Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Immune Response Linked to Key Enzyme

Published: Friday, April 12, 2013
Last Updated: Friday, April 12, 2013
Bookmark and Share
A family of enzymes may contribute to scientists’ understanding of signaling molecules involved in the body’s immune response.

The family of enzymes, called Sir2, has been extensively studied for their role in aging.

The research, published April 4 in the journal Nature, was led by senior author Hening Lin, associate professor of chemistry and chemical biology. Lin and colleagues reported that the enzyme Sirtuin-6 (SIRT6) promotes the secretion of a signaling molecule called tumor necrosis factor-alpha (TNF), which is important for triggering immune responses in mammalian cells.

Rheumatoid arthritis, for example, is associated with is an overabundance of TNF. The molecule also promotes cancer cell death. The study found that SIRT6 promotes TNF secretion by removing long-chain fatty acyl groups from protein lysine residues.

It was not previously known that SIRT6 could play this key chemical role in the TNF promotion process. Based on the findings, researchers may one day look to manipulate SIRT6 in therapies to treat diseases.

This is the first study to explain how such long-chain fatty acyl groups are removed in mammalian cells.

“This long-chain fatty acyl lysine modification was reported 30 years ago, but no one knew its physiological function, so our finding helps explain that,” Lin said.

The study was funded in part by the National Institutes of Health. Co-authors include researchers from the University of Hong Kong, Rockefeller University and Harvard Medical School. The study’s lead authors were Hong Jiang, research associate, Saba Khan, graduate student, both in Lin’s lab, and Yi Wang, a researcher at the University of Hong Kong.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Key to Chronic Fatigue Syndrome is in Your Gut, Not Head
Researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.
Wednesday, June 29, 2016
Synthetic Immune Organ Produces Antibodies
Cornell engineers have created a functional, synthetic immune organ that produces antibodies and can be controlled in the lab, completely separate from a living organism.
Friday, June 12, 2015
Expelled DNA that Traps Toxins May Backfire in Obese
The body’s most powerful immune cells may have a radical way of catching their prey that could backfire on people who are overweight.
Wednesday, June 19, 2013
TB Bacteria's Trash-Eating Inspires Search for New Drugs
When hijacking a garbage truck, one might as well make use of the trash. That logic drives how tuberculosis-causing bacteria feed, say Cornell scientists.
Tuesday, June 11, 2013
Discovery Could Revolutionize Immunization
Immune cells in newborns appear to be more ready to do battle than previously thought.
Monday, April 29, 2013
Inflammation Drives Crohn's Disease, Says Study
Recent studies show marked changes in the composition of the intestinal bacteria in people with CD.
Tuesday, August 21, 2012
Bacteria Employ 'Quality-control' Machinery, say Biomolecular Engineers
Like quality-control managers in factories, bacteria possess built-in machinery that track the shape and quality of proteins trying to pass through their cytoplasmic membranes.
Friday, August 03, 2012
The Force is with us: GEDI Chip Sorts Prostate Cancer Cells
Geometrically Enhanced Differential Immunocapture chip identify and collect cancer cells from a patient's bloodstream.
Friday, June 29, 2012
Immune Cells Found to Counter Obesity-Related Diabetes
Activation of NKT cells reduces inflammation, and also reduces insulin resistance and increases glucose tolerance.
Monday, May 21, 2012
Scientific News
Shedding Light on HIV Vaccine Design
Broadly speaking - Mathematical modelling of host-pathogen coevolution sheds light on HIV vaccine design.
Progress In Vaccination Against Vespid Venom
Researchers at the Helmholtz Zentrum München and the Technical University Munich have presented a method which facilitates a personalised procedure for wasp allergy sufferers.
New Drug Target for Inflammatory Disorders
Penn study finds enigmatic molecules maintain equilibrium between fighting infection and inflammatory havoc.
Oxygen Can Impair Cancer Immunotherapy
Researchers have identified a mechanism within the lungs where anticancer immune resposnse is inhibited.
LncRNAs Maintain Immune Health
Long non-coding RNAs are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders.
Researchers Identify Influenza Fighting Molecule
St. Jude scientists have identified the molecule that recognizes influenza virus cells and triggers their death to fight the infection.
Breast Milk Sugar May Protect Babies Against Deadly Infection
Researchers from Imperial College London find that a sugar found in some women’s breast milk may protect babies against Group B streptococcus.
New Method of Cancer Immunotherapy
Stanford chemists have dicovered a new form of cancer immunotherapy using sugar presence manipulation.
Immune Breakthrough: Unscratching Poison Ivy’s Rash
Researchers from Monash University have discovered the molecular cause of poison ivy rash.
Alien-Like Reproduction of Single-Celled Fungi
Biologists have directly observed how microspridia, a single-celled fungi, replicate and spread.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!