Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Phosphorylation: One of the Hottest Topics in Cell Biology Research

Published: Tuesday, November 26, 2013
Last Updated: Tuesday, November 26, 2013
Bookmark and Share
Over 140 phosphospecific antibodies are developed in AbboMax, Inc.

Phosphorylation plays critical roles in the regulation of many cellular processes. It is tightly associated with protein activity and is a key point of protein function regulation.

Phosphorylation is the attachment of a phosphate group to a protein or other organic molecule.

Once the new phosphate group is added by protein phosphorylation, it changes the structure of its host protein. The new phosphorus group alters the role of the protein: it can activate, deactivate, or cause a change in function. It turns many protein enzymes on and off.

Reversible phosphorylation of proteins is an important regulatory mechanism that occurs in both prokaryotic and eukaryotic organisms.

Protein phosphorylation is a post-translational modification of proteins in which a serine, a threonine, and/or tyrosine residue are phosphorylated by a protein kinase.

Sometimes a cell uses a phosphorylation cascade, to produce an outcome. Upon the deactivating signal, the protein becomes dephosphorylated again and stops working. A phosphatase is an enzyme that removes a phosphate group from the protein.

AbboMax, Inc. has developed over 140 phosphospecific antibodies. The unique Universal phosphotyrosine antibody is among them.

Another group, anti-AMP-activated protein kinase (AMPK) antibodies are highly conserved from yeast to plants and animals and play a key role in the regulation of energy balance at both the cellular and the whole body levels.

Once activated, it affects a metabolic switch from an anabolic to a catabolic state, both by acutely phosphorylating metabolic enzymes and, in the longer term, by regulating gene expression. AbboMax offers a group of anti-estrogen receptor (ER) antibodies. ER is a member of the steroid receptor superfamily.

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,100+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Overlooked Molecules Could Revolutionise our Understanding of the Immune System
Researchers have discovered that around one third of all the epitopes displayed for scanning by the immune system are a type known as ‘spliced’ epitopes.
NIH Study Determines Key Differences between Allergic and Non-Allergic Dust Mite Proteins
Researchers at NIH have uncovered factors that lead to the development of dust mite allergy and assist in the design of better allergy therapies.
New Antibody Therapy Permanently Blocks SIV Infection
An international research team has developed an effective treatment strategy against the HIV-like Simian Immunodeficiency Virus (SIV) in rhesus macaques.
Contribution Increases by Tenfold The Mouse Mutation Resources of One Type Available
The repository provides academic researchers with unique genetic models that are unavailable commercially.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
DNA Vaccines Protect Monkeys Against Zika Virus
Two experimental Zika virus DNA vaccines developed by NIH scientists protected monkeys against Zika infection.
Rare Flu-Thwarting Mutation Discovered
Study finds protein mutation, that is encoded by influenza, causes the virus to lose any defence against the immune system.
Mapping the Human Immune System
Researchers try to harness supercomputers to create the first map of the human immune system.
Antibody Drug Conjugates May Help Personalize Radiotherapy
Biomarker-driven study shows promise in sensitizing HER2 positive tumors to radiation and chemotherapy.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,100+ scientific videos