reilly, V.P. Business Development. “We will be announcing further collaborations with leading biotech and pharmaceutical companies as we expand our partnering programs.”

Tetragenetics’ technology enables high density heterologous expression of recombinant human membrane proteins on the cell surface of Tetrahymena thermophila. Immunogen preparations of the drug targets can be made in any of several formats: cell ghosts (“pellicles”), membrane vesicles, lipid rafts, or partially purified soluble protein. These enriched preparations are designed to enhance antibody production against the extracellular portions of the target.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Developing a More Precise Seasonal Flu Vaccine
During the 2014-15 flu season, the poor match between the virus used to make the world’s vaccine stocks and the circulating seasonal virus yielded a vaccine that was less than 20 percent effective.
Fighting Cancer with Borrowed Immunity
A new step in cancer immunotherapy: researchers from the Netherlands Cancer Institute and University of Oslo/Oslo University Hospital show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might.
Loss Of Y Chromosome Increases Risk Of Alzheimer’s
Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease. This is in addition to an increased risk of death from other causes, including many cancers. These new findings by researchers at Uppsala University could lead to a simple test to identify those at risk of developing Alzheimer’s disease.
Immune Cells Remember Their First Meal
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response – a discovery that may pave the way for new treatments for many human diseases.
"Sunscreen" Gene May Guard Against Melanoma
USC-led study reveals that melanoma patients with deficient or mutant copies of the gene are less protected from harmful ultraviolet rays.
Myeloid-Derived Suppressor Cells Play Role in Tumor Growth
Researchers at Baylor College of Medicine have reported a new mechanism that helps cancer cells engage myeloid-derived suppressor cells.
Drug Might Help Treat Sepsis
A DNA enzyme called Top1 plays a key role in turning on genes that cause inflammation in mouse and human cells in response to pathogens. A drug blocking this enzyme rescued mice from lethal inflammatory responses, suggesting a potential treatment for sepsis.
Large-scale HIV Vaccine Trial to Launch in South Africa
NIH-funded study will test safety, efficacy of vaccine regimen.
Immune System Implicated in Gastroschisis
UCSF researchers show that the immune system is implicated in gastroschisis. The findings could lead to improved treatments for the belly birth defect.
Hay Fever's Hidden Supporting Substances
TUM study finds that non-allergenic substances in pollen heighten the immune response.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!