Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

ModiQuest Announces Publication of Novel Antibodies

Published: Tuesday, April 23, 2013
Last Updated: Tuesday, April 23, 2013
Bookmark and Share
ModiQuest BV announced the publication of novel anti-citrullinated therapeutic antibodies for the treatment of rheumatoid arthritis.

In this publication, ModiQuest describes the discovery of novel therapeutic anti-citrullinated protein antibodies (tACPAs) that prevent the onset and/or exacerbation of inflammation and that prevent or strongly reduce the occurrence of swelling and joint damage, using a collagen antibody-induced arthritis mouse model. The ACPAs discovered by ModiQuest are directed against a citrullinated epitope in histone-2A protein in man and mouse.
 
ModiQuest has made this discovery using its proprietary antibody discovery technology platforms M-Fuse™ (highly efficient hybridoma electrofusion technology), M-Select™ (B-cell selection technology for low immunogenic or multiple antigen targets) and M-Phage™ (proprietary phase display libraries). All three technology platforms are also used by ModiQuest’s service business, ModiQuest Research BV, for custom antibody lead generation in third party service projects.
 
“The novel tACPA leads we have discovered offer a new way to contribute to the treatment of rheumatoid arthritis, and we are today in discussions with a number of pharmaceutical companies to progress the tACPA leads into clinical development”, says Dr. Jos Raats, CEO of ModiQuest. “The discovery of these antibody leads again demonstrates the huge potential of our M-Fuse™, M-Select™ and M-Phage™ technologies for the discovery of novel therapeutic and diagnostic antibodies against low-immunogenic targets.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Food Triggers Creation of Regulatory T Cells
IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Switch Lets Salmonella Fight, Evade Immune System
Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.
Tricked-Out Immune Cells Could Attack Cancer
New cell-engineering technique may lead to precision immunotherapies.
Neural Networks Adapt to the Presence of a Toxic HIV Protein
HIV-associated neurocognitive disorders (HAND) afflict approximately half of HIV infected patients.
HIV Protein Manipulates Hundreds of Human Genes
Findings search for new or improved treatments for patients with AIDS.
Breaking the Brain’s Garbage Disposal
The children’s ataxia gene problem turned out to be not such a big deal genetically — it was such a slight mutation that it barely changed the way the cells made the protein.
Flesh-Eating Bacteria Work Together
Scientists recently discovered different strains of deadly flesh-eating bacteria working together to spread infection and they now have a better understanding of the role of the toxins they produce. The discovery could change how the illness and other diseases are treated.
Utilizing Antibodies from Ebola Survivors
A collaborative team from The University of Texas Medical Branch at Galveston, Vanderbilt University, The Scripps Research Institute and Integral Molecular Inc. have learned that antibodies in the blood of people who have survived a strain of the Ebola virus can kill various types of Ebola.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!