Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

CLSI Releases Newborn Screening Document

Published: Wednesday, May 22, 2013
Last Updated: Wednesday, May 22, 2013
Bookmark and Share
NBS06 - A newborn blood spot screening for severe combined immunodeficiency.

Clinical and Laboratory Standards Institute (CLSI) has released NBS06-A-Newborn Blood Spot Screening for Severe Combined Immunodeficiency by Measurement of T-cell Receptor Excision Circles; Approved Guideline.

Severe combined immunodeficiency (SCID) is a lethal disorder not evident at birth. This document addresses its detection by population-based newborn screening (NBS), which uses dried blood spot (DBS) specimens to measure T-cell receptor excision circles (TREC).

TREC may be used to reveal the presence of SCID, and this presymptomatic detection is required for effective treatment.

This guideline, which is intended for use by NBS clinicians, laboratory personnel, producers of laboratory products related to NBS, and those involved with the oversight of NBS programs, facilitates the incorporation of SCID NBS into the routine operation of existing NBS programs.

Methodologically, it focuses on measuring TREC in DBS specimens by real-time quantitative polymerase chain reaction, the method currently in use by all NBS laboratories.

Both startup and operating NBS programs benefit from the use of NBS06, which contains detailed protocols for screening and follow-up.

"There is the potential for a cure with early detection of SCID," said Harry Hannon, PhD, and Roshini Sarah Abraham, PhD, D(ABMLI); Chairholder and Vice-Chairholder of the NBS06-A document development committee. "Newborn screening can save lives from this devastating disorder."

NBS06 conveys detailed information for laboratory practice, including calibration, quality control, and proficiency testing. It also addresses program issues such as short-term follow-up (ie, notification and tracking to establish or rule out a diagnosis).

The guideline includes clinical and immunological background on SCID and other immunodeficiency disorders that may present with low or no TREC content in newborns.

This guideline also boasts several appendixes that showcase information vital to the document, including the first comprehensive tabulation of primary and secondary conditions detected by the TREC assay, and an exemplar generic flow chart for TREC assays in NBS.

SCID NBS is technologically evolving with respect to both laboratory practices and outcome measures. NBS06 provides the foundation for refinements in the future.

The participation and close collaboration of all NBS programs is critical to the success of this endeavor.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Gut Bacteria Older than Human Species
Some bacteria have lived in the human gut since before we were human, suggesting evolution could have a larger role inhuman bacterial makeup.
Evidence of Mosquito Transmitting Zika
A direct link between the Yellow fever mosquito and Zika transmission has been found following investigation into selective mosquito control.
Antibody-Based Drug for Multiple Sclerosis
New antibody-based drug paves the way for new strategies for controlling and treating multiple sclerosis.
Three-Drug Combinations Counter Antibiotic Resistance
Research shows that combinations of three different antibiotics can treat resistant bacteria, even if they are ineffective independently.
Mapping Zika’s Routes to Developing Fetus
UC researchers show how Zika virus travels from a pregnant woman to her fetus, and also identified a drug that could stop it.
Treating HIV with Cancer-Fighting Gene Shows Promise
A type of gene immunotherapy that has shown promising results against cancer could also be used against HIV.
Protein Teams Activate T-Cells
Caltech researchers have discovered T-cell genetic switching is controlled by four proteins acting in a multi-tiered fashion.
'Antigen-Presenting Cell' Defends Against Cancer
Through advanced imaging, researchers have identified cells that encourages increases in immune system cancer defences.
Zika Epidemic Likely to End Within Three Years
A team of scientists has predicted that the current Zika epidemic is likely to end within three years because there will be too few people left to infect.
Go-Between Immune Cell is Key to Priming the Body’s Fight Against Cancer
‘Antigen-presenting cell’ activates T cells by alerting them to the presence of tumors.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!