Life Technologies will provide the company's proprietary technology, Dynabeads® CD3/CD28 CTS™, which possess unique biological properties suited to production of active, therapeutically relevant immune system cells.
The agreement includes rights to use Life Technologies' intellectual property to perform the resulting therapy, and is exclusive for use in the field of chimeric antigen receptors for the treatment of cancer.
"The collaboration with Novartis highlights the distinct capabilities that Life Technologies can provide in the therapeutic realm," said Greg Lucier, chairman and chief executive officer of Life Technologies. "Taken with our previous announcements of companion diagnostic collaborations, the current agreement demonstrates how Life is uniquely positioned to facilitate drug development through alliances with pharma."
Chimeric antigen receptor T cell based immunotherapy constitutes a novel, individualized method of combating cancers. Novartis is working to commercialize technology developed at the University of Pennsylvania that has demonstrated startling efficacy in research studies. In two 2011 publications1,2, University of Pennsylvania researchers described application of immunotherapy in three patients, all of whom experienced durable complete or partial remission of their cancers within three to four weeks of treatment. A 2013 publication in the New England Journal of Medicinedescribed complete responses with one ongoing in two children with leukemia3.
The personalized therapy consists of removing blood cells from cancer patients; isolating and activating T cells; genetically modifying the T cells thereby programming those cells to recognize and attack cancer cells; expanding the T cells; and, lastly, introducing those cells back into the body so the patient's immune system can take over. Under the terms of the current agreement, Life Technologies' Dynabeads® CD3/CD28 CTS™, will be used to isolate, activate and expand the T cells.
"Dynabeads ® CD3/CD28 CTS™ have unique properties that are ideal for producing a robust immunotherapeutic," said Oystein Aamellem, head of Cellular Medicine at Life Technologies. "Not only do the beads assure that T cells are separated from any unwanted cells, it also triggers the T cells to reproduce in a natural and controlled manner, ensuring a therapeutically relevant population is transferred back into the patient."
"The current agreement with Novartis represents a significant step in the growth of Life Technologies from a research tools provider to a leading medical device company," said Lucier. "We're very excited about the opportunity to work with Novartis to deliver novel therapeutics to fill a critical need in cancer care."
1. Chimeric Antigen Receptor—Modified T Cells in Chronic Lymphoid Leukemia. Porter, David L., et. al.; N Engl J Med 2011; 365:725-733.
2. T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia. Kalos, Michael, et. al.; Sci Transl Med 10 August 2011: Vol. 3, Issue 95, p. 95.
3. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. Grupp, Stephan A., et al.; N Engl J Med 2013; 368;1509-1518.